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Evaluating the effect of transplanting umbilical cord matrix stem cells on ischemic tolerance in an animal model of stroke.
CONCLUSION: The pretreatment of the transplanted umbilical cord stem cells in the striatum of ischemic rats possibly leads to restorative events, exerting a decreasing effect on cell death. Subsequently, these events may improve the motor ability and reduce ischemic injuries. PMID: 33167823 [PubMed - as supplied by publisher]
Source: Neurological Research - November 12, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotection by intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats in a model of ischemic stroke.
This study was undertaken to further explore the potential mechanisms underlying the neuroprotective effects of BMRMNCs in the same model. Rats were intravenously pre-treated with 5-FU, and BMRMNCs were collected 7 days later and subjected to flow cytometry for detection of CD34, CD45 and CD90. Middle cerebral artery occlusion (MCAO) was induced in rats, and BMMNCs and BMRMNCs were independently transplanted via the tail vein at 24 h after MCAO. NISSL staining was performed 14 days after cell transplantation and the viable cells in the hippocampus were counted. Stromal cell-derived factor 1 (SDF-1) mRNA expression was d...
Source: Neurological Research - August 4, 2016 Category: Neurology Tags: Neurol Res Source Type: research