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Source: The Journal of Alzheimers Association
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Total 90 results found since Jan 2013.
Risk factors for dementia in older intensive care unit (ICU) survivors
DISCUSSION: Future studies will need to examine whether interventions targeting post-ICU stroke and depression can lower dementia incidence in ICU survivors.HIGHLIGHTS: Risk factors for post-intensive care unit (ICU) dementia were distinct from those of Alzheimer's disease. Cardiovascular risk factors were not associated with dementia in older ICU survivors. Post-ICU stroke was associated with a higher risk of dementia in older ICU survivors. Post-ICU depression was associated with a higher risk of dementia in older ICU survivors.PMID:37589315 | DOI:10.1002/alz.13423
Source: The Journal of Alzheimers Association - August 17, 2023 Category: Psychiatry Authors: Sophia Wang Anthony J Perkins Rosalyn Chi Brandon A Yates Sikandar H Khan Sujuan Gao Malaz Boustani Babar A Khan Source Type: research
Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA
DISCUSSION: Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.PMID:37289978 | DOI:10.1002/alz.13346
Source: The Journal of Alzheimers Association - June 8, 2023 Category: Psychiatry Authors: Paul N Jensen Tanweer Rashid Jeffrey B Ware Yuhan Cui Colleen M Sitlani Thomas R Austin W T Longstreth Alain G Bertoni Elizabeth Mamourian R Nick Bryan Ilya M Nasrallah Mohamad Habes Susan R Heckbert Source Type: research
Preanalytical stability of plasma/serum brain-derived tau
DISCUSSION: BD-tau has equivalent diagnostic accuracies, but non-interchangeable absolute concentrations, in plasma versus serum. Furthermore, the analytical robustness is unaffected by batch-to-batch reagent variations.HIGHLIGHTS: Brain-derived tau (BD-tau) is a novel blood-based biomarker that quantifies tau protein of CNS origin. Effects of preanalytical handling procedures on the quality and reproducibility of BD-tau measures are unknown. In two cohorts of n = 105 participants, we compared BD-tau concentrations and diagnostic performances in paired plasma and serum samples, and evaluated impacts of batch-to-batch reage...
Source: The Journal of Alzheimers Association - May 26, 2023 Category: Psychiatry Authors: Fernando Gonzalez-Ortiz Alexandre Dias Michael Turton Rui Magalh ães Przemys ław R Kac Manuel Correia Peter Harrison Henrik Zetterberg Lu ís F Maia Kaj Blennow Thomas K Karikari Source Type: research
Brain health and mental health: Common vascular risk factors and practical implications
Alzheimers Dement. 2023 May 22. doi: 10.1002/alz.13153. Online ahead of print.ABSTRACTThe pandemic dramatized the close links among cognitive, mental, and social health; a change in one reflects others. This realization offers the opportunity to bridge the artificial separation of brain and mental health, as brain disorders have behavioral consequences and behavioral disorders affect the brain. The leading causes of mortality and disability, namely stroke, heart disease, and dementia, share the same risk and protective factors. It is emerging that bipolar disorders, obsessive compulsive disorders, and some depressions shar...
Source: The Journal of Alzheimers Association - May 22, 2023 Category: Psychiatry Authors: Vladimir Hachinski Ennapadam Krishnamoorthy Levent Kuey Laurence J Kirmayer Source Type: research
Prevalent stroke, age of its onset, and post-stroke lifestyle in relation to dementia: A prospective cohort study
DISCUSSION: Stroke onset in earlier life stage predicted a higher risk for dementia, but a favorable post-stroke lifestyle may protect against dementia.PMID:37157186 | DOI:10.1002/alz.13122
Source: The Journal of Alzheimers Association - May 9, 2023 Category: Psychiatry Authors: Wansi Zhong Hui Chen Xiaoxian Gong Lusha Tong Xin Xu Geng Zong Changzheng Yuan Min Lou Source Type: research
Comparison of genetic and health risk factors for mild cognitive impairment and Alzheimer's disease between Hispanic and non-Hispanic white participants
DISCUSSION: APOEε2 may not be protective for AD in Hispanic participants and Hispanic participants with depression may face a higher risk for AD.HIGHLIGHTS: GAAIN allows for discovery of data sets to use in secondary analyses. APOEε2 was not protective for AD in Hispanic participants. APOEε4 was associated with fewer MCI cases in Hispanic participants. Depression was associated with more AD cases in Hispanic participants.PMID:37104247 | DOI:10.1002/alz.13110
Source: The Journal of Alzheimers Association - April 27, 2023 Category: Psychiatry Authors: Cally Xiao Ioannis Pappas Leon M Aksman Sid E O'Bryant Arthur W Toga Health and Aging Brain Study (HABS-HD) Study Team, Alzheimer's Disease Neuroimaging Initiative Source Type: research
2023 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease, including prevalence and incidence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society. The Special Report examines the patient journey from awareness of cognitive changes to potential treatment with drugs that change the underlying biology of Alzheimer's. An estimated 6.7 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060 barring the development of medical breakthroughs to prevent, slow or cure AD. Off...
Source: The Journal of Alzheimers Association - March 15, 2023 Category: Psychiatry Source Type: research
Cognitive trajectories and incident dementia after a cardiovascular event in older adults
DISCUSSION: Findings highlight the importance of monitoring cognition after a CVD event.PMID:36856152 | DOI:10.1002/alz.13006
Source: The Journal of Alzheimers Association - March 1, 2023 Category: Psychiatry Authors: Swarna Vishwanath Ingrid Hopper Rory Wolfe Galina Polekhina Christopher M Reid Andrew M Tonkin Anne M Murray Raj C Shah Elsdon Storey Robyn L Woods John McNeil Suzanne G Orchard Mark R Nelson Claire J Steves Joanne Ryan Source Type: research
High cholesterol levels change the association of biomarkers of neurodegenerative diseases with dementia risk: Findings from a population-based cohort
This study assessed whether in a population with comorbidity of neurodegenerative and cerebrovascular disease (mixed pathology) the association of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181) with dementia risk varied depending on levels of total cholesterol and apolipoprotein E (APOE) ε4 genotype.METHODS: Plasma biomarkers were measured using Simoa technology in 768 participants of a nested case-control study embedded within an ongoing population-based cohort. Logistic and spline regression models, and receiver operating characteristic curves were calculate...
Source: The Journal of Alzheimers Association - January 13, 2023 Category: Psychiatry Authors: Laura Perna Ute Mons Hannah Stocker L éon Beyer Konrad Beyreuther Kira Trares Bernd Holleczek Ben Sch öttker Robert Perneczky Klaus Gerwert Hermann Brenner Source Type: research
