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Systolic Blood Pressure Within 24 Hours After Thrombectomy for Acute Ischemic Stroke Correlates With Outcome Stroke
ConclusionsHigher peak values of systolic blood pressure independently correlated with worse 90‐day modified Rankin scale and a higher rate of hemorrhagic complications. Further prospective studies are warranted to identify whether systolic blood pressure is a therapeutic target to improve outcomes.
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Mistry, E. A., Mistry, A. M., Nakawah, M. O., Khattar, N. K., Fortuny, E. M., Cruz, A. S., Froehler, M. T., Chitale, R. V., James, R. F., Fusco, M. R., Volpi, J. J. Tags: High Blood Pressure, Revascularization, Complications, Quality and Outcomes, Ischemic Stroke Original Research Source Type: research

Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype Stroke
BackgroundIschemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age.Methods and ResultsWe studied a prospective multicenter university hospital–based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or an...
Source: JAHA:Journal of the American Heart Association - May 8, 2017 Category: Cardiology Authors: Hauer, A. J., Ruigrok, Y. M., Algra, A., van Diȷk, E. J., Koudstaal, P. J., Luiȷckx, G.–J., Nederkoorn, P. J., van Oostenbrugge, R. J., Visser, M. C., Wermer, M. J., Kappelle, L. J., Kliȷn, C. J. M., the Dutch Parelsnoer Instit Tags: Risk Factors, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research

Comparative Effectiveness and Safety of Dabigatran and Rivaroxaban in Atrial Fibrillation Patients Arrhythmia and Electrophysiology
ConclusionsRivaroxaban therapy was associated with a statistically significant increase in all‐cause death compared with dabigatran therapy in atrial fibrillation patients.
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Lai, C.-L., Chen, H.-M., Liao, M.-T., Lin, T.-T., Chan, K. A. Tags: Arrhythmias, Anticoagulants, Pharmacology, Cerebrovascular Disease/Stroke Original Research Source Type: research

Incidence of First Stroke in Pregnant and Nonpregnant Women of Childbearing Age: A Population-Based Cohort Study From England Epidemiology
ConclusionsAlthough the absolute risk of first stroke is low in women of childbearing age, healthcare professionals should be aware of a considerable increase in relative risk during the peripartum and early postpartum periods.
Source: JAHA:Journal of the American Heart Association - April 21, 2017 Category: Cardiology Authors: Ban, L., Sprigg, N., Abdul Sultan, A., Nelson-Piercy, C., Bath, P. M., Ludvigsson, J. F., Stephansson, O., Tata, L. J. Tags: Epidemiology, Pregnancy, Women, Cerebrovascular Disease/Stroke Original Research Source Type: research

Time in Therapeutic Range and Outcomes After Warfarin Initiation in Newly Diagnosed Atrial Fibrillation Patients With Renal Dysfunction Kidney in Cardiovascular Disease
BackgroundIt is unknown whether renal dysfunction conveys poor anticoagulation control in warfarin‐treated patients with atrial fibrillation and whether poor anticoagulation control associates with the risk of adverse outcomes in these patients.Methods and ResultsThis was an observational study from the Stockholm CREatinine Measurements (SCREAM) cohort including all newly diagnosed atrial fibrillation patients initiating treatment with warfarin (n=7738) in Stockholm, Sweden, between 2006 and 2011. Estimated glomerular filtration rate (eGFR; mL/min per 1.73 m2) was calculated from serum creatinine. Time‐in‐therapeuti...
Source: JAHA:Journal of the American Heart Association - March 1, 2017 Category: Cardiology Authors: Szummer, K., Gasparini, A., Eliasson, S., Arnlov, J., Qureshi, A. R., Barany, P., Evans, M., Friberg, L., Carrero, J. J. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Cardiovascular Disease, Anticoagulants, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research

Interleukin-23 Secreted by Activated Macrophages Drives {gamma}{delta}T Cell Production of Interleukin-17 to Aggravate Secondary Inȷury After Intracerebral Hemorrhage Stroke
ConclusionsTogether, our results reveal the importance of the IL‐23/IL‐17 inflammatory axis in secondary brain injury after ICH and thus provide a new therapeutic target for ICH treatment.
Source: JAHA:Journal of the American Heart Association - October 10, 2016 Category: Cardiology Authors: Zhong, Q., Zhou, K., Liang, Q.-L., Lin, S., Wang, Y.-C., Xiong, X.-Y., Meng, Z.-Y., Zhao, T., Zhu, W.-Y., Yang, Y.-R., Liao, M.-F., Gong, Q.-W., Liu, L., Xiong, A., Hao, J., Wang, J., Yang, Q.-W. Tags: Blood-Brain Barrier, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Research Source Type: research

Impact of Blood Pressure Control on Thromboembolism and Maȷor Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J-RHYTHM Registry Arrhythmia and Electrophysiology
BackgroundTo clarify the influence of hypertension and blood pressure (BP) control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed.Methods and ResultsA consecutive series of outpatients with atrial fibrillation was enrolled from 158 institutions. Of 7937 patients, 7406 with nonvalvular atrial fibrillation (70.8% men, 69.8±10.0 years) were followed for 2 years or until an event occurred. Hypertension was defined as a systolic BP ≥140 mm Hg, a diastolic BP ≥90 mm Hg, a history of hypertension, and/or antihyperten...
Source: JAHA:Journal of the American Heart Association - September 11, 2016 Category: Cardiology Authors: Kodani, E., Atarashi, H., Inoue, H., Okumura, K., Yamashita, T., Otsuka, T., Tomita, H., Origasa, H. Tags: Atrial Fibrillation, High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research

Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J-RHYTHM Registry Arrhythmia and Electrophysiology
Conclusions BP control appears to be more important than a history of hypertension and baseline BP values at preventing thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation. Clinical Trial Registration URL: http://www.umin.ac.jp/ctr. Unique identifier: UMIN000001569.
Source: JAHA:Journal of the American Heart Association - September 11, 2016 Category: Cardiology Authors: Kodani, E., Atarashi, H., Inoue, H., Okumura, K., Yamashita, T., Otsuka, T., Tomita, H., Origasa, H., the J-RHYTHM Registry Investigators Tags: Atrial Fibrillation, High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Impact of Hemoglobin Levels and Anemia on Mortality in Acute Stroke: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis Stroke
ConclusionsStrong evidence suggests that patients with anemia have increased mortality with stroke. Targeted interventions in this patient population may improve outcomes and require further evaluation.
Source: JAHA:Journal of the American Heart Association - August 16, 2016 Category: Cardiology Authors: Barlas, R. S., Honney, K., Loke, Y. K., McCall, S. J., Bettencourt-Silva, J. H., Clark, A. B., Bowles, K. M., Metcalf, A. K., Mamas, M. A., Potter, J. F., Myint, P. K. Tags: Epidemiology, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research

Race-Specific Predictors of Mortality in Intracerebral Hemorrhage: Differential Impacts of Intraventricular Hemorrhage and Age Among Blacks and Whites Stroke
Conclusions IVH and age differentially predict mortality among blacks and whites. Blacks have higher rates of obstructive hydrocephalus and more frequently require EVD placement compared to their white counterparts.
Source: JAHA:Journal of the American Heart Association - August 15, 2016 Category: Cardiology Authors: Faigle, R., Marsh, E. B., Llinas, R. H., Urrutia, V. C., Gottesman, R. F. Tags: Intracranial Hemorrhage Stroke Source Type: research

Particulate Matter and Hospital Admissions for Stroke in Beijing, China: Modification Effects by Ambient Temperature Stroke
Conclusions This study suggests that the associations of PM2.5, PM2.5–10, and PM10 with stroke admissions differed across levels of temperature. Short-term exposure to PM2.5, PM2.5–10, and PM10 was positively associated with hospital admissions for ischemic and hemorrhagic stroke on warm days (>13.5°C).
Source: JAHA:Journal of the American Heart Association - July 12, 2016 Category: Cardiology Authors: Huang, F., Luo, Y., Guo, Y., Tao, L., Xu, Q., Wang, C., Wang, A., Li, X., Guo, J., Yan, A., Guo, X. Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Source Type: research

Accuracy of ICD-9-CM Codes by Hospital Characteristics and Stroke Severity: Paul Coverdell National Acute Stroke Program Health Services and Outcomes Research
Conclusions We identified disagreements in stroke/TIA coding by hospital characteristics and stroke severity, particularly for milder ischemic strokes. Such systematic variations in ICD-9-CM coding practices can affect stroke case identification in epidemiological studies and may have implications for hospital-level quality metrics.
Source: JAHA:Journal of the American Heart Association - May 30, 2016 Category: Cardiology Authors: Chang, T. E., Lichtman, J. H., Goldstein, L. B., George, M. G. Tags: Health Services, Quality and Outcomes Health Services and Outcomes Research Source Type: research

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