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Source: The Lancet Neurology
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Total 249 results found since Jan 2013.
Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial
Publication date: Available online 23 August 2016 Source:The Lancet Neurology Author(s): Kevin N Sheth, Jordan J Elm, Bradley J Molyneaux, Holly Hinson, Lauren A Beslow, Gordon K Sze, Ann-Christin Ostwaldt, Gregory J del Zoppo, J Marc Simard, Sven Jacobson, W Taylor Kimberly Background Preclinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival. We assessed whether intravenous glyburide (RP-1127; glibenclamide) would safely reduce brain swelling, decrease the need for decompressive craniectomy, and improve clinical outcomes in patients presenting with a large hemispheric...
Source: The Lancet Neurology - August 23, 2016 Category: Neurology Source Type: research
Stroke 1-2-0: a rapid response programme for stroke in China
Publication date: Available online 28 October 2016 Source:The Lancet Neurology Author(s): Jing Zhao, Renyu Liu
Source: The Lancet Neurology - October 28, 2016 Category: Neurology Source Type: research
The glymphatic pathway in neurological disorders
Publication date: November 2018Source: The Lancet Neurology, Volume 17, Issue 11Author(s): Martin Kaag Rasmussen, Humberto Mestre, Maiken NedergaardSummaryBackgroundThe glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along arterial perivascular spaces and subsequently into the brain interstitium, facilitated by aquaporin 4 (AQP4) water channels. The pathway then directs flow towards the venous perivascular and perineuronal spaces, ultimately clearing solutes from the neuropil into meningeal and cervical lymphatic...
Source: The Lancet Neurology - October 19, 2018 Category: Neurology Source Type: research
Comparison of eight prehospital stroke scales to detect intracranial large-vessel occlusion in suspected stroke (PRESTO): a prospective observational study
Publication date: Available online 7 January 2021Source: The Lancet NeurologyAuthor(s): Martijne H C Duvekot, Esmee Venema, Anouk D Rozeman, Walid Moudrous, Frédérique H Vermeij, Marileen Biekart, Hester F Lingsma, Lisette Maasland, Annemarie D Wijnhoud, Laus J M M Mulder, Kees C L Alblas, Roeland P J van Eijkelenburg, Bianca I Buijck, Jeannette Bakker, Aarnout S Plaisier, Jan-Hein Hensen, Geert J Lycklama à Nijeholt, Pieter Jan van Doormaal, Adriaan C G M van Es, Aad van der Lugt
Source: The Lancet Neurology - January 8, 2021 Category: Neurology Source Type: research
Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
Publication date: April 2021Source: The Lancet Neurology, Volume 20, Issue 4Author(s): Jonathan G Best, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sanchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker
Source: The Lancet Neurology - March 18, 2021 Category: Neurology Source Type: research
Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts
Publication date: Available online 23 April 2021Source: The Lancet NeurologyAuthor(s): Nick A Weaver, Hugo J Kuijf, Hugo P Aben, Jill Abrigo, Hee-Joon Bae, Mélanie Barbay, Jonathan G Best, Régis Bordet, Francesca M Chappell, Christopher P L H Chen, Thibaut Dondaine, Ruben S van der Giessen, Olivier Godefroy, Bibek Gyanwali, Olivia K L Hamilton, Saima Hilal, Irene M C Huenges Wajer, Yeonwook Kang, L Jaap Kappelle, Beom Joon Kim
Source: The Lancet Neurology - April 24, 2021 Category: Neurology Source Type: research
Chronic kidney disease and stroke
Publication date: November 2014 Source:The Lancet Neurology, Volume 13, Issue 11 Author(s): Cheng-Yang Hsieh , Huey-Juan Lin , Chih-Hung Chen , Edward Chia-Cheng Lai , Yea-Huei Kao Yang
Source: The Lancet Neurology - October 17, 2014 Category: Neurology Source Type: research
Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial
This study is registered with ClinicalTrials.gov, number NCT00349622. Findings Stage 3 included 66 participants from stages 1 and 2 and 448 new participants. In total, 340 participants were randomly allocated to ceftriaxone and 173 to placebo. During stages 1 and 2, mean ALSFRS-R declined more slowly in participants who received 4 g ceftriaxone than in those on placebo (difference 0·51 units per month, 95% CI 0·02 to 1·00; p=0·0416), but in stage 3 functional decline between the treatment groups did not differ (0·09, −0·06 to 0·24; p=0·2370). No significant differences in survival between the groups were recorde...
Source: The Lancet Neurology - October 17, 2014 Category: Neurology Source Type: research
Blood pressure control after stroke: too little, too late, or too soon to tell?
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Argye E Hillis
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Intermittent pneumatic compression after stroke
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Graeme J Hankey
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Neuropsychiatric outcomes after stroke
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Merja E Kallio
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Neuropsychiatric outcomes after stroke – Authors' reply
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Sebastian Köhler , Maree L Hackett , John T O'Brien , Gillian E Mead
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Jane S Paulsen , Jeffrey D Long , Christopher A Ross , Deborah L Harrington , Cheryl J Erwin , Janet K Williams , Holly James Westervelt , Hans J Johnson , Elizabeth H Aylward , Ying Zhang , H Jeremy Bockholt , Roger A Barker Background Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and pr...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Covering all the bases to improve acute stroke care
Publication date: Available online 28 November 2014 Source:The Lancet Neurology Author(s): Steven R Levine
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Stroke: an emphasis on guidelines
Publication date: January 2015 Source:The Lancet Neurology, Volume 14, Issue 1 Author(s): Philip B Gorelick , Muhammad U Farooq
Source: The Lancet Neurology - December 9, 2014 Category: Neurology Source Type: research
