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Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats
Publication date: 2 June 2016 Source:Neuroscience, Volume 324 Author(s): J. Hu, B. Liu, Q. Zhao, P. Jin, F. Hua, Z. Zhang, Y. Liu, K. Zan, G. Cui, X. Ye High-mobility group box 1 (HMGB1), a ligand of receptor for advanced glycation endproducts (RAGE), functions as a proinflammatory factor. It is mainly involved in inflammatory activation and contributes to the initiation and progression of stroke. By using a model of transient middle cerebral artery occlusion (MCAo) in type 2 diabetic rats, we investigated the changes of pro-inflammation mediators, blood–brain barrier (BBB) leakage and functional outcome afte...
Source: Neuroscience - March 13, 2016 Category: Neuroscience Source Type: research

Hyperglycemia reduces functional expression of astrocytic Kir4.1 channels and glial glutamate uptake
Publication date: 3 December 2015 Source:Neuroscience, Volume 310 Author(s): D.E. Rivera-Aponte, M.P. Méndez-González, A.F. Rivera-Pagán, Y.V. Kucheryavykh, L.Y. Kucheryavykh, S.N. Skatchkov, M.J. Eaton Diabetics are at risk for a number of serious health complications including an increased incidence of epilepsy and poorer recovery after ischemic stroke. Astrocytes play a critical role in protecting neurons by maintaining extracellular homeostasis and preventing neurotoxicity through glutamate uptake and potassium buffering. These functions are aided by the presence of potassium channels, such as Kir4.1 inward...
Source: Neuroscience - October 4, 2015 Category: Neuroscience Source Type: research

Type 2 diabetes reduces the proliferation and survival of oligodendrocyte progenitor cells in ishchemic white matter lesions
Publication date: 19 March 2015 Source:Neuroscience, Volume 289 Author(s): Y. Yatomi , R. Tanaka , Y. Shimada , K. Yamashiro , M. Liu , Y. Mitome-Mishima , N. Miyamoto , Y. Ueno , T. Urabe , N. Hattori Diabetes mellitus (DM) is a major risk factor for stroke and it exacerbates tissue damage after ischemic insult. Diabetes is one of the important causes of the progression of white matter lesion, however, the pathological mechanisms remain unclear. The present study evaluated the influences of type 2 DM on ischemic subcortical white matter injury and the recruitment of oligodendrocyte progenitor cells (OPCs) under chronic ...
Source: Neuroscience - January 31, 2015 Category: Neuroscience Source Type: research