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Sensorimotor Connectivity after Motor Exercise with Neurofeedback in Post-Stroke Patients with Hemiplegia
This study showed neurophysiological evidence that EEG-contingent neurofeedback is a promising strategy to induce intrinsic ipsilesional sensorimotor reorganization, supporting the importance of integrating closed-loop sensorimotor processing at a neurophysiological level.
Source: Neuroscience - July 28, 2019 Category: Neuroscience Source Type: research

Stroke longitudinal volumetric measures correlate with the behavioral score in non-human primates
Publication date: Available online 24 November 2018Source: NeuroscienceAuthor(s): Gabriel Ramirez-Garcia, Kathleen A. Harrison, Juan Fernandez-Ruiz, Joseph Y. Nashed, Douglas J. CookAbstractStroke is the second leading cause of death worldwide. Brain imaging data from experimental rodent stroke models suggest that size and location of the ischemic lesion relate to behavioral outcome. However, such a relationship between these two variables has not been established in Non-Human Primate (NHP) models. Thus, we aimed to evaluate whether size, location, and severity of stroke following controlled Middle Cerebral Artery Occlusio...
Source: Neuroscience - November 25, 2018 Category: Neuroscience Source Type: research

Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities
Publication date: 10 August 2018Source: Neuroscience, Volume 385Author(s): Qianping Luo, Yong Fan, Lili Lin, Jingjing Wei, Zuanfang Li, Yongkun Li, Susumu Nakae, Wei Lin, Qi ChenAbstractInterleukin-33 (IL-33), a novel member of the IL-1 family, expressed in many tissue and cell types, is involved in inflammation and immune functions. Previous studies suggest that IL-33 may play a role in ischemic stroke. Here, we evaluated the effect of IL-33 in cerebral ischemia–reperfusion-induced injury and investigated its underlying mechanism. Our data indicated that IL-33 deficiency exacerbated the neurological dysfunction caused b...
Source: Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research

Group comparison of cortical fiber connectivity map: An application between post-stroke patients and healthy subjects
This study demonstrated the feasibility of vertex-wise group comparison for evaluating cortical fiber connectivity density. The FiCD method has good intra- and inter-individual reproducibility, and accurately reflects the affected cortical regions in post-stroke patients. This method may be helpful for neuroscience research.
Source: Neuroscience - January 11, 2017 Category: Neuroscience Source Type: research

Increased functional connectivity one week after motor learning and tDCS in stroke patients
Publication date: 6 January 2017 Source:Neuroscience, Volume 340 Author(s): Stéphanie Lefebvre, Laurence Dricot, Patrice Laloux, Philippe Desfontaines, Frédéric Evrard, André Peeters, Jacques Jamart, Yves Vandermeeren Recent studies using resting-state functional magnetic resonance imaging (rs-fMRI) demonstrated that changes in functional connectivity (FC) after stroke correlate with recovery. The aim of this study was to explore whether combining motor learning to dual transcranial direct current stimulation (dual-tDCS, applied over both primary motor cortices (M1)) modulated FC in stroke patients. Twenty-two chronic...
Source: Neuroscience - November 25, 2016 Category: Neuroscience Source Type: research

Impaired implicit learning and feedback processing after stroke
Publication date: 9 February 2016 Source:Neuroscience, Volume 314 Author(s): J.M. Lam, C. Globas, J.A. Hosp, H.-O. Karnath, T. Wächter, A.R. Luft The ability to learn is assumed to support successful recovery and rehabilitation therapy after stroke. Hence, learning impairments may reduce the recovery potential. Here, the hypothesis is tested that stroke survivors have deficits in feedback-driven implicit learning. Stroke survivors (n =30) and healthy age-matched control subjects (n =21) learned a probabilistic classification task with brain activation measured using functional magnetic resonance imaging in a subse...
Source: Neuroscience - December 18, 2015 Category: Neuroscience Source Type: research

In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke
Conclusions: We conclude that the combined approach of USPIO-MRI and [11C]PK11195-PET allows to observe post-stroke inflammatory processes in the living animal in an intraindividual and longitudinal fashion, predicting long-term tissue fate. The non-invasive imaging methods do not affect the immune system and have been applied to human subjects before. Translation into clinical applications is therefore feasible. Graphical abstract
Source: Neuroscience - March 11, 2015 Category: Neuroscience Source Type: research

Internal capsule stroke in the common marmoset
Publication date: 22 January 2015 Source:Neuroscience, Volume 284 Author(s): S. Puentes , T. Kaido , T. Hanakawa , N. Ichinohe , T. Otsuki , K. Seki White matter (WM) impairment and motor deficit after stroke are directly related. However, WM injury mechanisms and their relation to motor disturbances are still poorly understood. In humans, the anterior choroidal artery (AChA) irrigates the internal capsule (IC), and stroke to this region can induce isolated motor impairment. The goal of this study was to analyze whether AChA occlusion can injure the IC in the marmoset monkey. The vascular distribution of the marmoset bra...
Source: Neuroscience - November 20, 2014 Category: Neuroscience Source Type: research