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The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction
As the most common type of stroke, ischemic stroke, also known as cerebral infarction (CI), with its high mortality and disability rate, has placed a huge burden on social economy and public health. Treatment methods for CI mainly include thrombectomy, thrombolysis, drug therapy, and so on. However, these treatments have certain timeliness and different side effects. In recent years, the gut-brain axis has become a hot topic, and its role in nervous system diseases has been confirmed by increasing evidences. The intestinal microbiota, as an important part of the gut-brain axis, has a non-negligible impact on the progressio...
Source: Frontiers in cellular and infection microbiology - January 25, 2023 Category: Microbiology Source Type: research

Multi-omics reveals specific host metabolism-microbiome associations in intracerebral hemorrhage
In conclusion, microbiome-related metabolites in ICH patients was associated with the severity of ICH, the microbiota-host co-metabolites may be a potential may be potential therapeutic targets.
Source: Frontiers in cellular and infection microbiology - December 22, 2022 Category: Microbiology Source Type: research

Gut microbiota signature as predictors of adverse outcomes after acute ischemic stroke in patients with hyperlipidemia
ConclusionsThese findings revealed the microbial characteristics of POAH, which highlighted the predictive capability of characteristic microbiota in POAH patients.
Source: Frontiers in cellular and infection microbiology - November 24, 2022 Category: Microbiology Source Type: research

Comprehensive evaluation of the mechanism of Gastrodia elata Blume in ameliorating cerebral ischemia –reperfusion injury based on integrating fecal metabonomics and 16S rDNA sequencing
Gastrodia elata Blume was used to treat stroke and headaches caused by “Feng” for thousands of years. The present study has shown a significant effect of G. elata Blume in improving cerebral ischemia–reperfusion injury (CIRI). However, the mechanism of G. elata Blume in improving CIRI by regulating the intestinal flora has not been reported until now. This research aimed to comprehensively evaluate the mechanism of G. elata Blume in CIRI based on fecal metabolomics and 16S rDNA sequencing. The rat model with CIRI was created based on the Zea Longa method. Enzyme-linked immunosorbent assay (ELISA) was used to monitor ...
Source: Frontiers in cellular and infection microbiology - October 27, 2022 Category: Microbiology Source Type: research

The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation
In the last two decades, considerable interest has been shown in understanding the development of the gut microbiota and its internal and external effects on the intestine, as well as the risk factors for cardiovascular diseases (CVDs) such as metabolic syndrome. The intestinal microbiota plays a pivotal role in human health and disease. Recent studies revealed that the gut microbiota can affect the host body. CVDs are a leading cause of morbidity and mortality, and patients favor death over chronic kidney disease. For the function of gut microbiota in the host, molecules have to penetrate the intestinal epithelium or the ...
Source: Frontiers in cellular and infection microbiology - June 20, 2022 Category: Microbiology Source Type: research

Neuroinflammation, Sleep, and Circadian Rhythms
Molecules involved in innate immunity affect sleep and circadian oscillators and vice versa. Sleep-inducing inflammatory molecules are activated by increased waking activity and pathogens. Pathologies that alter inflammatory molecules, such as traumatic brain injury, cancer, cardiovascular disease, and stroke often are associated with disturbed sleep and electroencephalogram power spectra. Moreover, sleep disorders, such as insomnia and sleep disordered breathing, are associated with increased dysregulation of inflammatory processes. Inflammatory molecules in both the central nervous system and periphery can alter sleep. I...
Source: Frontiers in cellular and infection microbiology - March 22, 2022 Category: Microbiology Source Type: research

Integrated Traditional Chinese Medicine Improves Functional Outcome in Acute Ischemic Stroke: From Clinic to Mechanism Exploration With Gut Microbiota
This study analyzed clinical and gut microbial data and revealed the possibility of a broad application independent of the enterotypes, as well as the therapeutic targets of the ITCM in treating AIS patients with phlegm-heat syndrome.
Source: Frontiers in cellular and infection microbiology - February 9, 2022 Category: Microbiology Source Type: research

Roseburia Abundance Associates With Severity, Evolution and Outcome of Acute Ischemic Stroke
Stroke induces disorder of gut microbiota, however, whether this disorder differs according to stroke severity and its role in the evolution and outcome of stroke is currently unknown. Here we explored the composition and structure of fecal microbiome based on 68 acute ischemic stroke patients presenting with minor symptoms (admission National Institute of Health Stroke Scale (NIHSS) ≤ 3) and 67 patients with non-minor stroke (admission NIHSS 4-34) using high-throughput Illumina sequencing of the 16S rRNA. There was no significant difference in α-diversity indices, but the principal coordinate analysis of the microbiota...
Source: Frontiers in cellular and infection microbiology - October 19, 2021 Category: Microbiology Source Type: research

The Impact of Gut Microbiota on Post-Stroke Management
Source: Frontiers in cellular and infection microbiology - October 12, 2021 Category: Microbiology Source Type: research

Dysbiosis of Gut Microbiota Is an Independent Risk Factor of Stroke-Associated Pneumonia: A Chinese Pilot Study
ConclusionWe demonstrate that a microbial community with depleted Roseburia and enriched opportunistic pathogens is associated with increased risk of SAP among AIS patients. Gut microbiota screening might be useful for identifying patients at high risk for SAP and provide clues for stroke treatment.
Source: Frontiers in cellular and infection microbiology - August 3, 2021 Category: Microbiology Source Type: research

Characterization of an Enterococcus faecalis Bacteriophage vB_EfaM_LG1 and Its Synergistic Effect With Antibiotic
Enterococcus faecalis is a Gram-positive opportunistic pathogen that could cause pneumonia and bacteremia in stroke patients. The development of antibiotic resistance in hospital-associated E. faecalis is a formidable public health threat. Bacteriophage therapy is a renewed solution to treat antibiotic-resistant bacterial infections. However, bacteria can acquire phage resistance quite quickly, which is a significant barrier to phage therapy. Here, we characterized a lytic E. faecalis bacteriophage Vb_EfaM_LG1 with lytic activity. Its genome did not contain antibiotic resistance or virulence genes. Vb_EfaM_LG1 effectively ...
Source: Frontiers in cellular and infection microbiology - July 16, 2021 Category: Microbiology Source Type: research

Lactulose Improves Neurological Outcomes by Repressing Harmful Bacteria and Regulating Inflammatory Reactions in Mice After Stroke
ConclusionLactulose promotes functional outcomes after stroke in mice, which may be attributable to repressing harmful bacteria, and metabolic disorder, repairing gut barrier disruption, and reducing inflammatory reactions after stroke.
Source: Frontiers in cellular and infection microbiology - July 13, 2021 Category: Microbiology Source Type: research

Alteration of Gut Microbiome and Correlated Lipid Metabolism in Post-Stroke Depression
ConclusionsOur findings suggest that gut microbiome may participate in the development of PSD, the mechanism may be related to the regulation of lipid metabolism.
Source: Frontiers in cellular and infection microbiology - April 22, 2021 Category: Microbiology Source Type: research

Gut Microbiotic Features Aiding the Diagnosis of Acute Ischemic Stroke
This study is the first to characterize the gut microbiotic profiles of patients with lacunar or non-lacunar, acute ischemic strokes, and those recovering from stroke, and to identify microbiotic predictors of such strokes.
Source: Frontiers in cellular and infection microbiology - December 21, 2020 Category: Microbiology Source Type: research

Fecal Microbiota Transplantation in Neurological Disorders
Conclusions: Preliminary literature suggests that FMT may be a promising treatment option for several neurological disorders. However, available evidence is still scanty and some contrasting results were observed. A limited number of studies in humans have been performed or are ongoing, while for some disorders only animal experiments have been conducted. Large double-blinded randomized controlled trials are needed to further elucidate the effect of FMT in neurological disorders.
Source: Frontiers in cellular and infection microbiology - March 23, 2020 Category: Microbiology Source Type: research

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