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Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health
There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background. We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients identified using nationwide health registries. We estimated 0.08 (95% CI 0.06–0.11) heritability and identified five loci associated with OSA (p<5.0x10–8): rs4837016 near GAPVD1 (GTPase activating protein and VPS9 domains 1), rs1092856...
Source: European Respiratory Journal - May 6, 2021 Category: Respiratory Medicine Authors: Strausz, S., Ruotsalainen, S., Ollila, H. M., Karjalainen, J., Kiiskinen, T., Reeve, M., Kurki, M., Mars, N., Havulinna, A. S., Luonsi, E., Mansour Aly, D., Ahlqvist, E., Teder-Laving, M., Palta, P., Groop, L., Mägi, R., Mäkitie, A., Salom Tags: Sleep medicine Original Articles: Sleep medicine Source Type: research

Stroke volume change after digoxin loading in septic shock patients with transient left ventricular systolic dysfunction.
In conclusion, in septic shock patients with transient LV dysfunction such as TS, digoxin loading can be a feasible treatment. Further clinical study is needed. Before Digoxin LoadingAfter Digoxin LoadingpEjection Fraction (%)20.2 ± 9.422.2 ± 10.40.327Time-Velocity Integral (cm)10.8 ± 3.112.3 ± 4.60.093LVOT diameter (cm)1.82 ± 0.241.88 ± 0.260.025Stroke Volume (mL)27.6 ± 7.933.7 ± 11.90.048
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lee, D. H., Jeong, J.-H., Kang, B. H., Um, S., Son, C. Tags: Acute Critical Care Source Type: research