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Comprehensive analysis of transcriptome-wide expression patterns and a circRNA/lncRNA-miRNA-mRNA network in the pathogenesis of cerebral ischemia in Rattus norvegicus
CONCLUSIONS: Through bioinformatic network analysis, we identified the underlying molecular mechanisms and key central genes that may contribute to an inflammatory response after cerebral infarction.PMID:37056868 | PMC:PMC10086920
Source: Cell Research - April 14, 2023 Category: Cytology Authors: Yun-Hong Yang Hai-Tao Tian Xing-Fang Jin Dan Zhou Yan-Mei Ji Wen-Jun Li Lang Fang Source Type: research

CMV seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study
Summary Although chronic infection with cytomegalovirus (CMV) is known to drive T lymphocytes toward a senescent phenotype, it remains controversial whether and how CMV can cause coronary heart disease (CHD). To explore whether CMV seropositivity or T‐cell populations associated with immunosenescence were informative for adverse cardiovascular outcome in the very old, we prospectively analyzed peripheral blood samples from 751 octogenarians (38% males) from the Newcastle 85+ study for their power to predict survival during a 65‐month follow‐up (47.3% survival rate). CMV‐seropositive participants showed a higher pre...
Source: Aging Cell - December 22, 2015 Category: Cytology Authors: Ioakim Spyridopoulos, Carmen Martin‐Ruiz, Catharien Hilkens, Mohammad E. Yadegarfar, John Isaacs, Carol Jagger, Tom Kirkwood, Thomas Zglinicki Tags: Short Take Source Type: research