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Simplified classification of cavernous internal carotid artery tortuosity: a predictor of procedural complexity and clinical outcomes in mechanical thrombectomy
CONCLUSIONS: The study indicated that the grading of cICA tortuosity is highly correlated with procedural complexity and clinical outcome in mechanical thrombectomy. The proposed classification system may be helpful in pre-procedure prognostication complexity and clinical outcomes.Abbreviations:LVS: large vessel stroke; cICA: cavernous internal carotid artery; mRS: modified Rankin Scale; AIS: acute ischemic stroke; MCA: middle cerebral artery; M1: first division of middle cerebral artery; M2: second division of middle cerebral artery; M3: third division of middle cerebral artery; TICI: Thrombolysis In Cerebral Infarction; ...
Source: Neurological Research - April 27, 2022 Category: Neurology Authors: Zhongjun Chen Tieping Fan Xusheng Zhao Teng Hu Hengxu Qi Di Li Source Type: research

Direct angiographic intervention for acute ischemic stroke with large vessel occlusion
Conclusion:This new approach may provide benefits for appropriately selected patients. Further prospective trials are needed to clarify the risk-versus-benefit of this approach.Abbreviations and Acronyms: AHA: American Heart AssociationAIS: acute ischemic strokeASA: American Stroke AssociationASPECTS: Alberta Stroke Program Early Computed Tomography ScoreCT: computed tomographyCTA: computed tomography angiographyCTP: computed tomography perfusionDMVO: distal, medium vessel occlusionDSA: digital subtraction angiographyED: Emergency DepartmentEVT: endovascular thrombectomyFD: flat detectorIA: intra-arterialIV: intravenousICH...
Source: Neurological Research - June 16, 2021 Category: Neurology Authors: Weizhe Li W Scott Burgin Kanita Beba Abadal Maxim Mokin Zeguang Ren Source Type: research

Matrix metallopeptidase 9 and placental growth factor may correlate with collateral status based on whole-brain perfusion combined with multiphase computed tomography angiography
DISCUSSION: Serum PGF and MMP-9 levels may correlate with collateral status based on MP-CTA in acute ischemic stroke patients with cerebral large artery atherosclerosis. Higher PGF and MMP-9 concentration associated with good collateral status.PMID:34107864 | DOI:10.1080/01616412.2021.1939238
Source: Neurological Research - June 10, 2021 Category: Neurology Authors: Bo Yang Yarong Ding Xin Liu Yuan Cai Xinxuan Yang Qixuan Lu Weibin Gu Liping Liu Yuehua Pu Source Type: research

Evaluation of intracranial and extracranial atherosclerotic lesions in patients with symptomatic coronary artery disease.
Conclusions: The prevalence of ECAD, ICAD and EICAD is high in patients with CAD, and the presence of these conditions is positively correlated with the extent and degree of CAD. Evaluations of ECAD and ICAD should be highly recommended for CAD patients to reduce the future risk of cardiovascular diseases. PMID: 32284016 [PubMed - as supplied by publisher]
Source: Neurological Research - April 16, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Effect of a novel designed intensive patient care program on cognitive impairment, anxiety, depression as well as relapse free survival in acute ischemic stroke patients: a randomized controlled study.
Conclusions: IPCP presents with a positive influence on improving cognitive impairment and decreasing anxiety as well as depression, while a less effect on improving RFS in AIS patients. Abbreviation: IPCP: intensive patient care program; RFS: relapse free survival; AIS: acute ischemic stroke; MRA: magnetic resonance angiography; ITT: intention-to-treat; LOCF: last observation carried forward. PMID: 31266412 [PubMed - as supplied by publisher]
Source: Neurological Research - July 4, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Balloon-mounted versus self-expanding stents for symptomatic intracranial vertebrobasilar artery stenosis combined with poor collaterals.
CONCLUSIONS: Stenting for patients with severe symptomatic intracranial vertebrobasilar arterial stenosis with poor collaterals can be performed safely with efficacy. Patients treated with balloon-mounted stents appear to have shorter operative times and lower re-stenosis rates than treated with self-expanding stents. PMID: 31030623 [PubMed - as supplied by publisher]
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Early microalbuminuria as a clinical marker for acute cerebral small vessel infarction.
CONCLUSIONS: These findings demonstrate that in patients with acute lacunar infarction, slightly increased microalbuminuria seems to be a potential clinical marker for CSVD. The presence of microalbuminuria early may help to differentiate CSVD from stroke subtypes. PMID: 30475173 [PubMed - as supplied by publisher]
Source: Neurological Research - November 27, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Real-world treatment of large vessel occlusions: combined outcomes of directly presenting and transferred-in patients to a stroke center.
Conclusion High rates of favorable angiographic and clinical outcomes were found among AIS patients receiving ET in our single-center experience, particularly among transferred in patients. The establishment of a stroke network may help in the efficient transfer and assembly of appropriate resources for eligible patients that are transferred in for ET. PMID: 29683786 [PubMed - as supplied by publisher]
Source: Neurological Research - April 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Collateral circulation alters downstream hemodynamic stress caused by intracranial atherosclerotic stenosis.
CONCLUSION: An anatomically severe (70-99%) symptomatic ICAS lesion may generate significant hemodynamic stress downstream as assessed by the indicator FF, particularly in patients with poor collateral circulation. Further, good collateralization may mitigate this hemodynamic impact, partially explaining the protective effect of collateral circulation against recurrent stroke in such patients. PMID: 28436268 [PubMed - as supplied by publisher]
Source: Neurological Research - April 25, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Carotid artery disease and low cerebral perfusion pressure: symptomatology, operative risk and outcome.
Authors: Schroeder T, Utzon NP, Aabech J, Sillesen H, Sørensen PS, Engell HC Abstract Direct internal carotid artery blood pressure measurements in patients undergoing carotid endarterectomy identified 49 patients, among 239 consecutive cases (21%), who had a reduction in perfusion pressure of 20% or more. The clinical history, objective findings and angiographic data were compared with those of a control group of a further 49 patients selected from the remaining patients operated on over the same period. The two groups were compared for short- and long-term outcome of surgery. We were unable to delineate a sympto...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research

A modified method to reduce variable outcomes in a rat model of four-vessel arterial occlusion.
CONCLUSIONS: In conclusion, this modified model provides a reliable tool for ischemic stroke research. PMID: 27796195 [PubMed - as supplied by publisher]
Source: Neurological Research - November 1, 2016 Category: Neurology Tags: Neurol Res Source Type: research

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