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A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial
Several studies evaluating clinical forms of chronic Chagas disease show that about one-third of patients present cardiac involvement. Heart failure, sudden death and cardioembolic stroke are the main mechanis...
Source: Trials - September 19, 2018 Category: General Medicine Authors: Marcelo Teixeira Holanda, Mauro Felippe Felix Mediano, Alejandro Marcel Hasslocher-Moreno, S érgio Salles Xavier, Roberto Magalhães Saraiva, Andrea Silvestre Sousa, Erica Rodrigues Maciel, Fernanda Martins Carneiro, Paula Simplicio da Silva, Luiz Henriq Tags: Update Source Type: research

Chagas disease
Publication date: Available online 30 June 2017 Source:The Lancet Author(s): José A Pérez-Molina, Israel Molina Chagas disease is an anthropozoonosis from the American continent that has spread from its original boundaries through migration. It is caused by the protozoan Trypanosoma cruzi, which was identified in the first decade of the 20th century. Once acute infection resolves, patients can develop chronic disease, which in up to 30–40% of cases is characterised by cardiomyopathy, arrhythmias, megaviscera, and, more rarely, polyneuropathy and stroke. Even after more than a century, many challenges remain unresolved...
Source: The Lancet - July 1, 2017 Category: General Medicine Source Type: research

Seminar Chagas disease
Chagas disease is an anthropozoonosis from the American continent that has spread from its original boundaries through migration. It is caused by the protozoan Trypanosoma cruzi, which was identified in the first decade of the 20th century. Once acute infection resolves, patients can develop chronic disease, which in up to 30 –40% of cases is characterised by cardiomyopathy, arrhythmias, megaviscera, and, more rarely, polyneuropathy and stroke. Even after more than a century, many challenges remain unresolved, since epidemiological control and diagnostic, therapeutic, and prognostic methods must be improved.
Source: LANCET - June 30, 2017 Category: General Medicine Authors: Jos é A Pérez-Molina, Israel Molina Tags: Seminar Source Type: research

The potential influence of atherogenic dyslipidemia on the severity of chronic Chagas heart disease
Conclusion: we observed that AI correlated with CCHD stages and contributed, in association with anti-B13 antibodies and age, to the prediction of systolic heart failure.RESUMO Introducción: la miocardiopatía chagásica (MCC) es la manifestación más común de la tripanosomiasis americana, causando cerca de 50.000 muertes al año. Varios factores se asocian con la gravedad de MCC. Sin embargo, la evaluación de la contribución de los principales factores de riesgo cardiovascular (FRC), como la hipertensión y la dislipidemia aterogénica (DA), a la gravedad de la MCC es escasa, a pesar de su papel bien establecido en l...
Source: Revista da Associacao Medica Brasileira - March 23, 2016 Category: Journals (General) Source Type: research

Selenium Treatment and Chagasic Cardiopathy (STCC): study protocol for a double-blind randomized controlled trial
DiscussionIf Se treatment reduces the progression of Chagas cardiopathy, the inclusion of this micronutrient in the daily diet can improve the therapeutic regimen for this neglected tropical disease at low cost.Trial registration: Clinical Trials.gov ID: NCT00875173 (registered 20 October 20 2008).
Source: Trials - October 6, 2014 Category: Journals (General) Authors: Pedro Alvarenga Americano do BrasilAndréa Pereira de SouzaAlejandro Hasslocher-MorenoSérgio XavierSonia Lambert PassosMaria de Fátima Ramos MoreiraMarília Santini de OliveiraGilberto Sperandio da SilvaRoberto Magalhães SaraivaClaudia Santos de Aguiar Source Type: research