• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Matrix Metalloproteinase-9 Expression is Enhanced by Ischemia and Tissue Plasminogen Activator and Induces Hemorrhage, Disability and Mortality in Experimental Stroke
Publication date: Available online 17 January 2021Source: NeuroscienceAuthor(s): Sofiyan Saleem, Dong Wang, Tieqiang Zhao, Ryan D. Sullivan, Guy L. Reed
Source: Neuroscience - January 18, 2021 Category: Neuroscience Source Type: research

Astragaloside IV Protects Primary Cerebral Cortical Neurons from Oxygen and Glucose Deprivation/Reoxygenation by Activating the PKA/CREB Pathway
Publication date: Available online 30 January 2019Source: NeuroscienceAuthor(s): Bingjie Xue, Jisheng Huang, Bo Ma, Bin Yang, Dennis Chang, Jianxun LiuAbstractStroke is one of the major leading causes of death and disability worldwide, and post-stroke cognitive impairment is a major contributor to this disability. Astragaloside IV (AST-IV) is a primary bioactive compound of Radix Astragali, which is widely used in traditional Chinese medicine to treat stroke. AST-IV was found to possess cognition-enhancing properties against ischemic stroke; however, the mechanisms underlying this effect remain largely elusive. Mitochondri...
Source: Neuroscience - January 30, 2019 Category: Neuroscience Source Type: research

MiRNA-27b regulates angiogenesis by targeting AMPK in mouse ischemic stroke model
Publication date: Available online 2 December 2018Source: NeuroscienceAuthor(s): Yimei Yuan, Zhaoguang Zhang, ZhenGang Wang, Liu JinlanAbstractStroke is a leading cause of mortality and serious disability worldwide with limited treatment options. Angiogenesis has been reported to involved in post-stroke recovery. Although the molecular mechanisms that regulate angiogenesis remain ambiguous, microRNAs have emerged as effective regulators of angiogenesis, involved in neurological function outcome. The present study aims to investigate the regulatory effects of miRNA-27b on post-stroke angiogenesis. In primary cultured brain ...
Source: Neuroscience - December 2, 2018 Category: Neuroscience Source Type: research

Neuroprotective Effect of Sirt2-specific Inhibitor AK-7 Against Acute Cerebral Ischemia is P38 Activation-dependent in Mice
In this study, we found that P38 was specifically activated after focal cerebral ischemic injury, and it was also significantly activated after AK-7 administration in a concentration-dependent manner in vitro and in vivo. AK-7 decreased the infarction volume remarkably and promoted the recovery of neurological function efficiently in the mice evaluated by behavior tests. In contrast, pP38 inhibition increased the infarct volume and exacerbated the symptoms of paralysis. Herein, we suggest AK-7 improves the outcome of brain ischemia in dependence on the P38 activation in mice, which may serve as a strategy for the treatment of stroke.
Source: Neuroscience - February 9, 2018 Category: Neuroscience Source Type: research

Post-stroke treatment with 17 β-estradiol exerts neuroprotective effects in both normotensive and hypertensive rats
Publication date: 21 April 2017 Source:Neuroscience, Volume 348 Author(s): Wendy Stoop, Deborah De Geyter, Sofie Verachtert, Sofie Brouwers, Peggy Verdood, Jacques De Keyser, Ron Kooijman Although ischemic stroke is a major cause of death worldwide and the predominant cause of acquired disability, the only effective drug therapy that has been developed thus far is reperfusion by tissue plasminogen activator. Since most patients do not qualify for this treatment, new methods have to be developed. It is well known that estradiol (E2) exerts neuroprotective effects in different models of cerebral ischemia, but post-stroke tr...
Source: Neuroscience - March 15, 2017 Category: Neuroscience Source Type: research