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Long-Term Antiplatelet Mono- and Dual Therapies After Ischemic Stroke or Transient Ischemic Attack: Network Meta-Analysis Stroke
Conclusions Long-term monotherapy was a better choice than long-term dual therapy, and cilostazol had the best risk–benefit profile for long-term secondary prevention after stroke or transient ischemic attack. More randomized controlled trials in non–East Asian patients are needed to determine whether long-term use of cilostazol is the best option for the prevention of recurrent stroke.
Source: JAHA:Journal of the American Heart Association - August 24, 2015 Category: Cardiology Authors: Xie, W., Zheng, F., Zhong, B., Song, X. Tags: Stroke Source Type: research

Racial/Ethnic and Sex Differences in Emergency Medical Services Transport Among Hospitalized US Stroke Patients: Analysis of the National Get With The Guidelines-Stroke Registry Stroke
Conclusions EMS use differed by race/ethnicity and sex. These contemporary data document suboptimal use of EMS transport among US stroke patients, especially by racial/ethnic minorities and those with less recognized stroke symptoms.
Source: JAHA:Journal of the American Heart Association - August 12, 2015 Category: Cardiology Authors: Mochari-Greenberger, H., Xian, Y., Hellkamp, A. S., Schulte, P. J., Bhatt, D. L., Fonarow, G. C., Saver, J. L., Reeves, M. J., Schwamm, L. H., Smith, E. E. Tags: Stroke Source Type: research

Brain Arterial Diameters as a Risk Factor for Vascular Events Epidemiology
Conclusions The risk of death, vascular death, and any vascular event increased at both extremes of brain arterial diameters. The pathophysiology linking brain arterial remodeling to systemic vascular events needs further research.
Source: JAHA:Journal of the American Heart Association - August 6, 2015 Category: Cardiology Authors: Gutierrez, J., Cheung, K., Bagci, A., Rundek, T., Alperin, N., Sacco, R. L., Wright, C. B., Elkind, M. S. V. Tags: Epidemiology Source Type: research

Association of 6-Minute Walk Performance and Physical Activity With Incident Ischemic Heart Disease Events and Stroke in Peripheral Artery Disease Vascular Medicine
Conclusions Six-minute walk and physical activity predict IHD event rates in PAD. Further study is needed to determine whether interventions that improve 6-minute walk, physical activity, or both can reduce IHD events in PAD.
Source: JAHA:Journal of the American Heart Association - July 28, 2015 Category: Cardiology Authors: McDermott, M. M., Greenland, P., Tian, L., Kibbe, M. R., Green, D., Zhao, L., Criqui, M. H., Guralnik, J. M., Ferrucci, L., Liu, K., Wilkins, J. T., Huffman, M. D., Shah, S. J., Liao, Y., Lloyd-Jones, D. M. Tags: Vascular Medicine Source Type: research

Perception Versus Actual Performance in Timely Tissue Plasminogen Activation Administration in the Management of Acute Ischemic Stroke Stroke
Conclusions Hospitals often overestimate their ability to deliver timely tPA to treated patients. Our findings indicate the need to routinely provide comparative provider performance rates as a key step to improving the quality of acute stroke care.
Source: JAHA:Journal of the American Heart Association - July 22, 2015 Category: Cardiology Authors: Lin, C. B., Cox, M., Olson, D. M., Britz, G. W., Constable, M., Fonarow, G. C., Schwamm, L., Peterson, E. D., Shah, B. R. Tags: Stroke Source Type: research

Sex Disparities in Stroke: Women Have More Severe Strokes but Better Survival Than Men Stroke
Conclusions Stroke affects women and men differently. Elderly women were affected more severely than elderly men but were more likely to survive.
Source: JAHA:Journal of the American Heart Association - July 6, 2015 Category: Cardiology Authors: Dehlendorff, C., Andersen, K. K., Olsen, T. S. Tags: Stroke Source Type: research

Meta-Analysis of Intracranial Hemorrhage in Acute Coronary Syndromes: Incidence, Predictors, and Clinical Outcomes Coronary Heart Disease
Conclusions In patients with NSTE ACS enrolled in recent clinical trials of antithrombotic therapies, ICH was uncommon. Patients with older age, prior transient ischemic attack/stroke, higher systolic blood pressure, or larger number of antithrombotic agents were at increased risk. One-third of patients with ICH died. These data may be useful to trialists and data and safety monitoring committees for trial conduct and monitoring. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifiers: TRACER: NCT00527943, PLATO: NCT00391872, APPRAISE-2: NCT00831441, TRILOGY ACS: NCT00699998.
Source: JAHA:Journal of the American Heart Association - June 18, 2015 Category: Cardiology Authors: Mahaffey, K. W., Hager, R., Wojdyla, D., White, H. D., Armstrong, P. W., Alexander, J. H., Tricoci, P., Lopes, R. D., Ohman, E. M., Roe, M. T., Harrington, R. A., Wallentin, L. Tags: Coronary Heart Disease Source Type: research

Magnetic Resonance Angiography Detection of Abnormal Carotid Artery Plaque in Patients With Cryptogenic Stroke Stroke
Conclusions Our findings suggest that a proportion of strokes classified as cryptogenic may be mechanistically related to complicated, nonhemodynamically significant cervical carotid artery plaque that can easily be detected by routine magnetic resonance imaging/magnetic resonance angiography acute stroke protocols.
Source: JAHA:Journal of the American Heart Association - June 15, 2015 Category: Cardiology Authors: Gupta, A., Gialdini, G., Lerario, M. P., Baradaran, H., Giambrone, A., Navi, B. B., Marshall, R. S., Iadecola, C., Kamel, H. Tags: Stroke Source Type: research

Catheter Ablation of Atrial Fibrillation in U.S. Community Practice--Results From Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Arrhythmia and Electrophysiology
Conclusions In U.S. clinical practice, a minority of patients with AF are managed with catheter ablation. Subsequent to ablation, there were no significant differences in oral anticoagulation use or outcomes, including stroke/non–central nervous system embolism/transient ischemic attack or death. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01165710.
Source: JAHA:Journal of the American Heart Association - May 21, 2015 Category: Cardiology Authors: Holmqvist, F., Simon, D., Steinberg, B. A., Hong, S. J., Kowey, P. R., Reiffel, J. A., Naccarelli, G. V., Chang, P., Gersh, B. J., Peterson, E. D., Piccini, J. P., the ORBIT-AF Investigators Tags: Arrhythmia and Electrophysiology Source Type: research

Race and Ethnicity, Obesity, Metabolic Health, and Risk of Cardiovascular Disease in Postmenopausal Women Epidemiology
Conclusions Metabolic abnormalities appeared to convey more cardiovascular risk among black women.
Source: JAHA:Journal of the American Heart Association - May 20, 2015 Category: Cardiology Authors: Schmiegelow, M. D., Hedlin, H., Mackey, R. H., Martin, L. W., Vitolins, M. Z., Stefanick, M. L., Perez, M. V., Allison, M., Hlatky, M. A. Tags: Epidemiology Source Type: research

Comprehensive Stroke Centers May Be Associated With Improved Survival in Hemorrhagic Stroke Stroke
Conclusions Hemorrhagic stroke patients admitted to CSCs are more likely to receive neurosurgical and endovascular treatments and be alive at 90 days than patients admitted to other hospitals.
Source: JAHA:Journal of the American Heart Association - May 6, 2015 Category: Cardiology Authors: McKinney, J. S., Cheng, J. Q., Rybinnik, I., Kostis, J. B., the Myocardial Infarction Data Acquisition System (MIDAS 22) Study Group Tags: Stroke Source Type: research

Quantitative Tissue-Tracking Cardiac Magnetic Resonance (CMR) of Left Atrial Deformation and the Risk of Stroke in Patients With Atrial Fibrillation Imaging
Conclusions Depressed LA reservoir function assessed by tissue-tracking cardiac magnetic resonance is significantly associated with a prior history of stroke/transient ischemic attack in patients with AF. Our findings suggest that assessment of LA reservoir function can improve the risk stratification of cerebrovascular events in AF patients.
Source: JAHA:Journal of the American Heart Association - April 27, 2015 Category: Cardiology Authors: Inoue, Y. Y., Alissa, A., Khurram, I. M., Fukumoto, K., Habibi, M., Venkatesh, B. A., Zimmerman, S. L., Nazarian, S., Berger, R. D., Calkins, H., Lima, J. A., Ashikaga, H. Tags: Imaging Source Type: research

Implications of the US Cholesterol Guidelines on Eligibility for Statin Therapy in the Community: Comparison of Observed and Predicted Risks in the Framingham Heart Study Offspring Cohort Epidemiology
Conclusions The risk estimator overpredicted ASCVD risk but did so mainly among high-risk participants who would be considered eligible for statin use anyway. Our findings may mitigate concerns regarding the potential impact of miscalibration of the ASCVD estimator in contemporary cohorts.
Source: JAHA:Journal of the American Heart Association - April 17, 2015 Category: Cardiology Authors: Andersson, C., Enserro, D., Larson, M. G., Xanthakis, V., Vasan, R. S. Tags: Epidemiology Source Type: research

Effectiveness and Safety of Dabigatran and Warfarin in Real-World US Patients With Non-Valvular Atrial Fibrillation: A Retrospective Cohort Study Health Services and Outcomes Research
Conclusions Dabigatran could be a safe and potentially more effective alternative to warfarin in patients with atrial fibrillation managed in routine practice settings.
Source: JAHA:Journal of the American Heart Association - April 10, 2015 Category: Cardiology Authors: Lauffenburger, J. C., Farley, J. F., Gehi, A. K., Rhoney, D. H., Brookhart, M. A., Fang, G. Tags: Health Services and Outcomes Research Source Type: research

Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States Coronary Heart Disease
Conclusions In patients with prior MI or PAD who have not had a previous stroke or TIA, vorapaxar added to standard therapy is effective for long-term secondary prevention of thrombotic CV events, while increasing moderate or severe bleeding. Clinical Trial Registration URL: clinicaltrials.gov Unique Identifier: NCT00526474.
Source: JAHA:Journal of the American Heart Association - March 19, 2015 Category: Cardiology Authors: Magnani, G., Bonaca, M. P., Braunwald, E., Dalby, A. J., Fox, K. A. A., Murphy, S. A., Nicolau, J. C., Oude Ophuis, T., Scirica, B. M., Spinar, J., Theroux, P., Morrow, D. A. Tags: Coronary Heart Disease Source Type: research

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