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Impact of atrial fibrillation burden on cognitive function after left atrial ablation – Results of the MACPAF study
Publication date: Available online 25 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Juliane Herm, Alexander Schirdewan, Lydia Koch, Alexander Wutzler, Jochen B. Fiebach, Matthias Endres, Ute A. Kopp, Karl Georg HaeuslerAbstractAtrial fibrillation (AF) is associated with cognitive decline and dementia irrespective of AF-related ischemic stroke. We investigated whether AF burden after ablation in patients with symptomatic paroxysmal AF has an impact on cognitive function. After enrolment to the prospective MACPAF study, study patients received an insertable loop recorder (ILR) and underwent serial neurologic...
Source: Journal of Clinical Neuroscience - January 26, 2020 Category: Neuroscience Source Type: research

Clinical characteristics and treatment outcomes among stroke patients hospitalized to Nekemte referral hospital, western Ethiopia
ConclusionAbout two third of the patients had poor treatment outcome. Educational status and mean length of hospital stays were independent predictors of poor treatment out-comes. An emergency care setup capable of early patient evaluation, identification and management of stroke complications is crucial to overcome early stroke related mortality.
Source: Journal of Clinical Neuroscience - January 25, 2020 Category: Neuroscience Source Type: research

The comparative effects of unilateral and bilateral transcranial direct current stimulation on motor learning and motor performance: A systematic review of literature and meta-analysis
Publication date: Available online 20 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Sara Halakoo, Fatemeh Ehsani, Motahareh Hosnian, Maryam Zoghi, Shapour JaberzadehAbstractApplication of unilateral tDCS (Uni-tDCS) vs. bilateral tDCS (Bi-tDCS) is another important factor that can affect the physiological results of tDCS intervention on motor learning and motor performance. According to the evidence, some studies indicated that motor performance or motor learning are facilitated in healthy individuals by application of the Bi-tDCS more than the Uni-tDCS. On the other hand, some studies showed that there was...
Source: Journal of Clinical Neuroscience - January 21, 2020 Category: Neuroscience Source Type: research

Cerebral collaterals and stroke in patients with isolated carotid artery dissections
Publication date: Available online 11 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Ching-Jen Chen, Ilana E. Green, Bradford B. Worrall, Andrew M. SoutherlandAbstractTo investigate potential association between collateral arterial supply and stroke in patients with isolated internal carotid artery dissection (iCeAD). We hypothesized a lower risk of stroke in patients with more robust collateral supply. This is a single-center, retrospective review of iCeAD patients between 1994 and 2018. iCeAD patients with sufficient neuroimaging data were included. Patients were categorized based on cerebral infarction (...
Source: Journal of Clinical Neuroscience - January 13, 2020 Category: Neuroscience Source Type: research

The role of statins in cardioembolic stroke
ConclusionsThe use of statins in patients with cardioembolic stroke may be beneficial in some cases, preventing stroke recurrence and improving functional outcomes.
Source: Journal of Clinical Neuroscience - December 25, 2019 Category: Neuroscience Source Type: research

Thrombolysis safety and effectiveness in acute ischemic stroke patients with pre-morbid disability
ConclusionPatients with mRS 2 and 3 may benefit from rt-PA with a moderate risk of sICH and mortality.
Source: Journal of Clinical Neuroscience - December 25, 2019 Category: Neuroscience Source Type: research

Up-regulation of Sirt1/miR-149-5p signaling may play a role in resveratrol induced protection against ischemia via p53 in rat brain
In conclusion, our findings suggest that miR-149-5p could play a regulatory role in neuronal cell death via Sirt1/p53 axis, which offers a new target for novel therapeutic interventions during acute ischemic stroke.
Source: Journal of Clinical Neuroscience - December 20, 2019 Category: Neuroscience Source Type: research

Prevalence of hypohydration and its association with stroke severity and independence outcomes in acute ischemic stroke patients
Publication date: Available online 11 December 2019Source: Journal of Clinical NeuroscienceAuthor(s): Alex Buoite Stella, Marina Gaio, Giovanni Furlanis, Mariana Ridolfi, Miloš Ajčević, Arianna Sartori, Paola Caruso, Shawnda A. Morrison, Marcello Naccarato, Paolo ManganottiAbstractHypohydration has been suggested increasing the risk of vascular diseases, and it is associated with poor prognosis and worse functional outcome in stroke. Most studies have used blood parameters to determine patients’ hydration status. The aim of this study was to measure urine osmolality (uOsm) and its influence on stroke severity and inde...
Source: Journal of Clinical Neuroscience - December 12, 2019 Category: Neuroscience Source Type: research

The role of ASPECTs in patient selection for endovascular therapy – CTA source images versus noncontrast CT
In conclusion, CTA-SI ASPECTs in patient selection for ET seems to be more useful than NCCT ASPECTs. However, both scoring modalities were not found to be independent predictors of good outcome. Outcomes are changeable for the younger population who could continue their lives with mild or no deficits despite having a relatively low initial ASPECTs.
Source: Journal of Clinical Neuroscience - November 5, 2019 Category: Neuroscience Source Type: research

Ischemic stroke caused by giant cell arteritis associated with pulmonary adenocarcinoma
We describe a 77-year-old man with a sudden onset of dizziness, vomiting, and gait disturbances. Following imaging studies, a diagnosis of bulbar ischemic stroke with left vertebral artery stenosis was made. Based on a history of polymyalgia rheumatica, on laboratory tests, and brain digital subtraction angiography, a diagnosis of GCA was advanced and the patient underwent high-dose steroidal therapy. After a total body 18-FGD PET imaging, a pulmonary adenocarcinoma was found.Vertebral artery involvement is a rare but important occurrence in GCA as it carries a high mortality rate, and may require a vigorous therapeutic ap...
Source: Journal of Clinical Neuroscience - November 5, 2019 Category: Neuroscience Source Type: research

Clinical outcomes of moderate to severe acute ischemic stroke in a telemedicine network
The objective of this study was to analyze clinical and imaging based outcomes of moderate to severe stroke following treatment with thrombolysis, thrombectomy or a combination of both in a telemedicine network. Data of this retrospective study was abstracted from the institutional telestroke database. Patients with a National Institute of Health Stroke Scale score (NIH-SS ≥ 10) were included into the study. Primary outcome measure was the difference in NIH-SS at admission compared to discharge from the hospital. Secondary outcome measure was the discharge disposition defined as favorable (discharge to home or rehabi...
Source: Journal of Clinical Neuroscience - November 2, 2019 Category: Neuroscience Source Type: research

Early cardiovascular function and associated hemodynamics in adults with isolated moderate-severe traumatic brain injury: A pilot study
ConclusionSystemic hemodynamic parameters were consistent with an early catecholamine-excess state. While reduced systolic function was associated with lower SVI, there was no relationship with reduced cerebral perfusion, possibly due to normal MAP.
Source: Journal of Clinical Neuroscience - November 2, 2019 Category: Neuroscience Source Type: research

Epidemiologic features and risk factors of sepsis in ischemic stroke patients admitted to intensive care: A prospective cohort study
ConclusionsThis study showed that ICU patients with severe ischemic stroke were more susceptible to sepsis during the hospital course.
Source: Journal of Clinical Neuroscience - September 20, 2019 Category: Neuroscience Source Type: research

Can initial sarcopenia affect poststroke rehabilitation outcome?
This study investigated the association between the presence of sarcopenia, measured by nonhemiplegic grip strength, and the level of functional recovery, measured by the modified Rankin Scale (mRS) at six months after stroke. We performed a retrospective cohort analysis of a prospectively maintained database of 194 hemiplegic poststroke patients, who had been admitted to the Department of Rehabilitation Medicine of a university-affiliated hospital. At 6 months after stroke, 72.2% of patients had mRS score>3, with more women (81.0% vs. 66.0%, p = 0.024) showing poor recovery. Both men (51.3% vs. 35.9%, p = 0.041)...
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Efficacy of RehaCom cognitive rehabilitation software in activities of daily living, attention and response control in chronic stroke patients
ConclusionsIn conclusion, RehaCom cognitive rehabilitation software has improvement effect on ADL, attention and response control in patients with chronic stroke. Our study reveals a new information about the efficacy of computerized training in the rehabilitation of stroke patients.
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

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