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Comparison of Carotid Plaque Score and Coronary Artery Calcium Score for Predicting Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology
BackgroundCoronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown.Methods and ResultsCVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound‐detected plaques in the common, bifurcation, and internal carotid artery segments. CAC was detected by computed tomography. Predictive ...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Gepner, A. D., Young, R., Delaney, J. A., Budoff, M. J., Polak, J. F., Blaha, M. J., Post, W. S., Michos, E. D., Kaufman, J., Stein, J. H. Tags: Epidemiology, Primary Prevention, Risk Factors, Computerized Tomography (CT), Magnetic Resonance Imaging (MRI) Original Research Source Type: research

Cerebral Microbleeds, Vascular Risk Factors, and Magnetic Resonance Imaging Markers: The Northern Manhattan Study Epidemiology
Conclusions CMBs may represent the severity of vascular disease in this racially and ethnically diverse cohort. Larger studies are needed to elucidate the association between diabetes medication use and CMB presence.
Source: JAHA:Journal of the American Heart Association - September 15, 2016 Category: Cardiology Authors: Caunca, M. R., Del Brutto, V., Gardener, H., Shah, N., Dequatre-Ponchelle, N., Cheung, Y. K., Elkind, M. S. V., Brown, T. R., Cordonnier, C., Sacco, R. L., Wright, C. B. Tags: Epidemiology, Race and Ethnicity Source Type: research

Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis Stroke
Conclusions Intracranial plaque enhancement on high-resolution vessel wall MRI is strongly associated with ischemic stroke. Evaluation for plaque enhancement on MRI may be a useful test to improve diagnostic yield in patients with ischemic strokes of undetermined etiology.
Source: JAHA:Journal of the American Heart Association - August 14, 2016 Category: Cardiology Authors: Gupta, A., Baradaran, H., Al-Dasuqi, K., Knight-Greenfield, A., Giambrone, A. E., Delgado, D., Wright, D., Teng, Z., Min, J. K., Navi, B. B., Iadecola, C., Kamel, H. Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke, Atherosclerosis Source Type: research

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study Epidemiology
Conclusions Cumulative vascular risk factor exposure may increase the risk of CMB, especially in deep regions. The apparent paradoxical association of carotid intima–media thickness progression with lower risk of CMB may reflect benefits of intensive vascular risk factor treatment among persons with higher cardiovascular risk and deserves further investigation. If replicated, the results may have potential implications for assessment of preventive and therapeutic interventions for subclinical cerebral hemorrhage.
Source: JAHA:Journal of the American Heart Association - March 17, 2016 Category: Cardiology Authors: Romero, J. R., Preis, S. R., Beiser, A., DeCarli, C., D'Agostino, R. B., Wolf, P. A., Vasan, R. S., Polak, J. F., Seshadri, S. Tags: Epidemiology, Magnetic Resonance Imaging (MRI), Ultrasound, Cerebrovascular Disease/Stroke, Atherosclerosis Source Type: research

Neuropsychological Status and Structural Brain Imaging in Adolescents With Single Ventricle Who Underwent the Fontan Procedure Congenital Heart Disease
Conclusions The neuropsychological deficits and high frequencies of structural brain abnormalities in adolescents who underwent the Fontan procedure highlight the need for research on interventions to improve the long-term outcomes in this high-risk group.
Source: JAHA:Journal of the American Heart Association - December 14, 2015 Category: Cardiology Authors: Bellinger, D. C., Watson, C. G., Rivkin, M. J., Robertson, R. L., Roberts, A. E., Stopp, C., Dunbar-Masterson, C., Bernson, D., DeMaso, D. R., Wypij, D., Newburger, J. W. Tags: Congenital Heart Disease Source Type: research

N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives Imaging
Conclusions N-glycome levels might be potentially useful as biomarkers for the presence of silent cerebrovascular disease.
Source: JAHA:Journal of the American Heart Association - November 23, 2015 Category: Cardiology Authors: Vilar-Bergua, A., Riba-Llena, I., Vanhooren, V., Dewaele, S., Libert, C., Penalba, A., Montaner, J., Delgado, P. Tags: Imaging Source Type: research

Brain Arterial Diameters as a Risk Factor for Vascular Events Epidemiology
Conclusions The risk of death, vascular death, and any vascular event increased at both extremes of brain arterial diameters. The pathophysiology linking brain arterial remodeling to systemic vascular events needs further research.
Source: JAHA:Journal of the American Heart Association - August 6, 2015 Category: Cardiology Authors: Gutierrez, J., Cheung, K., Bagci, A., Rundek, T., Alperin, N., Sacco, R. L., Wright, C. B., Elkind, M. S. V. Tags: Epidemiology Source Type: research

Resistive and Pulsatile Arterial Hemodynamics and Cardiovascular Events: The Multiethnic Study of Atherosclerosis Heart Failure
Conclusions Greater total arterial compliance, manifest by higher stroke volume/pulse pressure is associated with a reduced incidence of subsequent CVE. In contrast, SVR was not independently associated with CVE in subjects free of overt cardiovascular disease at baseline. These findings support the concept that alternations in the large conduit vessels, rather than changes in microvascular resistance, are primarily related to incident cardiovascular disease.
Source: JAHA:Journal of the American Heart Association - December 11, 2014 Category: Cardiology Authors: Lilly, S. M., Jacobs, D., Bluemke, D. A., Duprez, D., Zamani, P., Chirinos, J. Tags: Heart Failure Source Type: research

Prognostic Implications of Left Ventricular Dyssynchrony for Major Adverse Cardiovascular Events in Asymptomatic Women and Men: The Multi-Ethnic Study of Atherosclerosis Heart Failure
Conclusions In an asymptomatic cohort, greater LV dyssynchrony determined by cardiac magnetic resonance imaging predicts adverse cardiovascular outcome in women but not in men. Clinical Trial Registration URL: http://clinicaltrials.gov. Unique identifier: NCT00005487.
Source: JAHA:Journal of the American Heart Association - August 4, 2014 Category: Cardiology Authors: Sharma, R. K., Volpe, G., Rosen, B. D., Ambale-Venkatesh, B., Donekal, S., Fernandes, V., Wu, C. O., Carr, J., Bluemke, D. A., Lima, J. A. C. Tags: Heart Failure Source Type: research

Circulating Omega-3 Polyunsaturated Fatty Acids and Subclinical Brain Abnormalities on MRI in Older Adults: The Cardiovascular Health Study Stroke
Conclusions Among older adults, higher phospholipid long-chain omega-3 PUFA content was associated with lower prevalence of subclinical infarcts and better white matter grade on MRI. Our results support the beneficial effects of fish consumption, the major source of long-chain omega-3 PUFAs, on brain health in later life. The role of plant-derived alpha-linolenic acid in brain health requires further investigation.
Source: JAHA:Journal of the American Heart Association - October 10, 2013 Category: Cardiology Authors: Virtanen, J. K., Siscovick, D. S., Lemaitre, R. N., Longstreth, W. T., Spiegelman, D., Rimm, E. B., King, I. B., Mozaffarian, D. Tags: Stroke Source Type: research

Clopidogrel Use Is Associated With an Increased Prevalence of Cerebral Microbleeds in a Stroke-Free Population: The Rotterdam Study Stroke
Conclusions In stroke-free individuals, clopidogrel use was associated with a higher prevalence and higher number of CMBs. Whether this association is causal requires confirmation in prospective studies, especially given the small number of participants taking clopidogrel and the possibility of residual confounding in this study.
Source: JAHA:Journal of the American Heart Association - September 26, 2013 Category: Cardiology Authors: Darweesh, S. K. L., Leening, M. J. G., Akoudad, S., Loth, D. W., Hofman, A., Arfan Ikram, M., Vernooij, M. W., Stricker, B. H. Tags: Stroke Source Type: research

Magnetic Resonance Imaging Profile of Blood-Brain Barrier Injury in Patients With Acute Intracerebral Hemorrhage Stroke
Conclusions BBB leakage in the brain tissue immediately bordering the hematoma can be measured and quantified by DCE MRI in human ICH. BBB leakage at 1 week is greater in larger hematomas as well as in hematomas in lobar locations and is associated with larger edema volumes.
Source: JAHA:Journal of the American Heart Association - May 24, 2013 Category: Cardiology Authors: Aksoy, D., Bammer, R., Mlynash, M., Venkatasubramanian, C., Eyngorn, I., Snider, R. W., Gupta, S. N., Narayana, R., Fischbein, N., Wijman, C. A. C. Tags: Stroke Source Type: research