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Stroke Ready Intervention: Community Engagement to Decrease Prehospital Delay Stroke
Conclusions Stroke Ready increased stroke preparedness, a necessary step toward increasing acute stroke treatment rates. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT01499173.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Skolarus, L. E., Zimmerman, M. A., Bailey, S., Dome, M., Murphy, J. B., Kobrossi, C., Dombrowski, S. U., Burke, J. F., Morgenstern, L. B. Tags: Race and Ethnicity, Cerebrovascular Disease/Stroke Source Type: research

Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial Stroke
Conclusions Age has a greater influence on major bleeding than thromboembolic risk in patients with atrial fibrillation. Given the higher rates of bleeding and death with increasing age, treatment of elderly patients with edoxaban provides an even greater absolute reduction in safety events over warfarin, compared to treatment with edoxaban versus warfarin in younger patients. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00781391.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Kato, E. T., Giugliano, R. P., Ruff, C. T., Koretsune, Y., Yamashita, T., Kiss, R. G., Nordio, F., Murphy, S. A., Kimura, T., Jin, J., Lanz, H., Mercuri, M., Braunwald, E., Antman, E. M. Tags: Atrial Fibrillation, Complications, Mortality/Survival, Intracranial Hemorrhage, Ischemic Stroke Source Type: research

Pacemakers as Atrial Fibrillation Detectors: Finding Racial Differences and Opportunities for Preventing Stroke Correction
Source: JAHA:Journal of the American Heart Association - May 11, 2016 Category: Cardiology Tags: Correction Source Type: research

Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women Epidemiology
Conclusions Women with the highest PTSD symptom levels had nearly a 2-fold increased risk of VTE compared to women without trauma exposure in fully adjusted models. Trauma exposure alone was also associated with elevated VTE risk. Trauma and PTSD symptoms may be associated with a hypercoagulable state. Treatment providers should be aware that women with trauma exposure and PTSD symptoms may be vulnerable to VTE.
Source: JAHA:Journal of the American Heart Association - May 11, 2016 Category: Cardiology Authors: Sumner, J. A., Kubzansky, L. D., Kabrhel, C., Roberts, A. L., Chen, Q., Winning, A., Gilsanz, P., Rimm, E. B., Glymour, M. M., Koenen, K. C. Tags: Epidemiology, Mental Health, Women Source Type: research

Increasing Incidence of Hospitalization for Stroke and Transient Ischemic Attack in Young Adults: A Registry-Based Study Stroke
Conclusions The incidence rates of first-time hospitalizations for ischemic stroke and TIA in young Danish adults have increased substantially since the mid 1990s. The increase was particularly prominent in the most recent years.
Source: JAHA:Journal of the American Heart Association - May 10, 2016 Category: Cardiology Authors: Tibaek, M., Dehlendorff, C., Jorgensen, H. S., Forchhammer, H. B., Johnsen, S. P., Kammersgaard, L. P. Tags: Epidemiology, Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Source Type: research

Trends in Acute Ischemic Stroke Hospitalizations in the United States Stroke
Conclusions Although overall stroke hospitalizations declined in the United States, the reduction was more pronounced among older individuals, women, Hispanics, and whites. Renewed efforts at targeting risk factor control among vulnerable individuals may be warranted.
Source: JAHA:Journal of the American Heart Association - May 10, 2016 Category: Cardiology Authors: Ramirez, L., Kim-Tenser, M. A., Sanossian, N., Cen, S., Wen, G., He, S., Mack, W. J., Towfighi, A. Tags: Cardiovascular Disease, Cerebrovascular Disease/Stroke, Ischemic Stroke Source Type: research

Rising Stroke Incidence in Young Adults: More Epidemiological Evidence, More Questions to Be Answered Editorial
Source: JAHA:Journal of the American Heart Association - May 10, 2016 Category: Cardiology Authors: Bejot, Y., Delpont, B., Giroud, M. Tags: Epidemiology, Cerebrovascular Disease/Stroke Editorial Source Type: research

Field Synopsis of the Role of Sex in Stroke Prediction Models Health Services and Outcomes Research
Conclusions Sex is included in a minority of published CPMs, but more frequently in models predicting incidence of first stroke. The importance of sex-specific care may be especially well established for primary prevention.
Source: JAHA:Journal of the American Heart Association - May 4, 2016 Category: Cardiology Authors: Paulus, J. K., Lai, L. Y. H., Lundquist, C., Daneshmand, A., Buettner, H., Lutz, J. S., Raman, G., Wessler, B. S., Kent, D. M. Tags: Primary Prevention, Risk Factors, Secondary Prevention, Women, Health Services Health Services and Outcomes Research Source Type: research

Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry Health Services and Outcomes Research
Conclusions In a contemporary AF cohort, use of OAC overall and use of NOACs were not significantly lower among Medicaid patients relative to others. However, among warfarin users, Medicaid patients spent less time in therapeutic range compared with those with other forms of insurance.
Source: JAHA:Journal of the American Heart Association - May 3, 2016 Category: Cardiology Authors: O'Brien, E. C., Kim, S., Thomas, L., Fonarow, G. C., Kowey, P. R., Mahaffey, K. W., Gersh, B. J., Piccini, J. P., Peterson, E. D. Tags: Atrial Fibrillation, Primary Prevention, Health Services, Quality and Outcomes Health Services and Outcomes Research Source Type: research

Prehospital Phase of the Stroke Chain of Survival: A Prospective Observational Study Stroke
Conclusions Fast emergency medical services activation and ambulance transport promoted early hospital arrival and treatment. Although patient-dependent delays still dominate the prehospital process, it should be ensured that the minutes on the scene are well spent.
Source: JAHA:Journal of the American Heart Association - May 1, 2016 Category: Cardiology Authors: Puolakka, T., Strbian, D., Harve, H., Kuisma, M., Lindsberg, P. J. Tags: Stroke Source Type: research

Association of Thoracic Aorta Calcium Score With Exercise Blood Pressure Response and Clinical Outcomes in Elderly Individuals: Differential Impact of Aorta Calcification Compared With Coronary Artery Calcification Preventive Cardiology
Conclusions Aortic calcification was related to SBP response during exercise and was an independent predictor for outcomes, especially stroke, regardless of resting SBP or CACS.
Source: JAHA:Journal of the American Heart Association - April 21, 2016 Category: Cardiology Authors: Cho, I.-J., Chang, H.-J., Cho, I., Heo, R., Lee, S.-E., Shim, C. Y., Hong, G.-R., Chung, N. Tags: Computerized Tomography (CT) Preventive Cardiology Source Type: research

Comparative Effectiveness of Generic Atorvastatin and Lipitor(R) in Patients Hospitalized with an Acute Coronary Syndrome Health Services and Outcomes Research
Conclusions Among older adults discharged alive after ACS hospitalization, we found no significant difference in cardiovascular outcomes or serious, infrequent side effects in patients prescribed generic atorvastatin compared with those prescribed Lipitor® at 1 year. Our findings support the use of generic atorvastatin in ACS, which could lead to substantial cost saving for patients and health care plans without diminishing population clinical effectiveness.
Source: JAHA:Journal of the American Heart Association - April 18, 2016 Category: Cardiology Authors: Jackevicius, C. A., Tu, J. V., Krumholz, H. M., Austin, P. C., Ross, J. S., Stukel, T. A., Koh, M., Chong, A., Ko, D. T. Tags: Atrial Fibrillation, Quality and Outcomes Health Services and Outcomes Research Source Type: research

Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis Valvular Heart Disease
Conclusions Six-month mortality after IE is 25% and is predicted by host factors, IE characteristics, and IE complications. Surgery during the index hospitalization is associated with lower mortality but is performed less frequently in the highest risk patients. A simplified risk model may be used to identify specific risk subgroups in IE.
Source: JAHA:Journal of the American Heart Association - April 17, 2016 Category: Cardiology Authors: Park, L. P., Chu, V. H., Peterson, G., Skoutelis, A., Lejko-Zupa, T., Bouza, E., Tattevin, P., Habib, G., Tan, R., Gonzalez, J., Altclas, J., Edathodu, J., Fortes, C. Q., Siciliano, R. F., Pachirat, O., Kanj, S., Wang, A., for the International Collaborat Tags: Clinical Studies, Infectious Endocarditis, Valvular Heart Disease, Mortality/Survival Source Type: research

Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain Coronary Heart Disease
Conclusion Low plasma homoarginine was identified as a risk marker for incident MACEs in patients with acute chest pain, in particular, in those with elevated hsTnI. Impaired homoarginine was associated with prevalent AF. Further studies are needed to investigate the link to AF and evaluate homoarginine as a therapeutic option for these patients.
Source: JAHA:Journal of the American Heart Association - April 12, 2016 Category: Cardiology Authors: Atzler, D., Baum, C., Ojeda, F., Keller, T., Cordts, K., Schnabel, R. B., Choe, C.-u., Lackner, K. J., Münzel, T., Böger, R. H., Blankenberg, S., Schwedhelm, E., Zeller, T. Tags: Atrial Fibrillation, Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Acute Coronary Syndromes Coronary Heart Disease Source Type: research

Ischemic Stroke or Systemic Embolism After Transseptal Ablation of Arrhythmias in Patients With Cardiac Implantable Electronic Devices Arrhythmia and Electrophysiology
Conclusion CIEDs are associated with an increased risk of stroke, TIA, or systemic embolism after transseptal ablation, but this risk is attenuated with postablation OAC use. Role of anticoagulation post-transseptal ablation in patients with CIED warrants further investigation.
Source: JAHA:Journal of the American Heart Association - April 12, 2016 Category: Cardiology Authors: Madhavan, M., Yao, X., Sangaralingham, L. R., Asirvatham, S. J., Friedman, P. A., McLeod, C. J., Sugrue, A. M., DeSimone, C. V., Noseworthy, P. A. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation, Ischemic Stroke, Transient Ischemic Attack (TIA) Arrhythmia and Electrophysiology Source Type: research

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