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Source: Journal of Clinical Neuroscience
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Total 163 results found since Jan 2013.
Safety and efficacy of early antiplatelet therapy in acute ischemic stroke patients receiving endovascular treatment: A systematic review and meta-analysis
ConclusionsEarly antiplatelet therapy may be safe in acute ischemic stroke patients, further studies are needed to confirm the efficacy.
Source: Journal of Clinical Neuroscience - May 30, 2019 Category: Neuroscience Source Type: research
When does spasticity in the upper limb develop after a first stroke? A nationwide observational study on 861 stroke patients
This study investigated the time taken for upper extremity spasticity to develop and its regional difference after first-ever stroke onset in a nationwide multicenter study in South Korea. The retrospective observational study included 861 individuals with post-stroke spasticity in the upper limbs. Spasticity in the upper extremity joints was defined as a modified Ashworth Scale score ≥1. The median time to develop upper limb spasticity after stroke onset was 34 days. 12% of post-stroke spasticity cases developed between 2 months and 3 months and 13% developed after 3 months from onset. At the time of diagnosis o...
Source: Journal of Clinical Neuroscience - May 12, 2019 Category: Neuroscience Source Type: research
A troponin study on patients with ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage: Type II myocardial infarction is significantly associated with stroke severity, discharge disposition and mortality
Publication date: Available online 20 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ayham M. Alkhachroum, Benjamin Miller, Tarek Chami, Curtis Tatsuoka, Cathy SilaAbstractTroponin elevations due to Type II myocardial infarction (T2MI) are associated with hemorrhagic and ischemic strokes but there is little data on stroke severity, troponin elevation and outcome. We studied 1655 patients from a tertiary medical center between 1/2013-4/2015 using multivariate regression analysis for demographics, vascular risk factors, admission stroke severity, laboratory tests, echocardiogram results and discharge dispositio...
Source: Journal of Clinical Neuroscience - April 21, 2019 Category: Neuroscience Source Type: research
Fabry’s disease and stroke: Effectiveness of enzyme replacement therapy (ERT) in stroke prevention, a review with meta-analysis
ConclusionOur meta-analysis based on the currently available data showed that ERT for Fabry’s disease has beneficial effect on stroke prevention. Female carriers and atypically affected males could be started on ERT as soon as diagnosis is made. Further studies are warranted to support the role of ERT in stroke prevention.
Source: Journal of Clinical Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research
Intravenous thrombolysis with tissue-plasminogen activator in small vessel occlusion
This study included 2482 patients: 193 in the IV-TPA group and 2289 in the control group. After adjusting covariates, IV-TPA treatment was associated with an increased mRS 0-1 outcome (adjusted OR [95% CI], 1.56 [1.06–2.29]; P = 0.0249), but was not significantly associated with a favorable mRS shift (1.33 [0.98–1.81]; P = 0.0709). SICH and 3-month death occurred in three (1.6%) and none in the IV-TPA group versus one (0.04%) and 16 (0.7%) in the control group. In subgroup analyses, the IV-TPA effect appeared significantly greater in patients aged ≥80 versus <80 for mRS score distribution (Pinteraction ...
Source: Journal of Clinical Neuroscience - April 4, 2019 Category: Neuroscience Source Type: research
Vasospasm as a major complication after acute mechanical thrombectomy with stent retrievers
ConclusionStent retrievers appear to cause vasospasm more than expected when including mild cases. Vasospasm tends to occur especially in cases with IV-tPA; prognosis is generally good, and it rarely requires any treatment.
Source: Journal of Clinical Neuroscience - March 21, 2019 Category: Neuroscience Source Type: research
Guillain-Barré syndrome as a complication of hypertensive basal ganglia haemorrhage
We present a case of a 70-year-old hypertensive woman who developed global weakness, eventually becoming quadriplegic, during an inpatient stay for treatment of a basal ganglia haemorrhagic stroke. Guillain-Barré syndrome was confirmed and treatment initiated. She responded well to intravenous immunoglobulin treatment and then subsequently continued with rehabilitation.There have been a few case reports of GBS as a complication of spontaneous intracranial haemorrhage (ICH) or traumatic brain injury. It may not be a coincidence that our patient developed GBS shortly after presentation. There may be an immunological explana...
Source: Journal of Clinical Neuroscience - March 7, 2019 Category: Neuroscience Source Type: research
Angioplasty and stenting for severe symptomatic atherosclerotic stenosis of intracranial vertebrobasilar artery
Publication date: Available online 6 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yu Zhou, Li Wang, Jian-Rong Zhang, Kai Zhou, Jie Shuai, Zi-Li Gong, Yong Liu, Fei Wei, Yu-Fu Han, Lin Shen, Qing-Wu YangAbstractThis retrospective study is to investigate the safety and efficacy of the stent implanting for treating severe symptomatic atherosclerotic stenosis of the intracranial vertebrobasilar artery (ICVBA). 213 patients who had undergone intervention for severe symptomatic ICVBA stenosis between September 2012 to May 2018 were enrolled into this study. Among the 213 enrolled patients, 210 patients (98.6%) ob...
Source: Journal of Clinical Neuroscience - March 6, 2019 Category: Neuroscience Source Type: research
Platelet-to-neutrophil ratio is a prognostic marker for 90-days outcome in acute ischemic stroke
In this study, a total of 400 AIS patients were included. Demographic, clinical, laboratory data were collected on admission, and PNR was calculated according to platelet and neutrophil counts on admission. The prognosis after 3 months was evaluated by the Barthel index (BI), where BI ≤85 was defined as poor prognosis and BI>85 was defined as good prognosis. Regression analyses were performed, adjusting for confounders. (1) Compared with good prognosis group, PNR level on admission in poor prognosis group was significantly lower, the difference between the two groups was statistically significant (P < 0.05). (2...
Source: Journal of Clinical Neuroscience - February 6, 2019 Category: Neuroscience Source Type: research
Asymptomatic moderate carotid artery stenosis with intraplaque hemorrhage: Progression of degree of stenosis and new ischemic stroke
Publication date: Available online 4 February 2019Source: Journal of Clinical NeuroscienceAuthor(s): Kiyofumi Yamada, Shinichi Yoshimura, Manabu Shirakawa, Kazutaka Uchida, Shigehiro Nakahara, Shuji Nishida, Yasuhiro Iwamoto, Yoshikazu Sato, Masanori KawasakiAbstractCarotid intraplaque hemorrhage (IPH) plays a critical role in the progression of carotid atherosclerotic disease. IPH was associated with high intensity signal (HIS) in the plaque on Maximum intensity projection (MIP) images from routine three dimensional magnetic resonance imaging (3D-TOF MRA). The aim of this study was to evaluate the relationships among HIS,...
Source: Journal of Clinical Neuroscience - February 5, 2019 Category: Neuroscience Source Type: research
The different clinical value of susceptibility vessel sign in acute ischemic stroke patients under different interventional therapy: A systematic review and meta-analysis
Publication date: Available online 1 February 2019Source: Journal of Clinical NeuroscienceAuthor(s): Mingsu Liu, Lin Li, Guangqin LiAbstractAcute ischemic stroke (AIS) subtype, one of the most important factors for selecting therapeutic strategies, is difficult to be accurately diagnosed at admission sometimes. The magnetic susceptibility effect of deoxygenated hemoglobin in red thrombi appeared as hypointense signals in magnetic resonance imaging (MRI) scans. The prognostic value of susceptibility vessel sign (SVS) for stroke subtype, recanalization and outcomes in AIS patients will be comprehensively determined in the pr...
Source: Journal of Clinical Neuroscience - February 1, 2019 Category: Neuroscience Source Type: research
Correlation between pre-admission blood pressure and outcome in a large telestroke cohort
ConclusionsThis study displays better clinical outcomes at latest follow-up when compared to current international TS studies. SBP during transportation to the hub hospital did not prove to be a useful prognostic metric. However, future studies should address the limitations of this study to confirm these findings.
Source: Journal of Clinical Neuroscience - January 17, 2019 Category: Neuroscience Source Type: research
Fluid and energy intake in stroke patients during acute hospitalization in a stroke unit
Publication date: Available online 14 January 2019Source: Journal of Clinical NeuroscienceAuthor(s): Alex Buoite Stella, Marina Gaio, Giovanni Furlanis, Pauline Douglas, Marcello Naccarato, Paolo ManganottiAbstractProper hydration and nutrition have been found to be contributing factors to a better recovery in patients after stroke. A better knowledge of factors influencing fluid and energy intake may contribute to a better care of the acute stroke patient. Aim of this study was to describe hydration status, fluid intake, and energy intake of stroke patients during acute hospitalization in a stroke unit. A retrospective de...
Source: Journal of Clinical Neuroscience - January 15, 2019 Category: Neuroscience Source Type: research
Implementation of multiphase computed tomography angiography in management of patients with acute ischemic stroke in clinical practice
Publication date: Available online 19 December 2018Source: Journal of Clinical NeuroscienceAuthor(s): Nattaphol Uransilp, Pornpatr A. Dharmasaroja, Arvemas Watcharakorn, Sombat MuengtaweepongsaAbstractMultiphase computed tomography angiography (CTA) provides information on the status of major cranial arteries and extent of brain collateralization. The purpose of the study was to determine whether implementation of multiphase CTA in routine clinical practice was feasible, safe and useful. Patients with acute ischemic stroke (NIHSS ≥ 6) were included. Multiphase CTA was performed. Duration of performing multiphase CTA,...
Source: Journal of Clinical Neuroscience - December 20, 2018 Category: Neuroscience Source Type: research
Blood microRNA-93 as an indicator for diagnosis and prediction of functional recovery of acute stroke patients
Publication date: Available online 19 December 2018Source: Journal of Clinical NeuroscienceAuthor(s): Qingfeng Ma, Guangwen Li, Zhen Tao, Jue Wang, Rongliang Wang, Ping Liu, Yumin Luo, Haiping ZhaoAbstractThe present study evaluated the diagnostic and predictive potential of microRNA-93 in acute ischemic stroke (AIS) patients within 6 h of stroke onset and its regulation on microglial inflammation in vitro. Our results showed that the miR-93 levels in plasma and neutrophil detected by real-time PCR were evidently reduced in AIS patients, and Pearson's correlation analysis showed that miR-93 levels in plasma and neutrophi...
Source: Journal of Clinical Neuroscience - December 20, 2018 Category: Neuroscience Source Type: research
