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Peritonitis affects the relationship between low-density lipoprotein cholesterol and cardiovascular events in peritoneal dialysis patients
ConclusionsPD patients with lower baseline LDL-C had a higher risk of peritonitis. The effect of LDL-C on CV events and mortality was different by the presence of peritonitis events.
Source: Canadian Journal of Cardiology - August 30, 2019 Category: Cardiology Source Type: research

Anticoagulation in Patients with Advanced Chronic Kidney Disease: Walking the Fine Line between Benefit and Harm
Publication date: Available online 11 July 2019Source: Canadian Journal of CardiologyAuthor(s): Januvi Jegatheswaran, Gregory L. Hundemer, David Massicotte-Azarniouch, Manish M. SoodAbstractChronic kidney disease affects over 3 million Canadians and is highly associated with cardiovascular diseases that require anticoagulation, such as atrial fibrillation and venous thromboembolism. Patients with chronic kidney disease are at a problematic crossroads; they are at high risk of both thrombotic conditions requiring anticoagulation and bleeding complications due to anticoagulation. The limited high-quality clinical evidence to...
Source: Canadian Journal of Cardiology - July 12, 2019 Category: Cardiology Source Type: research

Outcome Of Patients Undergoing Transcatheter Implantation Of Aortic Valve With Previous Mitral Valve Prosthesis (OPTIMAL STUDY)
ConclusionsTAVR in patients with a previous mitral prosthesis appears safe and feasible, with good hemodynamic results at 30-day and at longer term follow-up.
Source: Canadian Journal of Cardiology - April 16, 2019 Category: Cardiology Source Type: research

Early vs Late Surgery for Patients With Endocarditis and Neurological Injury: A Systematic Review and Meta-analysis
ConclusionsAvailable observational data support delaying surgery by 7-14 days if possible in IE complicated by ischemic stroke and> 21 days in hemorrhagic stroke to decrease perioperative mortality and neurological exacerbation rates. Randomized trials are needed for definitive guidance.RésuméIntroductionLe moment de l’intervention chirurgicale lors d’une endocardite infectieuse (EI) accompagnée d’événements neurologiques reste controversé. Les lignes directrices pertinentes de la Société reposent chacune sur un petit nombre d’études observationnelles. La présente méta-analyse a été conçue pour recher...
Source: Canadian Journal of Cardiology - August 29, 2018 Category: Cardiology Source Type: research

Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults
Publication date: May 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 5 Author(s): Alexander A. Leung, Stella S. Daskalopoulou, Kaberi Dasgupta, Kerry McBrien, Sonia Butalia, Kelly B. Zarnke, Kara Nerenberg, Kevin C. Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Sheldon W. Tobe, Marcel Ruzicka, Kevin D. Burns, Michel Vallée, G.V. Ramesh Prasad, Steven E. Gryn, Ross D. Feldman, Peter Selby, Andrew Pipe, Ernesto L. Schiffrin, Philip A. McFarlane, Paul Oh, Robert A. Hegele, Milan Khara, Thomas W. Wilson, S. Brian Penner, Ellen Bu...
Source: Canadian Journal of Cardiology - April 25, 2017 Category: Cardiology Source Type: research

Hypertension Canada ’s 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults
Publication date: Available online 10 March 2017 Source:Canadian Journal of Cardiology Author(s): Alexander A. Leung, Stella S. Daskalopoulou, Kaberi Dasgupta, Kerry McBrien, Sonia Butalia, Kelly B. Zarnke, Kara Nerenberg, Kevin C. Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Sheldon W. Tobe, Marcel Ruzicka, Kevin D. Burns, Michel Vallée, G. V. Ramesh Prasad, Steven E. Gryn, Ross D. Feldman, Peter Selby, Andrew Pipe CM, Ernesto L. Schiffrin, Philip A. McFarlane, Paul Oh, Robert A. Hegele, Milan Khara, Thomas W. Wilson, S. Brian Penner, El...
Source: Canadian Journal of Cardiology - March 9, 2017 Category: Cardiology Source Type: research

Warfarin and the risk of stroke and bleeding in patients with atrial fibrillation receiving dialysis: A systematic review and meta-analysis
Conclusion Observational studies suggest that warfarin was not associated with a clear benefit or harm among patients who have atrial fibrillation and are receiving dialysis. These estimates were limited by study heterogeneity including the inability to account for a number of important confounders such as the time in the therapeutic range. Given the high prevalence of atrial fibrillation, stroke, and bleeding complications in this population, well-designed clinical trials of warfarin and other anti-coagulants are urgently needed. Teaser Patients with atrial fibrillation receiving maintenance dialysis are at a high risk of...
Source: Canadian Journal of Cardiology - February 20, 2017 Category: Cardiology Source Type: research

The Development And Feasibility Assessment Of Canadian Quality Indicators For Atrial Fibrillation
Publication date: Available online 27 February 2016 Source:Canadian Journal of Cardiology Author(s): Jafna L. Cox, Sulan Dai, Yanyan Gong., Robert McKelvie, M. Sean McMurtry, Garth H. Oakes, Allan Skanes, Atul Verma, Stephen B. Wilton, D. George Wyse In 2010, the Canadian Cardiovascular Society (CCS) embarked on an initiative to develop pan-Canadian quality indicators (QIs) and standardized data definitions with the ultimate goal of monitoring, comparing, and contrasting national cardiovascular care and its outcomes. One of the first working groups to be established was tasked with identifying and then defining...
Source: Canadian Journal of Cardiology - February 28, 2016 Category: Cardiology Source Type: research

Left Atrial Appendage Closure for Atrial Fibrillation Is Safe and Effective After Intracranial or Intraocular Hemorrhage
Conclusions In our consecutive series, LAA closure was found to be safe and effective in patients with AF and a history of ICH or IOH.
Source: Canadian Journal of Cardiology - February 25, 2016 Category: Cardiology Source Type: research

Net Clinical Benefit of Dabigatran over Warfarin in Patients with Atrial Fibrillation Stratified by CHA2DS2-VASc Score and Time in Therapeutic Range
Conclusion The combination of CHA2DS2-VASc score and TTR facilitates patient prioritization for dabigatran. The best net clinical benefit for switching warfarin to dabigatran was found in those with both high CHA2DS2-VASc score and poor TTR. Teaser Non-vitamin K antagonist oral anticoagulants (NOAC) are now preferred to warfarin for stroke prevention in atrial fibrillation. In this study, we have shown that combination of CHA2DS2-VASc score and time in therapeutic range (TTR) facilitates patient prioritization for Dabigatran – one of the NOACs. The best net clinical benefit for switching from Dabigatran to warfarin was o...
Source: Canadian Journal of Cardiology - January 26, 2016 Category: Cardiology Source Type: research

Time in Therapeutic Range and Percentage of INRs in Therapeutic Range as measure of quality of anticoagulation control in atrial fibrillation patients
Conclusions Amongst AF patients on warfarin, the PINRR is a user-friendly alternative to TTR, having a high sensitivity and positive predictive value in predicting TTR. As with TTRs, PINRR is associated with clinical adverse events, i.e. ischemic stroke and intracranial hemorrhage.
Source: Canadian Journal of Cardiology - November 6, 2015 Category: Cardiology Source Type: research

Left Atrial Appendage Closure for Atrial Fibrillation is Safe and Effective Following Intracranial or Intraocular Hemorrhage
Conclusion In our consecutive series, LAA closure was found to be safe and effective in patients with AF and prior history of ICH or IOH. Teaser Long-term anticoagulation may be avoided in patients with non-valvular AF and previous intra-cranial (ICH) or intra-ocular (IOH) hemorrhage after LAA closure. We report our consecutive series of 26 patients with previous ICH/IOH who underwent LAA closure. At 11.9 ± 13.3 months follow-up, there was one non-cardiac death at 13 months, one TIA at 20.6 months, and no major bleed. Thus, LAA closure was safe and effective in AF patients and prior history of ICH/IOH.
Source: Canadian Journal of Cardiology - August 12, 2015 Category: Cardiology Source Type: research

The case against using hypertension as the only criterion for oral anticoagulation in atrial fibrillation
Publication date: Available online 24 March 2015 Source:Canadian Journal of Cardiology Author(s): Simon W. Rabkin , Gordon Moe According to recent guidelines for atrial fibrillation (AF) management, the presence of hypertension warrants anticoagulation, often involving the use of newer oral anticoagulants (NOACs). To discuss this idea, we posited the case against this proposition. We note that the data on hypertension that formulated the most commonly used (CHADS2) risk algorithm were not clearly defined and there is insufficient data that hypertension in the presence of AF produces a meaningful incremental increase in s...
Source: Canadian Journal of Cardiology - March 25, 2015 Category: Cardiology Source Type: research