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Source: The Lancet

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Total 200 results found since Jan 2013.

Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis
Publication date: Available online 24 October 2019Source: The LancetAuthor(s): Marc A Suchard, Martijn J Schuemie, Harlan M Krumholz, Seng Chan You, RuiJun Chen, Nicole Pratt, Christian G Reich, Jon Duke, David Madigan, George Hripcsak, Patrick B RyanSummaryBackgroundUncertainty remains about the optimal monotherapy for hypertension, with current guidelines recommending any primary agent among the first-line drug classes thiazide or thiazide-like diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, dihydropyridine calcium channel blockers, and non-dihydropyridine calcium channel blockers, in ...
Source: The Lancet - October 26, 2019 Category: General Medicine Source Type: research

Adverse outcomes after total and unicompartmental knee replacement in 101 330 matched patients: a study of data from the National Joint Registry for England and Wales
Publication date: 18–24 October 2014 Source:The Lancet, Volume 384, Issue 9952 Author(s): Alexander D Liddle , Andrew Judge , Hemant Pandit , David W Murray Background Total knee replacement (TKR) or unicompartmental knee replacement (UKR) are options for end-stage osteoarthritis. However, comparisons between the two procedures are confounded by differences in baseline characteristics of patients undergoing either procedure and by insufficient reporting of endpoints other than revision. We aimed to compare adverse outcomes for each procedure in matched patients. Methods With propensity score techniques, we compared ma...
Source: The Lancet - October 17, 2014 Category: Journals (General) Source Type: research

Alteplase in acute ischaemic stroke: the need for speed
Publication date: 29 November–5 December 2014 Source:The Lancet, Volume 384, Issue 9958 Author(s): Michael D Hill , Shelagh B Coutts
Source: The Lancet - December 4, 2014 Category: Journals (General) Source Type: research

Preventive antibiotic therapy in stroke: PASSed away?
Publication date: Available online 20 January 2015 Source:The Lancet Author(s): Andreas Meisel
Source: The Lancet - January 21, 2015 Category: Journals (General) Source Type: research

The burden of disease in older people and implications for health policy and practice
Publication date: 7–13 February 2015 Source:The Lancet, Volume 385, Issue 9967 Author(s): Martin J Prince , Fan Wu , Yanfei Guo , Luis M Gutierrez Robledo , Martin O'Donnell , Richard Sullivan , Salim Yusuf 23% of the total global burden of disease is attributable to disorders in people aged 60 years and older. Although the proportion of the burden arising from older people (≥60 years) is highest in high-income regions, disability-adjusted life years (DALYs) per head are 40% higher in low-income and middle-income regions, accounted for by the increased burden per head of population arising from cardiovascular disease...
Source: The Lancet - February 10, 2015 Category: Journals (General) Source Type: research

Blood pressure in acute stroke: which questions remain?
Publication date: 14–20 February 2015 Source:The Lancet, Volume 385, Issue 9968 Author(s): Peter M Rothwell
Source: The Lancet - February 13, 2015 Category: Journals (General) Source Type: research

Cardioverter defibrillator implantation without induction of ventricular fibrillation: a single-blind, non-inferiority, randomised controlled trial (SIMPLE)
We examined safety with two, 30 day, adverse event outcome clusters. The trial is registered with ClinicalTrials.gov, number NCT00800384. Findings Between Jan 13, 2009, and April 4, 2011, of 2500 eligible patients, 1253 were randomly assigned to defibrillation testing and 1247 to no-testing, and followed up for a mean of 3·1 years (SD 1·0). The primary outcome of arrhythmic death or failed appropriate shock occurred in fewer patients (90 [7% per year]) in the no-testing group than patients who did receive it (104 [8% per year]; HR 0·86, 95% CI 0·65–1·14; pnon-inferiority <0·0001). The first safety composite...
Source: The Lancet - February 23, 2015 Category: Journals (General) Source Type: research

Effects of blood pressure lowering on cardiovascular risk according to baseline body-mass index: a meta-analysis of randomised trials
Publication date: 7–13 March 2015 Source:The Lancet, Volume 385, Issue 9971 Background The cardiovascular benefits of blood pressure lowering in obese people compared with people of normal weight might depend on choice of drug. We compared the effects of blood pressure-lowering regimens on cardiovascular risk in groups of patients categorised by baseline body-mass index (BMI). Methods We used individual patient data from trials included in the Blood Pressure Lowering Treatment Trialists' Collaboration to compare the effects of different classes of blood pressure-lowering regimens for the primary outcome of total major c...
Source: The Lancet - March 6, 2015 Category: Journals (General) Source Type: research

Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
This study is registered with ClinicalTrials.gov, number NCT00968708. Findings 5380 patients were assigned to alogliptin (n=2701) or placebo (n=2679) and followed up for a median of 533 days (IQR 280–751). The exploratory extended MACE endpoint was seen in 433 (16·0%) patients assigned to alogliptin and in 441 (16·5%) assigned to placebo (hazard ratio [HR] 0·98, 95% CI 0·86–1·12). Hospital admission for heart failure was the first event in 85 (3·1%) patients taking alogliptin compared with 79 (2·9%) taking placebo (HR 1·07, 95% CI 0·79–1·46). Alogliptin had no effect on composite events of cardiovascular d...
Source: The Lancet - March 12, 2015 Category: Journals (General) Source Type: research

Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial
Publication date: Available online 16 March 2015 Source:The Lancet Author(s): Marco Valgimigli , Andrea Gagnor , Paolo Calabró , Enrico Frigoli , Sergio Leonardi , Tiziana Zaro , Paolo Rubartelli , Carlo Briguori , Giuseppe Andò , Alessandra Repetto , Ugo Limbruno , Bernardo Cortese , Paolo Sganzerla , Alessandro Lupi , Mario Galli , Salvatore Colangelo , Salvatore Ierna , Arturo Ausiello , Patrizia Presbitero , Gennaro Sardella , Ferdinando Varbella , Giovanni Esposito , Andrea Santarelli , Simone Tresoldi , Marco Nazzaro , Antonio Zingarelli , Nicoletta de Cesare , Stefano Rigattieri , Paolo Tosi , Cataldo Palmieri ,...
Source: The Lancet - March 17, 2015 Category: Journals (General) Source Type: research

Reversible right heart failure after medullary stroke
Publication date: 4–10 April 2015 Source:The Lancet, Volume 385, Issue 9975 Author(s): Han-Gil Jeong , Dae Lim Koo , Hyunwoo Nam , Hyung-Min Kwon
Source: The Lancet - April 3, 2015 Category: Journals (General) Source Type: research

Thrombolysis for stroke: clinical judgment at its apogee
Publication date: 11–17 April 2015 Source:The Lancet, Volume 385, Issue 9976 Author(s): The Lancet
Source: The Lancet - April 10, 2015 Category: Journals (General) Source Type: research

Thrombolysis in acute stroke
Publication date: 11–17 April 2015 Source:The Lancet, Volume 385, Issue 9976 Author(s): Peter Appelros , Andreas Terént
Source: The Lancet - April 10, 2015 Category: Journals (General) Source Type: research

Thrombolysis in acute stroke – Authors' reply
Publication date: 11–17 April 2015 Source:The Lancet, Volume 385, Issue 9976 Author(s): Jonathan Emberson , Kennedy R Lees , Patrick Lyden , Colin Baigent , Peter Sandercock , Werner Hacke
Source: The Lancet - April 10, 2015 Category: Journals (General) Source Type: research

AVERT: a major milestone in stroke research
Publication date: Available online 10 May 2015 Source:The Lancet Author(s): Peter M Rothwell
Source: The Lancet - May 11, 2015 Category: Journals (General) Source Type: research