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Source: The Lancet Neurology
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Total 249 results found since Jan 2013.
Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial
Publication date: Available online 23 August 2016 Source:The Lancet Neurology Author(s): Serge Bracard, Xavier Ducrocq, Jean Louis Mas, Marc Soudant, Catherine Oppenheim, Thierry Moulin, Francis Guillemin Background Intravenous thrombolysis with alteplase alone cannot reperfuse most large-artery strokes. We aimed to determine whether mechanical thrombectomy in addition to intravenous thrombolysis improves clinical outcome in patients with acute ischaemic stroke. Methods THRACE is a randomised controlled trial done in 26 centres in France. Patients aged 18–80 years with acute ischaemic stroke and proximal cerebral artery...
Source: The Lancet Neurology - August 23, 2016 Category: Neurology Source Type: research
Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
Publication date: Available online 6 November 2018Source: The Lancet NeurologyAuthor(s): Bruce C V Campbell, Charles B L M Majoie, Gregory W Albers, Bijoy K Menon, Nawaf Yassi, Gagan Sharma, Wim H van Zwam, Robert J van Oostenbrugge, Andrew M Demchuk, Francis Guillemin, Philip White, Antoni Dávalos, Aad van der Lugt, Kenneth S Butcher, Aboubaker Cherifi, Henk A Marquering, Geoffrey Cloud, Juan M Macho Fernández, Jeremy Madigan, Catherine OppenheimSummaryBackgroundCT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aimed to establish whether imaging assessment...
Source: The Lancet Neurology - November 7, 2018 Category: Neurology Source Type: research
Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial
This study is registered with ClinicalTrials.gov, number NCT01313299. Findings 243 patients were randomly allocated to placebo (n=81), abobotulinumtoxinA 500 U (n=81), or abobotulinumtoxinA 1000 U (n=81). Mean change in MAS score from baseline at week 4 in the PTMG was −0·3 (SD 0·6) in the placebo group (n=79), −1·2 (1·0) in the abobotulinumtoxinA 500 U group (n=80; difference −0·9, 95% CI −1·2 to −0·6; p<0·0001 vs placebo), and −1·4 (1·1) in the abobotulinumtoxinA 1000 U group (n=79; −1·1, −1·4 to −0·8; p<0·0001 vs placebo). Mean PGA score at week 4 was 0·6 (SD 1·0) in the ...
Source: The Lancet Neurology - August 27, 2015 Category: Neurology Source Type: research
Optimal stroke prevention in patients with PFO
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Maurizio Melis, Stefano Ricci, Danilo Toni, editorial committee of the Italian National Guidelines on Stroke
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Publication date: Available online 22 May 2019Source: The Lancet NeurologyAuthor(s): Rustam Al-Shahi Salman, David P Minks, Dipayan Mitra, Mark A Rodrigues, Priya Bhatnagar, Johann C du Plessis, Yogish Joshi, Martin S Dennis, Gordon D Murray, David E Newby, Peter A G Sandercock, Nikola Sprigg, Jacqueline Stephen, Cathie L M Sudlow, David J Werring, William N Whiteley, Joanna M Wardlaw, Philip M White, Colin Baigent, Daniel LassersonSummaryBackgroundFindings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antipl...
Source: The Lancet Neurology - May 23, 2019 Category: Neurology Source Type: research
Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial
Publication date: Available online 12 February 2015 Source:The Lancet Neurology Background Extracranial carotid and vertebral artery dissection is an important cause of stroke, especially in young people. In some observational studies it has been associated with a high risk of recurrent stroke. Both antiplatelet drugs and anticoagulant drugs are used to reduce risk of stroke but whether one treatment strategy is more effective than the other is unknown. We compared their efficacy in the Cervical Artery Dissection in Stroke Study (CADISS), with the additional aim of establishing the true risk of recurrent stroke. Methods W...
Source: The Lancet Neurology - February 13, 2015 Category: Neurology Source Type: research
Stenting versus medical treatment in patients with symptomatic vertebral artery stenosis: a randomised open-label phase 2 trial
Publication date: Available online 20 April 2015 Source:The Lancet Neurology Author(s): Annette Compter , H Bart van der Worp , Wouter J Schonewille , Jan Albert Vos , Jelis Boiten , Paul J Nederkoorn , Maarten Uyttenboogaart , Rob T Lo , Ale Algra , L Jaap Kappelle Background Patients with a recent vertebrobasilar transient ischaemic attack or ischaemic stroke and vertebral artery stenosis of at least 50% have a high risk of future vertebrobasilar stroke. Stenting of vertebral artery stenosis is promising, but of uncertain benefit. We investigated the safety and feasibility of stenting of symptomatic vertebral artery st...
Source: The Lancet Neurology - April 21, 2015 Category: Neurology Source Type: research
Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient data
Publication date: Available online 6 February 2019Source: The Lancet NeurologyAuthor(s): Thomas G Brott, David Calvet, George Howard, John Gregson, Ale Algra, Jean-Pierre Becquemin, Gert J de Borst, Richard Bulbulia, Hans-Henning Eckstein, Gustav Fraedrich, Jacoba P Greving, Alison Halliday, Jeroen Hendrikse, Olav Jansen, Jenifer H Voeks, Peter A Ringleb, Jean-Louis Mas, Martin M Brown, Leo H Bonati, Carotid Stenosis Trialists' CollaborationSummaryBackgroundThe risk of periprocedural stroke or death is higher after carotid artery stenting (CAS) than carotid endarterectomy (CEA) for the treatment of symptomatic carotid sten...
Source: The Lancet Neurology - February 7, 2019 Category: Neurology Source Type: research
Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis
Publication date: Available online 23 May 2019Source: The Lancet NeurologyAuthor(s): Hugh S Markus, Eric L Harshfield, Annette Compter, Wilhelm Kuker, L Jaap Kappelle, Andrew Clifton, H Bart van der Worp, Peter Rothwell, Ale Algra, Neil Baldwin, Marcus Bradley, Stefan Brew, Robert Crossley, Anand Dixit, Hedley Emsley, Ian Ford, Peter Gaines, Anil Gholkhar, Anthony Goddard, Timothy HamptonSummaryBackgroundSymptomatic vertebral artery stenosis is associated with a high risk of recurrent stroke, with higher risks for intracranial than for extracranial stenosis. Vertebral artery stenosis can be treated with stenting with good ...
Source: The Lancet Neurology - May 25, 2019 Category: Neurology Source Type: research
Global, regional, and national burden of neurological disorders during 1990 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Publication date: Available online 17 September 2017 Source:The Lancet Neurology Author(s): GBD 2015 Neurological Disorders Collaborator GroupValery LFeiginAmanuel AlemuAbajobirKalkidan HassenAbateFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaGebre YitayihAbyuMuktar BeshirAhmedAmani NidhalAichourIbtihelAichourMiloud Taki EddineAichourRufus OlusolaAkinyemiSamerAlabedRajaaAl-RaddadiNelsonAlvis-GuzmanAzmeraw T.AmareHosseinAnsariPalwashaAnwariJohanÄrnlövHamidAsayeshSolomon WeldegebrealAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripideFrinelG. ArthurAvokpahoAleksandraBaracMiguelBarbozaSuzanne LBarker-ColloTillBärnighaus...
Source: The Lancet Neurology - September 19, 2017 Category: Neurology Source Type: research
Stroke–heart syndrome: clinical presentation and underlying mechanisms
Publication date: Available online 26 October 2018Source: The Lancet NeurologyAuthor(s): Jan F Scheitz, Christian H Nolte, Wolfram Doehner, Vladimir Hachinski, Matthias EndresSummaryCardiac complications are a frequent medical problem during the first few days after an ischaemic stroke, and patients present with a broad range of symptoms including myocardial injury, cardiac dysfunction, and arrhythmia, with varying overlap between these three conditions. Evidence from clinical and neuroimaging studies and animal research suggests that these cardiac disturbances share the same underlying mechanisms. Although the exact casca...
Source: The Lancet Neurology - October 27, 2018 Category: Neurology Source Type: research
Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Publication date: Available online 14 March 2019Source: The Lancet NeurologyAuthor(s): Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-VenningSummaryBackgroundNeurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Inj...
Source: The Lancet Neurology - March 16, 2019 Category: Neurology Source Type: research
Migraine pathophysiology: lessons from mouse models and human genetics
Publication date: January 2015 Source:The Lancet Neurology, Volume 14, Issue 1 Author(s): Michel D Ferrari , Roselin R Klever , Gisela M Terwindt , Cenk Ayata , Arn M J M van den Maagdenberg Summary Migraine is a common, disabling, and undertreated episodic brain disorder that is more common in women than in men. Unbiased genome-wide association studies have identified 13 migraine-associated variants pointing at genes that cluster in pathways for glutamatergic neurotransmission, synaptic function, pain sensing, metalloproteinases, and the vasculature. The individual pathogenetic contribution of each gene variant is diffi...
Source: The Lancet Neurology - December 9, 2014 Category: Neurology Source Type: research
Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection
Publication date: June 2015 Source:The Lancet Neurology, Volume 14, Issue 6 Author(s): Stéphanie Debette , Annette Compter , Marc-Antoine Labeyrie , Maarten Uyttenboogaart , Tina M Metso , Jennifer J Majersik , Barbara Goeggel-Simonetti , Stefan T Engelter , Alessandro Pezzini , Philippe Bijlenga , Andrew M Southerland , Olivier Naggara , Yannick Béjot , John W Cole , Anne Ducros , Giacomo Giacalone , Sabrina Schilling , Peggy Reiner , Hakan Sarikaya , Janna C Welleweerd , L Jaap Kappelle , Gert Jan de Borst , Leo H Bonati , Simon Jung , Vincent Thijs , Juan J Martin , Tobias Brandt , Caspar Grond-Ginsbach , Manja Klos...
Source: The Lancet Neurology - May 11, 2015 Category: Neurology Source Type: research
Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial
Publication date: May 2016 Source:The Lancet Neurology, Volume 15, Issue 6 Author(s): Thorsten Steiner, Sven Poli, Martin Griebe, Johannes Hüsing, Jacek Hajda, Anja Freiberger, Martin Bendszus, Julian Bösel, Hanne Christensen, Christian Dohmen, Michael Hennerici, Jennifer Kollmer, Henning Stetefeld, Katja E Wartenberg, Christian Weimar, Werner Hacke, Roland Veltkamp Background Haematoma expansion is a major cause of mortality in intracranial haemorrhage related to vitamin K antagonists (VKA-ICH). Normalisation of the international normalised ratio (INR) is recommended, but optimum haemostatic managemen...
Source: The Lancet Neurology - April 19, 2016 Category: Neurology Source Type: research
