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The Impact of the Ketogenic Diet on Glial Cells Morphology. A Quantitative Morphological Analysis
Publication date: Available online 18 June 2019Source: NeuroscienceAuthor(s): K. Gzielo, Z. Soltys, Z. Rajfur, Z.K. SetkowiczAbstractKetogenic diet is reported to protect against cognitive decline, drug-resistant epilepsy, Alzheimer's Disease, damaging effect of ischemic stroke and many neurological diseases. Despite mounting evidence that this dietary treatment works, the exact mechanism of its protective activity is largely unknown. Ketogenic diet acts systemically, not only changing GABA signaling in neurons, but also influencing the reliance on mitochondrial respiration, known to be disrupted in many neurological disea...
Source: Neuroscience - June 18, 2019 Category: Neuroscience Source Type: research

Intravenous Infusion of Mesenchymal Stem Cells Improves Impaired Cognitive Function in a Cerebral Small Vessel Disease Model
Publication date: Available online 16 April 2019Source: NeuroscienceAuthor(s): Masahito Nakazaki, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Junpei Suzuki, Yuichi Sasaki, Hiroshi Nagahama, Kazuo Hashi, Jeffery D. Kocsis, Osamu HonmouAbstractCerebral small vessel disease (CSVD) is not only a cause of vascular dementia (VD) but also a contributing factor to Alzheimer's disease (AD). The essential pathological feature of CSVD is the disruption of blood–brain barrier (BBB). Dysfunction of BBB due to degeneration of both endothelial cells and pericytes in capillaries leads to neuronal damage and progressive brain atr...
Source: Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

Abolished perineuronal nets and altered parvalbumin-immunoreactivity in the nucleus reticularis thalami of wildtype and 3xTg mice after experimental stroke
In conclusion, these data confirm PNs as highly sensitive constituents of the ECM along with impaired neuronal integrity of GABAergic neurons. Therefore, specific targeting of ECM components might appear as a promising strategy for future treatment strategies in stroke.
Source: Neuroscience - September 23, 2016 Category: Neuroscience Source Type: research

Decline of microtubule-associated protein tau after experimental stroke in differently aged wild-type and 3xTg mice with Alzheimer-like alterations
In conclusion, microtubule-associated protein tau was robustly identified as a highly sensitive cytoskeletal constitute under ischemic conditions, suggesting a pivotal role during the transition process toward long-lasting tissue damage. Consequently, cytoskeletal elements appear as promising targets for novel therapeutic approaches with the objective to impede ischemia-induced irreversible cellular degradation.
Source: Neuroscience - June 3, 2016 Category: Neuroscience Source Type: research