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Intracranial hemorrhage in large vessel occlusion patients receiving endovascular thrombectomy with or without intravenous alteplase: a secondary analysis of the DIRECT-MT trial
Conclusions Our data showed that in the DIRECT-MT trial, alteplase did not increase overall ICH for large vessel occlusion patients treated with thrombectomy, but it increased the parenchymal hematoma rate.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Hu, X., Zhou, Y., Ospel, J., Yao, F., Liu, Y., Wang, H., Li, B., Hui, P., Yang, P., Zhang, Y., Zhang, L., Li, Z., Xing, P., Shi, H., Han, H., Wang, S., Fang, Q., Liu, J., for the Direct-MT investigators Tags: Open access, Ischemic stroke Source Type: research

Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial
Conclusion The effect of SBP lowering treatment was not modified by age, location of occlusion history of hypertension, intravenous thrombolysis, and admission SBP. Diabetes modified the effect of intensive SBP lowering treatment, and there was a trend towards benefit from intensive SBP treatment in diabetic patients. This finding is hypothesis generating and requires further validation.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Anadani, M., Maier, B., Escalard, S., Labreuche, J., de Havenon, A., Sabben, C., Lapergue, B., Mistry, E. A., Gory, B., Spiotta, A. M., Richard, S., Sibon, I., Desilles, J.-P., Blanc, R., Piotin, M., Mazighi, M., of behalf the BP TARGET study group, Mazig Tags: Ischemic stroke Source Type: research

P146/118 NeVa ONE registry interim analysis: recanalization outcomes from a large, real-world patient cohort
ConclusionNeVa ONE Registry represents real-world data obtained from LVO AIS subjects treated with NeVa.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Bhogal, P., Diaz, J., Gallego, J. I., Dopico, M. S., Pfaff, J., Behme, D., Pero, G., Voormolen, M., John, S., Romero Florez, N. A., Celma, S. M., Waele, T. d., Francois, O., Cotroneo, E., Maleux, G. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P008/85 Transarterial embolization (including hypoglossal artery) of dural arteriovenous fistula with multiple venous varices: Case report
ConclusionDAVF with venous varix is defined as high risk for venous hypertension or hemorrhage. There is a possibility of lower CN injury during embolization for hypoglossal artery, so accurate knowledge of anatomical structures is essential. Transarterial embolization for DAVF with large venous varix is a safe and considerable treatment option, even when fed by hypoglossal artery.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Lee, J., Yang, J.-C., Hong, C. E., Han, M. H. Tags: 4.3 CASE PROPOSAL - Acute ischemic stroke Source Type: research

E-086 The effect of covid-19 vaccines on stroke outcomes: a single-center study
ConclusionAlthough vaccination did not show any significant difference in stroke patient outcomes on follow-up, vaccines were associated with lower rates of morbidity and mortality at discharge among stroke patients during the pandemic.Abstract E-086 Table 1Comparison of outcomes between COVID-19-positive unvaccinated vs. fully vaccinated patients presenting with stroke.*Adjusted for hypertension, atrial fibrillation, PVD, admission NIHSS, ASPECTS, tandem occlusion, and thrombectomy Unvaccinated Vaccinated Effect Variable Unadjusted Value (95% CI ) Unadjusted p-value Adjusted Value (95% CI )* Adjusted p-value* Primary Out...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: El Naamani, K., Amllay, A., Chen, C., Capone, S., Abbas, R., Sioutas, G., Munoz, A., Yudkoff, C., Carreras, A., Samabngi, A., Hunt, A., Jain, P., Stine, E., Sathe, A., Smit, R., Yazbeck, F., Tjoumakaris, S., Gooch, M., Herial, N., Rosenwasser, R., Zarzour Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-093 Carotid webs and stroke: a comprehensive overview of clinical characteristics, risk factors, and treatment modalities
ConclusionThis is the largest systematic review of CWs to date. This study provides novel information not only about risk factors and common treatment modalities for CWs, but also the relationship between CWs and stroke. This data may aid physicians in diagnosis of CWs in younger patients who present with stroke-like symptoms and no cardiovascular risk factors. Furthermore, medical treatment alone may not be as effective as stenting or surgical options.Disclosures N. Gupta: None. V. Kasulla: None. A. Shahbandi: None. J. Gendreau: None. R. Singh: None. N. Brown: None. J. Catapano: None. V. Srinivasan: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Gupta, N., Kasulla, V., Shahbandi, A., Gendreau, J., Singh, R., Brown, N., Catapano, J., Srinivasan, V. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-108 Endovascular treatment of patients with acute ischemic stroke due to underlying arterial dissection: a nationwide analysis
ConclusionsDespite a similar prevalence among patients admitted for AIS, CA dissections are associated with a higher rate of endovascular intervention and poorer short-term outcomes compared to VA dissections. This study provides essential epidemiologic and outcome data for the cerebrovascular neurosurgeon.Abstract E-108 Table 1Comparison of clinical characteristics and outcomes among patients presenting with acute ischemic stroke due to carotid or vertebral artery dissections Characteristic Vertebral Artery Dissection, N = 2,562 Carotid Artery Dissection, N = 2,789 p-value1 Age (years), Mean (SD) 53 (17) 57 (17) <0.00...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Brandel, M., McCann, C., Wali, A., Wu, V., Esmail, S., Steinberg, J., Olson, S., Pannell, J., Khalessi, A., Santiago-Dieppa, D. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-110 Bilateral hypoplasia of the internal carotid artery (ICA) and intracranial vasculopathy with 'moyamoya phenomenon in association with alagille syndrome
ConclusionThe educational value of our case lies not only in the rarity of the condition but also in the uniqueness of patient presentation. It would be a helpful addition to the existing literature on rare genetic syndromes with cerebral vasculature involvement.Abstract E-110 Figure 1Disclosures H. Shakeel: None. J. Gandhi: None. R. Singh: None. A. Graziano: None. R. Cerejo: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Shakeel, H., Gandhi, J., Singh, R., Graziano, A., Cerejo, R. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-126 Multicenter flow diversion in 200 patients for treatment of intracranial aneurysms
ConclusionThis report characterizes patient demographics, aneurysm characteristics, procedure complications and long-term angiographic and clinical outcomes for a large patient population across multiple medical centers treated with flow diversion. Overall, procedures resulted in a high rate of occlusion and low rate of serious complications. Continued iterative outcomes analysis is warranted particularly as flow diversion technology evolves. Despite diverse hospital settings, differences in presentation, patient characteristics and the inclusion of off-label treatments, flow diversion procedures remained safe and effectiv...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Meister, R., Lesko, A., Marginean, H., Deshmukh, V. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-135 Dejerine-roussy syndrome in the setting of right sigmoid sinus thrombosis: a unique case report
DiscussionThis case illustrates the important clinical aspects and physical findings needed to diagnose DRS. The presence of focal allodynia and hyperalgesia with recent cerebrovascular incidents provides significant evidence for DRS. The purpose of this case is to provide awareness and to increase clinical suspicion of DRS during examination, especially in the setting of cerebral venous sinus occlusion as infarction alone may not present as atypical allodynia.Disclosures S. Nittala: None. C. Jara: None. D. Raza: None. J. Cazzaniga: None. D. Filippi: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Nittala, S., Jara, C., Raza, D., Cazzaniga, J., Filippi, D. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

O-001 Trends in endovascular mechanical thrombectomy for acute ischemic stroke: a regional comparison analysis using United States national inpatient sample data
ConclusionsThere remain significant regional differences in the outcomes of EVT for AIS. More analysis is required to determine what is driving these differences. More work is needed to ensure optimal and equitable patient outcomes.Abstract O-001 Table 1 Characteristic (p value) East North Central East South Central Middle Atlantic Mountain New England Pacific South Atlantic West North Central West South Central Age in Years Mean (±SD)(p<0.001) 68.69 ± 14.43 67.04 ± 14.85 70.09 ± 14.39 68.72 ± 14.53 70.27 ± 14.92 70.26 ± 14.51 68.81 ± 14.29 69.21 ± 14.51 67...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Brake, A., Fry, L., LeBeau, G., Heskett, C., Lei, C., Alkiswani, A., Le, K., De-Stefano, F., Peterson, J., Ebersole, K. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

O-040 Initial clinical experience with the bendit steerable articulating tip microcatheter for intracranial access and intervention
ConclusionsInitial clinical experience with the controlled articulation that permits flexion at the tip of the microcatheter demonstrated it to be safe. Access to difficult proximal origin curves, and distal clinoidal/ophthalmic segment anatomy may be improved due to the high torque transmission, and acute angulation of this microcatheter. Further experience with the delivery of therapeutic devices will be necessary to better understand the potential role that the present catheter may play in modern neurointerventional procedures.Abstract O-040 Table 1 Patient/Indication/Comorbidities/Treatment/Bendit 21 Role 60s F Cerebr...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Qiao, Y., Zhang, Y., Tsappidi, S., Mehta, T., Hui, F. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

P-026 Extracellular vesicle neurotrophin expression in plasma collected during mechanical thrombectomy from patients with emergent large vessel stroke
DiscussionThese data suggest that EV proBDNF/BDNF levels can reflect vascular changes that lead to decreased cognition and should be explored further for translational applications.Disclosures A. Trout: None. D. Britsch: None. W. Naberhaus: None. J. Turchan-Cholewo: None. C. McLouth: None. L. Whitnel-Smith: None. J. Frank: None. J. Roberts: None. P. Shivani: None. D. Dornboss III: None. J. Harp: None. K. Pennypacker: None. A. Stowe: None. J. Fraser: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Trout, A., Britsch, D., Naberhaus, W., Turchan-Cholewo, J., McLouth, C., Whitnel-Smith, L., Frank, J., Roberts, J., Shivani, P., Dornboss, D., Harp, J., Pennypacker, K., Stowe, A., Fraser, J. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

E-020 Flow diversion for intracranial aneurysms: intracranial hemorrhage and thromboembolic complications in a multi-center cohort of 200 patients
ConclusionComplication rates in our study are comparable to previous reports, and our findings further support the general safety and efficacy of flow diversion. Despite a relatively large population, the low number of ICH and TE complications limit statistical significance. Further study of complications in more robust samples are needed. However, the descriptive understanding of these complications can help direction future investigations.Abstract E-020 Table 1ICH and TE Stratifications ICH Non-ICH p n=7 n=193 Hypertension 7 (100%) 97 (50.3%) 0.035 Currently Smoking 3 (42.9%) 28 (14.5%) 0.319 Mean Procedural Fluoroscopi...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Meister, R., Lesko, A., Marginean, H., Deshmukh, V. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-065 Interim safety and occlusion outcomes of endovascular treatment of large intracranial aneurysms in the sterling registry
ConclusionEarly results from the STERLING registry for large aneurysms are promising. Adequate occlusion per Independent Core Lab was achieved in 86.7% and retreatment rates were relatively low over 1-year follow-up. A good functional outcome was achieved in 85.7% of patientsDisclosures O. Zaidat: 1; C; Stryker, Medtronic, Cerenovus, Penumbra, and Genentech. 2; C; Stryker, Medtronic, Cerenovus, Penumbra, and Neuravi. 4; C; ownership interest in Galaxy Therapeutics LLC;. 6; C; honoraria from Codman,Stryker,Penumbra, Medtronic. serves on the endovascular committee as co-chair for NIH StrokeNet Consortium; has served as an ex...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Zaidat, O., Ashouri, Y., Starke, R., Puri, A., Jankowitz, B., Yoo, A., Marnat, G., Kulcsar, Z., Sugiu, K., Jahshan, S., Machi, P., Pero, G., Castro, S., Howington, J., Schirmer, C., Kilburg, C., Chivot, C., Al-Mufti, F., Da Ros, V., Gory, B., Yao, T., Pol Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

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