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Using Clinical and Echocardiographic Characteristics to Characterize the Risk of Ischemic Stroke in Patients with COVID-19
Coronavirus disease 2019 (Covid-19) caused by infection with SARS-CoV-2 has been associated with a variety of systemic complications resulting in substantial morbidity and mortality.1 Early case series identified an elevated incidence of ischemic stroke in patients with COVID-19.2-4 In retrospective studies, ischemic stroke has been identified in 0.5-5.8% of patients hospitalized with COVID-19.5-10 Infection with COVID-19 has been independently associated with acute ischemic stroke compared with control subjects and the severity of COVID-19 syndrome correlates with risk acute stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 7, 2021 Category: Neurology Authors: Connor Oates, Solomon W. Bienstock, Michael Miller, Gennaro Giustino, Tatyana Danilov, Nina Kukar, Nikola Kocovic, Dylan Sperling, Ranbir Singh, Daniel Benhuri, Frans Beerkens, Anton Camaj, Stamatios Lerakis, Lori Croft, Laura K. Stein, Martin E. Goldman Source Type: research

Original Article: Increased Stroke Severity and Mortality in Patients with SARS-CoV-2 Infection: An Analysis from the N3C Database
Studies from early in the COVID-19 pandemic showed that patients with ischemic stroke and concurrent SARS-CoV-2 infection had increased stroke severity. We aimed to test the hypothesis that this association persisted throughout the first year of the pandemic and that a similar increase in stroke severity was present in patients with hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2023 Category: Neurology Authors: Jackson A Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan D Assefa, Arti Patel, Johanna J Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B Worrall, Donald E Brown, Karen C Johnston, Andrew M Southerland, N3C consortium Source Type: research

Increased stroke severity and mortality in patients with SARS-CoV-2 infection: An analysis from the N3C database
Studies from early in the COVID-19 pandemic showed that patients with ischemic stroke and concurrent SARS-CoV-2 infection had increased stroke severity. We aimed to test the hypothesis that this association persisted throughout the first year of the pandemic and that a similar increase in stroke severity was present in patients with hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2023 Category: Neurology Authors: Jackson A Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan D Assefa, Arti Patel, Johanna J Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B Worrall, Donald E Brown, Karen C Johnston, Andrew M Southerland, N3C consortium Source Type: research

Characteristics of a Diverse Cohort of Stroke Patients with SARS-CoV-2 and Outcome by Sex
Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), usually presents as a respiratory illness. Neurological manifestations can be seen in 36.4% of patients.1 Patients with vascular risk factors (VRFs), including history of stroke, tend to have worse prognosis.2 COVID-19 triggers a robust inflammatory response which leads to hypercoagulability and thromboembolism.3 Reports of stroke in patients with COVID-19 are mostly limited to small case series or case reports of ischemic stroke (IS), though intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) have also been reported.
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2020 Category: Neurology Authors: G. Trifan, F.D. Goldenberg, F.C. Caprio, J. Biller, M. Schneck, A. Khaja, T. Terna, J. Brorson, C. Lazaridis, Z. Bulwa, R. Alvarado-Dyer, F.G. Saleh-Velez, S. Prabhakaran, E.M. Liotta, A. Batra, N.J. Reish, S. Ruland, M. Teitcher, W. Taylor, P. De la Pena Source Type: research

Stroke and Thromboprophylaxis in the era of COVID-19
In the rapidly evolving COVID-19 pandemic, many patients presenting with acute ischemic stroke may be potentially infected with the Severe Acute Respiratory Syndrome Coronavirus (SARS CoV-2) agent. As stroke patients are often unable to give an adequate history of preceding COVID-19 symptoms, all stroke patients in areas with high prevalence of community transmission should be considered potential cases. Observational studies have suggested an increased tendency for thrombotic events in patients infected with SARS CoV-2.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2020 Category: Neurology Authors: Alice Ma, Carlos S. Kase, Ashkan Shoamanesh, Mohamad Abdalkader, Aleksandra Pikula, Anvitha Sathya, Luciana Catanese, Alun T. Ellis, Thanh N. Nguyen Source Type: research

Cerebral Herniation Secondary to Stroke-associated Hemorrhagic Transformation, Fulminant Cerebral Edema in Setting of COVID-19 Associated ARDS and Active Malignancy
We present the case of a very rapid neurologic and radiographic decline of a patient with an acute ischemic stroke who developed rapid fulminant cerebral edema leading to herniation in the setting of hypercarbic respiratory failure attributed to SARS-CoV-2 infection.
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2020 Category: Neurology Authors: Katarina Dakay, Gurmeen Kaur, Stephan A. Mayer, Justin Santarelli, Chirag Gandhi, Fawaz Al-Mufti Tags: Case Report Source Type: research

DO ELEVATED LEVELS OF INFLAMMATORY BIOMARKERS PREDICT THE RISK OF OCCURRENCE OF ISCHEMIC STROKE IN SARS-CoV2 ?: AN OBSERVATIONAL STUDY
: Stroke, a dreaded complication of SARS-CoV2, has been reported in 0.9 to 5% of SARS-CoV2 patients. There are concerns that SARS-CoV2 infection has a significant independent association with acute ischemic stroke, even in the absence of conventional cerebrovascular risk factors. Whether elevated levels of inflammatory biomarkers have predictive value in the occurrence of stroke in SARS-CoV2 is poorly understood.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2021 Category: Neurology Authors: Dr. Nitisha Goyal, Dr. Ajoy K Sodani, Dr. Rahul Jain, Dr. Heera Ram Source Type: research

Stroke priorities during COVID-19 outbreak: acting both fast and safe
While the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spreads all over the world, the healthcare systems are facing the dramatic challenge of simultaneously fight against the outbreak and life-threating emergencies.In this biological setting, emergency departments and neurovascular teams are exposed to high risk of infection and should therefore be prepared to deal with neurological emergencies safely.The purpose of this article is to analyze the current evidence on COVID-19 in the context of acute ischemic stroke and to describe the model of behavior we are putting into action to maintain the stroke pathw...
Source: Journal of Stroke and Cerebrovascular Diseases - May 4, 2020 Category: Neurology Authors: Alessandro Pedicelli, Iacopo Valente, Fabio Pilato, Marisa Distefano, Cesare Colosimo Source Type: research

Acute Stroke as the Presenting Symptom of SARS-CoV-2 Infection in a Young Patient with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Coronavirus disease of 2019 (COVID-19) has currently reached pandemic levels and neurological manifestations, including stroke as the initial presentation, have been increasingly recognized (1-3). Majority of the reported ischemic strokes are large vessel occlusion or embolic appearing strokes and are frequently described in critically ill patients with severe COVID-19 disease (2), but small ischemic strokes have also been reported (4). Recently, stroke as the presenting symptom in younger patients (
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2020 Category: Neurology Authors: Gabriela Trifan, Maureen Hillmann, Fernando D. Testai Source Type: research

Bilateral large vessel occlusion causing massive ischemic stroke in a covid-19 patient
The case of a 70-year-old male presenting an ischemic stroke related to COVID-19 infection is described. He was initially admitted to the hospital with respiratory insufficiency syndrome secondary to pneumonia caused by SARS Co2. In the next days, he developed rapid neurological deterioration characterized by drowsiness which progressed to deep coma. D-dimer was elevated. Brain CT scan showed bilateral massive ischemic stroke located in the anterior circulation, CT angiogram showed occlusion in the left internal carotid artery and the right middle cerebral artery.
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Luis A. Robles Tags: Case Report Source Type: research

COVID-19 encephalitis with SARS-CoV-2 detected in cerebrospinal fluid presenting as a stroke mimic
We report the case of a 35-year-old male with COVID-19 encephalitis presenting as a stroke mimic with sudden-onset expressive and receptive dysphasia, mild confusion and right arm incoordination. The patient received thrombolysis for a suspected ischaemic stroke, but later became febrile and SARS-CoV-2 was detected in cerebrospinal fluid. Electroencephalography demonstrated excess in slow waves, but neuroimaging was reported as normal. Respiratory symptoms were absent throughout and nasopharyngeal swab was negative for SARS-CoV-2.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2021 Category: Neurology Authors: Diarmuid Glavin, Denise Kelly, Greta Karen Wood, Beth MS McCausland, Mark Alexander Ellul, Aravinthan Varatharaj, Ian Galea, Rhys Huw Thomas, Benedict Daniel Michael, Brian Gallen, CoroNerve Study Management Group Tags: Case Report Source Type: research

Utilization and Outcomes of Acute Revascularization Treatment in Ischemic Stroke Patients with SARS-CoV-2 Infection
Our understanding of outcomes in acute ischemic stroke patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection following acute revascularization treatments (as intravenous thrombolysis and/or thrombectomy) is based on small case series.1-3. An international panel4 cautioned regarding the potential for high rate of death or disability and post thrombolytic intracerebral hemorrhage (ICH)s in acute ischemic stroke patients with SARS-CoV-2 infection due to elevated concentrations of inflammation and hypercoagulability markers such as leukocytosis, and C reactive protein and D dimers and multisystem dysfunction.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2021 Category: Neurology Authors: Adnan I. Qureshi, William I. Baskett, Wei Huang, Muhammad F. Ishfaq, S. Hasan Naqvi, Brandi R. French, Farhan Siddiq, Camilo R. Gomez, Chi-Ren Shyu Tags: SARS-CoV-2 and acute revascularization Source Type: research

Utilization and Outcomes of Acute Revascularization Treatments in Ischemic Stroke Patients with SARS-CoV-2 Infection
Our understanding of outcomes in acute ischemic stroke patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection following acute revascularization treatments (as intravenous thrombolysis and/or thrombectomy) is based on small case series.1 –3 An international panel4 cautioned regarding the potential for high rate of death or disability and post thrombolytic intracerebral hemorrhage (ICH)s in acute ischemic stroke patients with SARS-CoV-2 infection due to elevated concentrations of inflammation and hypercoagulability markers such as leukocytosis, and C reactive protein and D dimers and multisystem dysfunction.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2021 Category: Neurology Authors: Adnan I. Qureshi, William I. Baskett, Wei Huang, Muhammad F. Ishfaq, S. Hasan Naqvi, Brandi R. French, Farhan Siddiq, Camilo R. Gomez, Chi-Ren Shyu Source Type: research

Stroke and COVID19: not only a large-vessel disease
Recent evidence has underlined the association between large-vessel stroke and COVID-19, probably due to a proinflammatory and prothrombotic microenvironment induced by SARS-CoV-2. Here, we report the case of a young fit woman affected by COVID-19 without any flu-like symptom, who suffered from speech disorder and left hemiparesis. Brain magnetic resonance evidenced two small acute brain infarctions in right perirolandic cortex without signs of previous ischemic lesions and hemorrhagic infarction.
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2020 Category: Neurology Authors: Giovanni Frisullo, Simone Bellavia, Irene Scala, Carla Piano, Roberta Morosetti, Valerio Brunetti, Paolo Calabresi, Giacomo Della Marca Tags: Case Report Source Type: research

Time of stroke onset in Coronavirus disease 2019 patients around the globe: a systematic review and analysis.
Coronavirus disease 2019 (COVID-19) rapidly became a pandemic. As of August 29th, 2020, over 24 million cases have been confirmed worldwide1. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection is associated with diverse neurological manifestations involving both the central and peripheral nervous system2,3. In fact, reports of ischemic stroke in patients with COVID-19 have increasingly been published, suggesting an association between these conditions. It has been proposed that SARS-CoV-2 infection induces a severe inflammatory response and hypercoagulable state, making patients susceptible to thromboti...
Source: Journal of Stroke and Cerebrovascular Diseases - September 17, 2020 Category: Neurology Authors: Natalia Valencia-Enciso, M ónica Ortiz-Pereira, María Paula Zafra-Sierra, Laura Espinel-Gómez, Hernan Bayona Source Type: research

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