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Source: Neuroscience
Condition: Ischemic Stroke
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Total 105 results found since Jan 2013.
Receptors, channel proteins, and enzymes involved in microglia-mediated neuroinflammation and treatments by targeting microglia in ischemic stroke
Publication date: Available online 18 February 2021Source: NeuroscienceAuthor(s): Kun Hou, Guichen Li, Jinlu Yu, Kan Xu, Wei Wu
Source: Neuroscience - February 18, 2021 Category: Neuroscience Source Type: research
Hypoxia Inducible Factor-1α (HIF-1α) Mediates NLRP3 Inflammasome-Dependent-Pyroptotic and Apoptotic Cell Death Following Ischemic Stroke
Publication date: Available online 22 September 2020Source: NeuroscienceAuthor(s): Qian Jiang, Xiaokun Geng, Johnathan Warren, Eric Eugene Paul Cosky, Shawn Kaura, Christopher Stone, Fengwu Li, Yuchuan Ding
Source: Neuroscience - September 23, 2020 Category: Neuroscience Source Type: research
Progressive gray matter atrophy and abnormal structural covariance network in ischemic pontine stroke
Publication date: Available online 3 September 2020Source: NeuroscienceAuthor(s): Ying Wei, Caihong Wang, Jingchun Liu, Peifang Miao, Luobing Wu, Yingying Wang, Kaiyu Wang, Jingliang Cheng
Source: Neuroscience - September 3, 2020 Category: Neuroscience Source Type: research
Cofilin inhibition by limk1 reduces rod formation and cell apoptosis after ischemic stroke
Publication date: Available online 19 July 2020Source: NeuroscienceAuthor(s): Bin Chen, Wanqing Lin, Wan Qi, Shibin Li, Zhenfeng Hong, Hongjia Zhao
Source: Neuroscience - July 20, 2020 Category: Neuroscience Source Type: research
Blockade of Nogo-A/Nogo-66 receptor 1 (NgR1) Inhibits Autophagic Activation and Prevents Secondary Neuronal Damage in the Thalamus after Focal Cerebral Infarction in Hypertensive Rats
This study aimed to investigate the potential roles of Nogo-A/Nogo-66 receptor 1 (NgR1) in autophagic activation in the ipsilateral thalamus after cerebral infarction. Focal neocortical infarction was established using the middle cerebral artery occlusion (MCAO) method. Secondary damage in the ipsilateral thalamus was assessed by Nissl staining and immunostaining. The expression of Nogo-A, NgR1, Rho-A and Rho-associated coiled-coil containing protein kinase 1 (ROCK1) as well as autophagic flux were evaluated by immunofluorescence and immunoblotting. The roles of Nogo-A–NgR1 signaling in autophagic activation were determi...
Source: Neuroscience - February 22, 2020 Category: Neuroscience Source Type: research
Sleep-restriction inhibits neurogenesis through decreasing the infiltration of CD169+ macrophages to ischemic brain after stroke
In this study, mice were subjected to 60 minutes of cerebral ischemia followed by reperfusion. The SR protocol was accomplished by depriving mice of sleep for 20 hours/day for 14 days starting at 14 days post-ischemia. We found that SR increased CD169+ macrophages infiltration into the ischemic brain parenchyma and inhibited neurogenesis and functional recovery. SR decreased CD169+ macrophages infiltration into the choroid plexus (CP) and cerebrospinal fluid (CSF), accompanied by increased expression of Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) and intercellular adhesion molecule (ICAM-1) via IFN-γ/IFN-γR signaling in the...
Source: Neuroscience - February 19, 2020 Category: Neuroscience Source Type: research
Blockade of Nogo-A/NgR1 inhibits autophagic activation and prevents secondary neuronal damage in the thalamus after focal cerebral infarction in hypertensive rats
This study aimed to investigate the potential roles of Nogo-A/Nogo-66 receptor 1 (NgR1) in autophagic activation in the ipsilateral thalamus after cerebral infarction. Focal neocortical infarction was established using the middle cerebral artery occlusion (MCAO) method. Secondary damage in the ipsilateral thalamus was assessed by Nissl staining and immunostaining. The expression of Nogo-A, NgR1, Rho-A and Rho-associated coiled-coil containing protein kinase 1 (ROCK1) as well as autophagic flux were evaluated by immunofluorescence and immunoblotting. The roles of Nogo-A-NgR1 signaling in autophagic activation were determine...
Source: Neuroscience - February 16, 2020 Category: Neuroscience Source Type: research
Exercise plus pharmacological neuromodulation of synaptic inhibition enhance motor function recovery after ischemic stroke
ConclusionsThis study indicated that exercise combined with low-level inhibition of GABAA receptors after stroke could facilitate the recovery of motor function accompanied by BDNF upregulation in the ipsilateral M1. Therefore, this study provides a novel insight of pharmacological neuromodulation into stroke rehabilitation.
Source: Neuroscience - January 25, 2020 Category: Neuroscience Source Type: research
Overexpression of microRNA-9a-5p ameliorates NLRP1 inflammasome-mediated ischemic injury in rats following ischemic stroke
Publication date: Available online 16 January 2020Source: NeuroscienceAuthor(s): Cao yuze, Zhang huixue, Lu xiaoyu, Wang Jianjian, Zhang xiaoming, Sun shengnan, Bao zhonglei, Tian wenqi, Ning shangwei, Wang lihua, Cui liyingAbstractThe nucleotide oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing protein 1 (NLRP1) inflammasome has been shown to contribute to brain injury after ischemic stroke. Our previous study showed that microRNA-9a-5p (miR-9a-5p) ameliorates ischemic injury by regulating neuronal autophagy in rats subjected to middle cerebral artery occlusion (MCAO) surgery. The aims of this study...
Source: Neuroscience - January 17, 2020 Category: Neuroscience Source Type: research
Corrigendum to “Transcriptomic Analysis Reveals Differential Activation of Microglial Genes after Ischemic Stroke in Mice” Neuroscience 348 (2017) 212–227
Publication date: Available online 6 January 2020Source: NeuroscienceAuthor(s): Akbar Khan, Furong Ju, Wenguang Xie, Muhammad Tariq Hafeez, Xiaofeng Cheng, Zhijie Yang, Lirui Zhu, Ting Li, Shengxiang Zhang
Source: Neuroscience - January 7, 2020 Category: Neuroscience Source Type: research
Neuroprotective action of teriflunomide in a mouse model of transient middle cerebral artery occlusion
In this study, we investigated the effects of teriflunomide on brain edema, neurologic deficits, infarct volume, neuroinflammation, blood-brain barrier (BBB) permeability, and neurogenesis in a mouse model of transient middle cerebral artery occlusion (tMCAO). tMCAO mice treated with teriflunomide showed lower brain water content on day 3, milder neurologic deficits and smaller infarct volume on day 7 than those treated with vehicle. Additionally, mice received teriflunomide had fewer activated Iba-1-positive microglia and lower protein levels of interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and 3-Nitrotyrosine (3-NT...
Source: Neuroscience - December 28, 2019 Category: Neuroscience Source Type: research
Neuroprotection by insulin-like growth factor-1 in rats with ischemic stroke is associated with microglial changes and a reduction in neuroinflammation
Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): Ahmad Serhan, Joeri L. Aerts, EWGM Boddeke, Ron KooijmanAbstractWe and others have shown that insulin-like growth factor-1 (IGF-1) is neuroprotective when administered systemically shortly following stroke. In the current study, we addressed the hypothesis that microglia mediate neuroprotection by IGF-1 following ischemic stroke. Furthermore, we investigated whether IGF-1 modulates pro- and anti-inflammatory mediators in ischemic brain with a special reference to microglia. Ischemic stroke was induced in normal conscious Wistar rats by infusi...
Source: Neuroscience - December 16, 2019 Category: Neuroscience Source Type: research
Pseudoginsenoside-F11 Accelerates Microglial Phagocytosis of Myelin Debris and Attenuates Cerebral Ischemic Injury Through Complement Receptor 3
Publication date: Available online 29 November 2019Source: NeuroscienceAuthor(s): Yinglu Liu, Chunfu Wu, Zongjuan Hou, Xiaoxiao Fu, Linlin Yuan, Shibo Sun, Haotian Zhang, Depeng Yang, Xuechun Yao, Jingyu YangAbstractAfter ischemic stroke, the degenerated myelin caused by ischemic injury cannot be rapidly cleared away by microglia and interferes with the recovery process. Complement receptor 3 (CR3, CD11b/CD18), belonging to β2 integrin family primarily expressed in phagocytes, is involved in the microglial phagocytosis of myelin debris. We previously found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, exer...
Source: Neuroscience - November 30, 2019 Category: Neuroscience Source Type: research
Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway
Publication date: Available online 11 November 2019Source: NeuroscienceAuthor(s): Rui Zhao, Miaofa Ying, Shenglong Gu, Wei Yin, Yanwei Li, Hong Yuan, Sanhua Fang, Mingxing LiAbstractMicroglia activation plays a key role in regulating inflammatory and immune reaction during cerebral ischemia and it exerts pro-inflammatory or anti-inflammatory effect depending on M1/M2 polarization phenotype. Cysteinyl leukotriene 2 receptor (CysLT2R) is a potent inflammatory mediator receptor, and involved in cerebral ischemic injury, but the mechanism of CysLT2R regulating inflammation and neuron damage remains unclear. Here, we found that...
Source: Neuroscience - November 12, 2019 Category: Neuroscience Source Type: research
USP18 Overexpression Protects against Focal Cerebral Ischemia Injury in Mice by Suppressing Microglial Activation
This study aims to determine whether USP18 expression protects against brain damage in ischemic models of stroke. We investigated USP18 expression, overexpression, and knockout under ischemic conditions in vitro and in vivo. Using BV2 microglial cells under oxygen and glucose deprivation (OGD) and 60 min transient middle cerebral artery occlusion (MCAO) in mice as models of ischemia, we assessed the infarct volume, the extent of neurogenesis, the expression of proinflammatory cytokines and Janus Kinases (JAKs)/Signal Transducer and Activator of Transcription (STAT) pathway members. BV2 cells under OGD for 0, 6, 12, or 24 h...
Source: Neuroscience - September 10, 2019 Category: Neuroscience Source Type: research
