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Beta-Blocker Use Is Associated With Impaired Left Atrial Function in Hypertension Hypertension
BackgroundImpaired left atrial (LA) mechanical function is present in hypertension and likely contributes to various complications, including atrial arrhythmias, stroke, and heart failure. Various antihypertensive drug classes exert differential effects on central hemodynamics and left ventricular function. However, little is known about their effects on LA function.Methods and ResultsWe studied 212 subjects with hypertension and without heart failure or atrial fibrillation. LA strain was measured from cine steady‐state free‐precession cardiac MRI images using feature‐tracking algorithms. In multivariable models adju...
Source: JAHA:Journal of the American Heart Association - February 3, 2017 Category: Cardiology Authors: Sardana, M., Syed, A. A., Hashmath, Z., Phan, T. S., Koppula, M. R., Kewan, U., Ahmed, Z., Chandamuri, R., Varakantam, S., Shah, E., Gorz, R., Akers, S. R., Chirinos, J. A. Tags: Atrial Fibrillation, Hypertension, Magnetic Resonance Imaging (MRI) Original Research Source Type: research

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study Epidemiology
Conclusions Cumulative vascular risk factor exposure may increase the risk of CMB, especially in deep regions. The apparent paradoxical association of carotid intima–media thickness progression with lower risk of CMB may reflect benefits of intensive vascular risk factor treatment among persons with higher cardiovascular risk and deserves further investigation. If replicated, the results may have potential implications for assessment of preventive and therapeutic interventions for subclinical cerebral hemorrhage.
Source: JAHA:Journal of the American Heart Association - March 17, 2016 Category: Cardiology Authors: Romero, J. R., Preis, S. R., Beiser, A., DeCarli, C., D'Agostino, R. B., Wolf, P. A., Vasan, R. S., Polak, J. F., Seshadri, S. Tags: Epidemiology, Magnetic Resonance Imaging (MRI), Ultrasound, Cerebrovascular Disease/Stroke, Atherosclerosis Source Type: research

Leukoaraiosis and Increased Cerebral Susceptibility to Ischemia: Lack of Confounding by Carotid Disease Stroke
Conclusions The association with more severe ischemic events (stroke versus TIA) and infarction on imaging is consistent with leukoaraiosis being a marker of increased cerebral susceptibility to ischemia. In contrast, the presence, severity of, and risk factors for atheromatous disease showed no association with leukoaraiosis, suggesting that these are two unrelated disease processes.
Source: JAHA:Journal of the American Heart Association - August 20, 2013 Category: Cardiology Authors: Schulz, U. G., Gruter, B. E., Briley, D., Rothwell, P. M. Tags: Stroke Source Type: research