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COPD and COVID-19: a dangerous association?
Conclusion: COPDs patients are mostly ederly men with comorbidities. The most effective treatment for them was stabilization of comorbidities and conventional oxygen and for the most severe Helmet-CPAP and NIV. In addition, COPD patients had no higher risk of mortality from COVID-19 than individuals without a pre-existing diagnosis of COPD.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mendez Gonzalez, L., Ferreira, J., Caneiras, C. Tags: 05.02 - Monitoring airway disease Source Type: research

Comorbidities in patients with Obstructive Sleep Apnea syndrome (OSAS) in Reunion Island.
Conclusion: Morbid obesity, hypertension, diabetes, heart disease and respiratory illness are a predictor of severe OSAS in our patients especially snorers.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Omarjee, B., Budhan, S., Kichenin, C., Omarjee, A., Vellin, J. F. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research

Interrelationships between body mass index, total IgE, and blood eosinophils count in healthy subjects
Conclusion: This study showed an independent relationship between B-Eos count and total IgE in healthy subjects. When adjusted for total IgE, the association between B-Eos count and BMI disappeared whereas the association with current smoking remained, indicating possible different mechanisms underlying increased B-Eos count upon these exposures.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Amaral, R., Jacinto, T., Malinovschi, A., Janson, C., Price, D., Fonseca, J., Alving, K. Tags: 05.03 - Allergy and immunology Source Type: research

Hospitalizations in OSA patients
Obstructive sleep apnea (OSA) is associated with cardiovascular comorbidities and other chronic diseases, accounting for long-term morbidity, with elevated symptomatic burden and hospitalizations. We aim to study the hospitalizations' causes in OSA patients and its relation to OSA severity and PAP therapy adhesion.This is a retrospective study including 281 hospitalizations corresponding to 200 OSA patients during 2019. Mean age 65 years, 67% were males, and 43,5% (n=87) had severe OSA; 85% patients under PAP; 60,4% (n=102) good adherent patients. Overlap with obesity hypoventilation syndrome (n=7) and COPD (n=48) was noti...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Cancela da Fonseca Ferreira Santos, G. S., Van Zeller, M., Carrico, F., Rodrigues, D., Torres Redondo, M., Drummond, M. Tags: 04.02 - Clinical and epidemiological respiratory sleep medicine Source Type: research

Obstructive sleep apnea and other predictors of postoperative complications after bariatric surgery
Conclusions: Prevalence of postoperative complications in bariatric surgery patients was low and untreated moderate to severe OSA was not predictor of prolonged hospital stay.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Aldobyany, A. M., Touman, A., Beshayreh, M., Alamri, F., Ahmed, J., Ghaleb, N., Alsaggaf, R., Alqurashi, H., Albanna, A., Alqurashi, E. Tags: 04.02 - Clinical and epidemiological respiratory sleep medicine Source Type: research

Prevalence of Cardiometabolic Disease in the Greek Sleep Apnea Patients Cohort
Conclusions: We conclude that cardiometabolic disease was very prevalent in our SAP with moderate-severe sleep apnea. Our population consisted mainly of male, obese, middle aged patients. It is of grate interest the high percentage of comorbidities, especially that of arrythmias. Further analysis is needed, in order to identify different phenotypes and the subsequent personalized therapeutic approach.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Trakada, G., Dimitriadis, V., Amfilochiou, A., Siopi, D., Paschidou, V., Alexopoulou, C., Varsou, G., Konstantinidis, A., Steiropoulos, P., Pataka, A., Karachristos, C., Agrafiotis, M., Chasiotou, A., Tselepi, C., Kallianos, A., Fountoulaki, M., Gounidis, Tags: Sleep and control of breathing Source Type: research

Determinants of blood eosinophil count in adults from a large population-based study
Factors not associated with respiratory disease that influence blood eosinophil (B-Eos) count have not been clearly defined. We aimed to evaluate the influence of non-respiratory diseases on B-Eos count and to identify individual characteristics, including gender and body mass index, associated with B-Eos count in individuals without respiratory disease.Individuals (18-85 years) with complete B-Eos data from the US National Health and Nutritional Examination Surveys 2005–2016 were grouped as having respiratory disease (n=7,894) or not having respiratory disease (n=15,010). Among those without respiratory disease, non...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Amaral, R., Jacinto, T., Malinovschi, A., Janson, C., Price, D., Fonseca, J., Alving, K. Tags: Monitoring airway disease Source Type: research

The prevalence and risk factors of obstructive sleep apnea in patients with stroke in a tertiary care hospital in India
Conclusion: OSA is highly prevalent in the stroke population with subtle clinical symptoms. BMI was found to be an independent risk factor associated with moderate to severe OSA. A diagnostic sleep study is warranted in stroke patients, particularly with obesity.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Rajagopal, T. V., Christopher, D. J., Isaac, B., Oliver, A., Mathew, V., Sivadasan, A. Tags: Sleep and control of breathing Source Type: research

Thromboembolic events in COVID-19 patients : A Tunisian case series study
Coronavirus disease 2019 (COVID-19) can lead to systemic coagulation activation and thrombotic complications(TC), which may lead to fatal outcomes if not diagnosed and managed appropriately.We aimed to report the incidence and characteristics of venous and arterial thrombotic complications(TC) in hospitalized patients with COVID-19 and to investigate the predictive factors of their occurrence.A retrospective study including 200 patients with COVID-19 confirmed by a reverse transcription polymerase chain reaction test, admitted between March 2020 and January 2021 in the pulmonary departement B at Abderrahman Mami Hospi...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Louhaichi, S., Ferchichi, M., Khalfallah, I., Belkhir, S., Boubaker, N., Ammar, J., Hamdi, B., Hamzaoui, A. Tags: Respiratory infections and bronchiectasis Source Type: research

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health
There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background. We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients identified using nationwide health registries. We estimated 0.08 (95% CI 0.06–0.11) heritability and identified five loci associated with OSA (p<5.0x10–8): rs4837016 near GAPVD1 (GTPase activating protein and VPS9 domains 1), rs1092856...
Source: European Respiratory Journal - May 6, 2021 Category: Respiratory Medicine Authors: Strausz, S., Ruotsalainen, S., Ollila, H. M., Karjalainen, J., Kiiskinen, T., Reeve, M., Kurki, M., Mars, N., Havulinna, A. S., Luonsi, E., Mansour Aly, D., Ahlqvist, E., Teder-Laving, M., Palta, P., Groop, L., Mägi, R., Mäkitie, A., Salom Tags: Sleep medicine Original Articles: Sleep medicine Source Type: research

Respiratory Sleep Disorders Among 37 Patients With Laryngeal Dysfunction
Conclusion: Sleep disordered breathing (Sleep Apnea Syndrome and hypoventilation) are common in our group of non-obese patients with laryngeal dysfunction. Thyroidectomy was the main etiology, before neurological (Amyotrophic Lateral Sclerosis, post-stroke) and traumatic causes. These results suggest the importance of systematic screening for sleep disordered breathing in this category of patients.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Sedkaoui, K., Mouchon, E., Virginie, W., Crestani, S., Fichaux-Bourin, P., Lescouzeres, M., Didier, A. Tags: Sleep and control of breathing Source Type: research

Conicity index as prognostic factor of major cardiovascular events in obstructive sleep apnea
Conclusions: CI presented a higher association with CVE than BMI. Logistic egression of CVE and CIVariableORCI95p-valueAge1.051.02 - 1.080.001Women0.360.16 - 0.830.016Diabetes2.321.02 - 5.250.045Conicity index3.921.69 - 9.100.001Logistic regression of CVE and CIAge1.071.03 - 1.100.001Women0.420.19 - 0.960.040Diabetes2.281.01 - 5.140.045BMI2.411.09 - 5.320.029
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Lopez-Padilla, D., Teran Tinedo, J. R., Llanos Flores, M., Jimeno, E. R., Ji, Z., Gallo Gonzalez, V., Cerezo Lajas, A., Ojeda Castillejo, E., Lopez Martin, S., Puente Maestu, L. Tags: Sleep and control of breathing Source Type: research

Short term effects of noninvasive ventilation on haemodynamic parameters in patients with obesity hypoventilation syndrome
Conclusion: Acute NIV resulted in reductions of heart rate and improvements in systolic intervals. SV increased after 5 nights with NIV suggesting that NIV is safe in OHS patients with OSA.Support: VEGA 1/0220/17, APPV-16-0158, VEGA 1/0208/16.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Pobeha, P., Paranicova, I., Trojova, I., Tkacova, R., Joppa, P. Tags: Noninvasive ventilatory support Source Type: research

Con: continuous positive airway pressure and cardiovascular prevention
For the last two decades, evidence has been mounting that obstructive sleep apnoea (OSA) may be a cause of cardiovascular disease (CVD). OSA causes repeated acute falls in nocturnal arterial blood oxygen saturation, and rises in blood pressure and heart rate. These physiological changes, combined with the acute mechanical stress placed on the heart from the often very large negative pleural pressure swings during obstructed breathing, were postulated to provide the substrate necessary to induce acute events such as myocardial infarction, arrhythmias, acute heart failure, stroke and sudden cardiovascular death. Observationa...
Source: European Respiratory Journal - May 10, 2018 Category: Respiratory Medicine Authors: McEvoy, R. D., Kohler, M. Tags: Editorials Source Type: research

Chronic bronchitis, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
Conclusions: our preliminary results suggest that 1) chronic respiratory diseases are associated with different cardiovascular risk factors; 2) the associations of CB and rhinitis with cardiovascular diseases seem to be independent of the presence of shared risk factors.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Pesce, G., Marcon, A., Cazzoletti, L., Battaglia, S., Cerveri, I., Pirina, P., Trucco, G., Locatelli, F., Ferrari, M. Tags: Epidemiology Source Type: research

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