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Source: Neuroscience
Condition: Stroke
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Total 160 results found since Jan 2013.
Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression
Publication date: 23 June 2017 Source:Neuroscience, Volume 354 Author(s): Zhijun Li, Jing Li, Na Tang Brain microvascular endothelial cell (BMEC) injury induced by ischemia–reperfusion (I/R) is the initial stage of blood–brain barrier (BBB) disruption, which results in a poor prognosis in ischemic stroke patients. Autophagy has been shown to have protective effects on BMECs against cerebral ischemic insults. However, molecular mechanism of BMEC autophagy during I/R is unclear. Long noncoding RNAs (lncRNAs) are emerging as new factors involved in cell autophagy. LncRNA Malat1 is one of the most highly upregulated I/R o...
Source: Neuroscience - May 8, 2017 Category: Neuroscience Source Type: research
Electroencephalographic sensorimotor rhythms are modulated in the acute phase following focal vibration in healthy subjects
Publication date: 3 June 2017 Source:Neuroscience, Volume 352 Author(s): Susanna Lopez, Fabiano Bini, Claudio Del Percio, Franco Marinozzi, Claudia Celletti, Antonio Suppa, Raffaele Ferri, Emanuela Staltari, Filippo Camerota, Claudio Babiloni Few minutes of focal vibration (FV) on limb muscles can improve motor control in neurological (stroke, Parkinson) patients for unknown underlying neurophysiological mechanisms. Here we hypothesized that in healthy volunteers this FV would increase excitability in the primary sensorimotor cortex (S1-M1) during an isometric contraction of the stimulated muscle. The design included an i...
Source: Neuroscience - April 26, 2017 Category: Neuroscience Source Type: research
Administration of sonic hedgehog protein induces angiogenesis and has therapeutic effects after stroke in rats
Publication date: 3 June 2017 Source:Neuroscience, Volume 352 Author(s): Sheng-cai Chen, Ming Huang, Quan-wei He, Yan Zhang, Elvis Nana Opoku, Hang Yang, Hui-juan Jin, Yuan-peng Xia, Bo Hu The Sonic hedgehog (Shh) signaling pathway is recapitulated in response to ischemic injury. Here, we investigated the clinical implications of Shh protein in the ischemic stroke and explored the underlying mechanism. Intracerebroventricular injection of Shh, Cyclopamine, or anti-vascular endothelial growth factor (VEGF) was performed immediately after permanent middle cerebral artery occlusion (pMCAO) surgery and lasted for 7days (d). P...
Source: Neuroscience - April 26, 2017 Category: Neuroscience Source Type: research
Administration of secretoneurin is protective in hypoxic –ischemic neonatal brain injury predominantly in the hypoxic-only hemisphere
Publication date: 3 June 2017 Source:Neuroscience, Volume 352 Author(s): Anna Posod, Karina Wechselberger, Ruslan Iljitsch Stanika, Gerald J. Obermair, Karina Wegleiter, Eva Huber, Martina Urbanek, Ursula Kiechl-Kohlendorfer, Elke Griesmaier Neonatal brain injury is a problem of global importance. To date, no causal therapies are available. A substance with considerable therapeutic potential is the endogenous neuropeptide secretoneurin (SN), which has proven to be beneficial in adult stroke. The aim of this study was to assess its effect in neonatal hypoxic–ischemic brain injury models. In vitro, primary hippocampal neu...
Source: Neuroscience - April 19, 2017 Category: Neuroscience Source Type: research
Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke
Publication date: 3 June 2017 Source:Neuroscience, Volume 352 Author(s): Katarzyna Zalewska, Lin Kooi Ong, Sarah J. Johnson, Michael Nilsson, Frederick R. Walker Exposure to chronic stress following stroke has been shown, both clinically and pre-clinically, to impact negatively on the recovery process. While this phenomenon is well established, the specific mechanisms involved have remained largely unexplored. One obvious signaling pathway through which chronic stress may impact on the recovery process is via corticosterone, and its effects on microglial activity and vascular remodeling. In the current study, we were inte...
Source: Neuroscience - April 18, 2017 Category: Neuroscience Source Type: research
Role of thrombin-PAR1-PKC θ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood–brain barrier dysfunction in vitro
Publication date: 14 May 2017 Source:Neuroscience, Volume 350 Author(s): Takashi Machida, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Ikuya Kimura, Mariko Koga, Keiko Nakamoto, Atsushi Yamauchi, Yasufumi Kataoka Thrombin, an essential component in the coagulation cascade, participates in the pathogenesis of brain diseases, such as ischemic stroke, intracerebral hemorrhage, Alzheimer’s disease and Parkinson’s disease through blood–brain barrier (BBB) dysfunction. It is thought that the thrombin-matrix metalloproteinase (MMP)-9 axis is an important process in the pathogenesis of neurovascular disease, such as BBB ...
Source: Neuroscience - April 10, 2017 Category: Neuroscience Source Type: research
Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction
In this study, we explored the functional involvement of long non-coding RNA (lncRNA) SNHG14 and its potential regulatory mechanism in the activation of MCs. The mouse model of middle cerebral artery occlusion (MCAO) and microglia cell model of oxygen/glucose deprivation (OGD) were made. The expression of SNHG14, miR-145-5p and PLA2G4A protein expression was determined by quantitative real time PCR and western blot, respectively. Dual-luciferase assay was used to verify the direct binding of miR-145-5p and PLA2G4A. Flow cytometry was applied to measure neurons’ apoptosis. SNHG14 highly expressed in ischemic cerebral tiss...
Source: Neuroscience - March 26, 2017 Category: Neuroscience Source Type: research
Post-stroke treatment with 17 β-estradiol exerts neuroprotective effects in both normotensive and hypertensive rats
Publication date: 21 April 2017 Source:Neuroscience, Volume 348 Author(s): Wendy Stoop, Deborah De Geyter, Sofie Verachtert, Sofie Brouwers, Peggy Verdood, Jacques De Keyser, Ron Kooijman Although ischemic stroke is a major cause of death worldwide and the predominant cause of acquired disability, the only effective drug therapy that has been developed thus far is reperfusion by tissue plasminogen activator. Since most patients do not qualify for this treatment, new methods have to be developed. It is well known that estradiol (E2) exerts neuroprotective effects in different models of cerebral ischemia, but post-stroke tr...
Source: Neuroscience - March 15, 2017 Category: Neuroscience Source Type: research
Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia
Publication date: 4 May 2017 Source:Neuroscience, Volume 349 Author(s): Taichiro Imahori, Kohkichi Hosoda, Tomoaki Nakai, Yusuke Yamamoto, Yasuhiro Irino, Masakazu Shinohara, Naoko Sato, Takashi Sasayama, Kazuhiro Tanaka, Hiroaki Nagashima, Masaaki Kohta, Eiji Kohmura The metabolic pathophysiology underlying ischemic stroke remains poorly understood. To gain insight into these mechanisms, we performed a comparative metabolic and transcriptional analysis of the effects of cerebral ischemia on the metabolism of the cerebral cortex using middle cerebral artery occlusion (MCAO) rat model. Metabolic profiling by gas-chromatogr...
Source: Neuroscience - March 14, 2017 Category: Neuroscience Source Type: research
Quercetin inhibits acid-sensing ion channels through a putative binding site in the central vestibular region
Publication date: 21 April 2017 Source:Neuroscience, Volume 348 Author(s): Mohona Mukhopadhyay, Anurag Singh, S. Sachchidanand, Amal Kanti Bera Acid-sensing ion channels (ASICs) are associated with many pathophysiological processes, such as neuronal death during ischemic stroke, epileptic seizure and nociception. However, there is a dearth of ASIC-specific therapeutic blockers. Here we report that quercetin, a plant flavonoid, which is known for its neuroprotective effect, reversibly inhibits homomeric rat ASIC1a, ASIC2a and ASIC3 with an IC50 of about 2µM. Also, quercetin prevents low pH-induced intracellular calcium ri...
Source: Neuroscience - March 9, 2017 Category: Neuroscience Source Type: research
Transcriptomic analysis reveals differential activation of microglial genes after ischemic stroke in mice
Publication date: 21 April 2017 Source:Neuroscience, Volume 348 Author(s): Akbar Khan, Furong Ju, Wenguang Xie, Muhammad Tariq Hafeez, Xiaofeng Cheng, Zhijie Yang, Lirui Zhu, Ting Li, Shengxiang Zhang Microglia are immune cells in the brain and play a pivotal role in the progression of ischemic injury, but the gene expression and signaling pathways related to the activation of microglia following ischemia remain unclear. In our experiment, we used digital gene expression (DGE) analysis to profile the transcriptome of ischemic tissue in a photothrombosis model. DGE analysis identified that a total of 749 genes were differe...
Source: Neuroscience - March 7, 2017 Category: Neuroscience Source Type: research
Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia –ischemia
Publication date: 27 March 2017 Source:Neuroscience, Volume 346 Author(s): Xiaoxia Yang, Jianhua Cheng, Yubo Gao, Juan Ding, Xinli Ni In adult stroke models, the neuroprotective protein, Iduna, inhibits poly (ADP-ribose) polymerase-1 (PARP-1)-dependent cell death by decreasing apoptosis-inducing factor (AIF) nuclear translocation. Because the PARP1-dependent pathway and Iduna, which promotes AIF degradation, contribute to hypoxic–ischemic (HI) brain damage in the immature brain, we examined the relationship between Iduna expression and AIF nuclear translocation in the cerebral cortex of postnatal day 7 rats after HI. Ni...
Source: Neuroscience - January 31, 2017 Category: Neuroscience Source Type: research
Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats
In conclusion, our studies indicate that Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage.
Source: Neuroscience - January 19, 2017 Category: Neuroscience Source Type: research
Group comparison of cortical fiber connectivity map: An application between post-stroke patients and healthy subjects
This study demonstrated the feasibility of vertex-wise group comparison for evaluating cortical fiber connectivity density. The FiCD method has good intra- and inter-individual reproducibility, and accurately reflects the affected cortical regions in post-stroke patients. This method may be helpful for neuroscience research.
Source: Neuroscience - January 11, 2017 Category: Neuroscience Source Type: research
Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke
In this study, we have evaluated the impact of these two types of stroke in the cell survival and evolution of stroke, focusing on microglial cells, the first responders to cell injury. Two groups of heterozygote Cx3CR1-GFP reporter mice (to follow microglia) were subject to stroke injury either with coagulator-mediated occlusion or photothrombotic MCA damage. Microglial cells’ dynamics of activation and phagocytosis together with astrocytic response and leukocyte infiltration were characterized at 1, 3 and 7days after damage. Photothrombotic stroke delayed microglial and astrocytic invasion of the ischemic core and accu...
Source: Neuroscience - January 11, 2017 Category: Neuroscience Source Type: research
