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Source: The Lancet Neurology
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Total 104 results found since Jan 2013.
Risks of recurrent stroke and all serious vascular events after spontaneous intracerebral haemorrhage: pooled analyses of two population-based studies
Publication date: June 2021Source: The Lancet Neurology, Volume 20, Issue 6Author(s): Linxin Li, Michael T C Poon, Neshika E Samarasekera, Luke A Perry, Tom J Moullaali, Mark A Rodrigues, James J M Loan, Jacqueline Stephen, Christine Lerpiniere, Maria A Tuna, Sergei A Gutnikov, Wilhelm Kuker, Louise E Silver, Rustam Al-Shahi Salman, Peter M Rothwell
Source: The Lancet Neurology - May 20, 2021 Category: Neurology Source Type: research
Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study
Publication date: June 2021Source: The Lancet Neurology, Volume 20, Issue 6Author(s): Karl Georg Haeusler, Paulus Kirchhof, Claudia Kunze, Serdar Tütüncü, Cornelia Fiessler, Carolin Malsch, Manuel C Olma, Muhammad Jawad-Ul-Qamar, Michael Krämer, Rolf Wachter, Dominik Michalski, Andrea Kraft, Timolaos Rizos, Klaus Gröschel, Götz Thomalla, Darius G Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U Heuschmann
Source: The Lancet Neurology - May 20, 2021 Category: Neurology Source Type: research
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
Publication date: Available online 25 March 2021Source: The Lancet NeurologyAuthor(s): Matthew Traylor, Elodie Persyn, Liisa Tomppo, Sofia Klasson, Vida Abedi, Mark K Bakker, Nuria Torres, Linxin Li, Steven Bell, Loes Rutten-Jacobs, Daniel J Tozer, Christoph J Griessenauer, Yanfei Zhang, Annie Pedersen, Pankaj Sharma, Jordi Jimenez-Conde, Tatjana Rundek, Raji P Grewal, Arne Lindgren, James F Meschia
Source: The Lancet Neurology - March 27, 2021 Category: Neurology Source Type: research
Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
Publication date: April 2021Source: The Lancet Neurology, Volume 20, Issue 4Author(s): Jonathan G Best, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sanchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker
Source: The Lancet Neurology - March 18, 2021 Category: Neurology Source Type: research
Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis
Publication date: March 2021Source: The Lancet Neurology, Volume 20, Issue 3Author(s): Dominic P J Howard, Liam Gaziano, Peter M Rothwell, Oxford Vascular Study
Source: The Lancet Neurology - February 18, 2021 Category: Neurology Source Type: research
Comparison of eight prehospital stroke scales to detect intracranial large-vessel occlusion in suspected stroke (PRESTO): a prospective observational study
Publication date: Available online 7 January 2021Source: The Lancet NeurologyAuthor(s): Martijne H C Duvekot, Esmee Venema, Anouk D Rozeman, Walid Moudrous, Frédérique H Vermeij, Marileen Biekart, Hester F Lingsma, Lisette Maasland, Annemarie D Wijnhoud, Laus J M M Mulder, Kees C L Alblas, Roeland P J van Eijkelenburg, Bianca I Buijck, Jeannette Bakker, Aarnout S Plaisier, Jan-Hein Hensen, Geert J Lycklama à Nijeholt, Pieter Jan van Doormaal, Adriaan C G M van Es, Aad van der Lugt
Source: The Lancet Neurology - January 8, 2021 Category: Neurology Source Type: research
Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study
Publication date: May 2020Source: The Lancet Neurology, Volume 19, Issue 5Author(s): Robert Hurford, Frank J Wolters, Linxin Li, Kui Kai Lau, Wilhelm Küker, Peter M Rothwell, Oxford Vascular Study Phenotyped Cohort
Source: The Lancet Neurology - April 24, 2020 Category: Neurology Source Type: research
Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitabi...
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research
Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial
In this study, we aimed to investigate the safety and efficacy of endovascular treatment of acute strokes due to vertebrobasilar artery occlusion.MethodsWe did a multicentre, randomised, open-label trial, with blinded outcome assessment of thrombectomy in patients presenting within 8 h of vertebrobasilar occlusion at 28 centres in China. Patients were randomly assigned (1:1) to endovascular therapy plus standard medical therapy (intervention group) or standard medical therapy alone (control group). The randomisation sequence was computer-generated and stratified by participating centres. Allocation concealment was implemen...
Source: The Lancet Neurology - December 10, 2019 Category: Neurology Source Type: research
The gut microbiome in neurological disorders
Publication date: Available online 18 November 2019Source: The Lancet NeurologyAuthor(s): John F Cryan, Kenneth J O'Riordan, Kiran Sandhu, Veronica Peterson, Timothy G DinanSummaryResearch into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical evidence implicates the microbiome as a possible key susceptibility factor for neurological disorders, including Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease, and stroke. Cross-sectional clinical studies are bolstering ...
Source: The Lancet Neurology - November 19, 2019 Category: Neurology Source Type: research
A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial
Publication date: Available online 7 November 2019Source: The Lancet NeurologyAuthor(s): Michael Ahmadi, Inga Laumeier, Thomas Ihl, Maureen Steinicke, Caroline Ferse, Matthias Endres, Armin Grau, Sidsel Hastrup, Holger Poppert, Frederick Palm, Martin Schoene, Christian L Seifert, Farid I Kandil, Joachim E Weber, Paul von Weitzel-Mudersbach, Martin L J Wimmer, Ale Algra, Pierre Amarenco, Jacoba P Greving, Otto BusseSummaryBackgroundPatients with recent stroke or transient ischaemic attack are at high risk for a further vascular event, possibly leading to permanent disability or death. Although evidence-based treatments for ...
Source: The Lancet Neurology - November 8, 2019 Category: Neurology Source Type: research
Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study
This study is registered with ClinicalTrials.gov, number NCT02119182.FindingsBetween Feb 26, 2014, and June 15, 2018, we recruited 450 patients with normal head CT scans (of whom 330 had negative MRI scans and 120 had positive MRI scans), 122 orthopaedic trauma controls, and 209 healthy controls. AUC for GFAP in patients with CT-negative and MRI-positive findings versus patients with CT-negative and MRI-negative findings was 0·777 (95% CI 0·726–0·829) over 24 h. Median plasma GFAP concentration was highest in patients with CT-negative and MRI-positive findings (414·4 pg/mL, 25–75th percentile 139·3–813·4), foll...
Source: The Lancet Neurology - August 24, 2019 Category: Neurology Source Type: research
Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS): a multicentre, single-blinded, randomised controlled trial
Publication date: September 2019Source: The Lancet Neurology, Volume 18, Issue 9Author(s): Rebecca Palmer, Munyaradzi Dimairo, Cindy Cooper, Pam Enderby, Marian Brady, Audrey Bowen, Nicholas Latimer, Steven Julious, Elizabeth Cross, Abualbishr Alshreef, Madeleine Harrison, Ellen Bradley, Helen Witts, Tim ChaterSummaryBackgroundPost-stroke aphasia might improve over many years with speech and language therapy; however speech and language therapy is often less readily available beyond a few months after stroke. We assessed self-managed computerised speech and language therapy (CSLT) as a means of providing more therapy than ...
Source: The Lancet Neurology - August 8, 2019 Category: Neurology Source Type: research
Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations: a population-based cohort study, systematic review, and meta-analysis
Publication date: Available online 7 August 2019Source: The Lancet NeurologyAuthor(s): Susanna M Zuurbier, Charlotte R Hickman, Christos S Tolias, Leon A Rinkel, Rebecca Leyrer, Kelly D Flemming, David Bervini, Giuseppe Lanzino, Robert J Wityk, Hans-Martin Schneble, Ulrich Sure, Rustam Al-Shahi Salman, Scottish Audit of Intracranial Vascular Malformations Steering CommitteeSummaryBackgroundAntithrombotic (anticoagulant or antiplatelet) therapy is withheld from some patients with cerebral cavernous malformations, because of uncertainty around the safety of these drugs in such patients. We aimed to establish whether antithro...
Source: The Lancet Neurology - August 8, 2019 Category: Neurology Source Type: research
Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis
Publication date: Available online 23 May 2019Source: The Lancet NeurologyAuthor(s): Hugh S Markus, Eric L Harshfield, Annette Compter, Wilhelm Kuker, L Jaap Kappelle, Andrew Clifton, H Bart van der Worp, Peter Rothwell, Ale Algra, Neil Baldwin, Marcus Bradley, Stefan Brew, Robert Crossley, Anand Dixit, Hedley Emsley, Ian Ford, Peter Gaines, Anil Gholkhar, Anthony Goddard, Timothy HamptonSummaryBackgroundSymptomatic vertebral artery stenosis is associated with a high risk of recurrent stroke, with higher risks for intracranial than for extracranial stenosis. Vertebral artery stenosis can be treated with stenting with good ...
Source: The Lancet Neurology - May 25, 2019 Category: Neurology Source Type: research
