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Is an Oral Anticoagulant Necessary for Young Atrial Fibrillation Patients With a CHA2DS2-VASc Score of 1 (Men) or 2 (Women)? Arrhythmia and Electrophysiology
ConclusionsFor atrial fibrillation patients aged 20 to 49 years with 1 risk factor in addition to sex, non–vitamin K antagonist OACs should be considered for stroke prevention to minimize the risk of a potentially fatal or disabling event.
Source: JAHA:Journal of the American Heart Association - October 3, 2016 Category: Cardiology Authors: Hung, Y., Chao, T.-F., Liu, C.-J., Tuan, T.-C., Lin, Y.-J., Chang, S.-L., Lo, L.-W., Hu, Y.-F., Liao, J.-N., Chung, F.-P., Lin, W.-Y., Lin, W.-S., Cheng, S.-M., Chen, T.-J., Lip, G. Y. H., Chen, S.-A. Tags: Atrial Fibrillation Original Research Source Type: research

Hemodynamic Tandem Intracranial Lesions on Magnetic Resonance Angiography in Patients Undergoing Carotid Endarterectomy Cardiovascular Surgery
ConclusionsIn patients undergoing carotid endarterectomy, a significant number of preoperative TILs demonstrated hemodynamic components, which were reversed postoperatively. The presence of such components was distinctively associated with the postoperative incidence of new ischemic lesions.
Source: JAHA:Journal of the American Heart Association - October 3, 2016 Category: Cardiology Authors: Lee, E.-J., Cho, Y.-P., Lee, S.-H., Lee, J. S., Nam, H. J., Kim, B. J., Kwon, T.-W., Kang, D.-W., Kim, J. S., Kwon, S. U. Tags: Magnetic Resonance Imaging (MRI), Cardiovascular Surgery, Cerebrovascular Disease/Stroke Original Research Source Type: research

Nonsustained Atrial Fibrillation in Ischemic Stroke Patients and Stroke-Free Controls From the Perspective of Stroke Pathophysiology Stroke
BackgroundShort‐lasting (
Source: JAHA:Journal of the American Heart Association - September 29, 2016 Category: Cardiology Authors: Yetim, E., Topcuoglu, M. A., Canpolat, U., Gocmen, R., Oguz, K. K., Ozer, N., Aytemir, K., Arsava, E. M. Tags: Atrial Fibrillation, Pathophysiology, Electrocardiology (ECG), Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Research Source Type: research

Left Atrial Appendage Closure Under Intracardiac Echocardiographic Guidance: Feasibility and Comparison With Transesophageal Echocardiography Interventional Cardiology
ConclusionsTranscatheter left atrial appendage closure with intracardiac echocardiography guidance is safe and feasible.
Source: JAHA:Journal of the American Heart Association - September 27, 2016 Category: Cardiology Authors: Matsuo, Y., Neuzil, P., Petru, J., Chovanec, M., Janotka, M., Choudry, S., Skoda, J., Sediva, L., Kurabayashi, M., Reddy, V. Y. Tags: Atrial Fibrillation, Imaging, Ischemic Stroke, Thrombosis Original Research Source Type: research

Detection of Atrial Fibrillation Among Patients With Stroke Due to Large or Small Vessel Disease: A Meta-Analysis Stroke
ConclusionsAF detection rate is similar in patients with small and large vessel strokes (2.2–2.4%). Because no studies reported on extended monitoring (>7 days) in these stroke populations, we could not estimate the yield of AF detection with long‐term cardiac monitoring. Randomized controlled trials are needed to examine the utility of AF detection with long‐term cardiac monitoring (>7 days) in this patient population.
Source: JAHA:Journal of the American Heart Association - September 25, 2016 Category: Cardiology Authors: Demeestere, J., Fieuws, S., Lansberg, M. G., Lemmens, R. Tags: Atrial Fibrillation, Secondary Prevention, Anticoagulants, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Research Source Type: research

Trends in Transient Ischemic Attack Hospitalizations in the United States Epidemiology
ConclusionsAlthough overall TIA hospitalizations have decreased in the United States, the reduction has been more pronounced among older individuals, men, whites, and Hispanics. These findings highlight the need to target risk‐factor control among women, blacks, and individuals aged
Source: JAHA:Journal of the American Heart Association - September 23, 2016 Category: Cardiology Authors: Ramirez, L., Kim-Tenser, M. A., Sanossian, N., Cen, S., Wen, G., He, S., Mack, W. J., Towfighi, A. Tags: Epidemiology, Transient Ischemic Attack (TIA) Original Research Source Type: research

Factors Associated With Initial Prasugrel Versus Clopidogrel Selection for Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: Insights From the Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study Coronary Heart Disease
We examined patients presenting with acute myocardial infarction treated with percutaneous coronary intervention at 233 US hospitals in the TRANSLATE‐ACS observational study from April 2010 to October 2012. We developed a multivariable logistic regression model to identify factors associated with prasugrel selection. Prasugrel use rates and associated 1‐year risk‐adjusted major adverse cardiovascular events and Global Utilization of Streptokinase and t‐PA for Occluded Coronary Arteries (GUSTO) moderate/severe bleeding outcomes were also examined in relation to predicted mortality and bleeding using the validated Ac...
Source: JAHA:Journal of the American Heart Association - September 22, 2016 Category: Cardiology Authors: Vora, A. N., Peterson, E. D., McCoy, L. A., Effron, M. B., Anstrom, K. J., Faries, D. E., Zettler, M. E., Fonarow, G. C., Baker, B. A., Stone, G. W., Wang, T. Y. Tags: Acute Coronary Syndromes, Coronary Artery Disease Original Research Source Type: research

MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice Stroke
ConclusionsMKEY injection protects against stroke‐induced brain injury, probably by inhibiting MoMΦ‐mediated neuroinflammation.
Source: JAHA:Journal of the American Heart Association - September 14, 2016 Category: Cardiology Authors: Fan, Y., Xiong, X., Zhang, Y., Yan, D., Jian, Z., Xu, B., Zhao, H. Tags: Ischemic Stroke, Neuroprotectants Original Research Source Type: research

Impact of Blood Pressure Control on Thromboembolism and Maȷor Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J-RHYTHM Registry Arrhythmia and Electrophysiology
BackgroundTo clarify the influence of hypertension and blood pressure (BP) control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed.Methods and ResultsA consecutive series of outpatients with atrial fibrillation was enrolled from 158 institutions. Of 7937 patients, 7406 with nonvalvular atrial fibrillation (70.8% men, 69.8±10.0 years) were followed for 2 years or until an event occurred. Hypertension was defined as a systolic BP ≥140 mm Hg, a diastolic BP ≥90 mm Hg, a history of hypertension, and/or antihyperten...
Source: JAHA:Journal of the American Heart Association - September 11, 2016 Category: Cardiology Authors: Kodani, E., Atarashi, H., Inoue, H., Okumura, K., Yamashita, T., Otsuka, T., Tomita, H., Origasa, H. Tags: Atrial Fibrillation, High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research

Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J-RHYTHM Registry Arrhythmia and Electrophysiology
Conclusions BP control appears to be more important than a history of hypertension and baseline BP values at preventing thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation. Clinical Trial Registration URL: http://www.umin.ac.jp/ctr. Unique identifier: UMIN000001569.
Source: JAHA:Journal of the American Heart Association - September 11, 2016 Category: Cardiology Authors: Kodani, E., Atarashi, H., Inoue, H., Okumura, K., Yamashita, T., Otsuka, T., Tomita, H., Origasa, H., the J-RHYTHM Registry Investigators Tags: Atrial Fibrillation, High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Impact of Hemoglobin Levels and Anemia on Mortality in Acute Stroke: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis Stroke
Conclusions Strong evidence suggests that patients with anemia have increased mortality with stroke. Targeted interventions in this patient population may improve outcomes and require further evaluation.
Source: JAHA:Journal of the American Heart Association - August 16, 2016 Category: Cardiology Authors: Barlas, R. S., Honney, K., Loke, Y. K., McCall, S. J., Bettencourt-Silva, J. H., Clark, A. B., Bowles, K. M., Metcalf, A. K., Mamas, M. A., Potter, J. F., Myint, P. K. Tags: Epidemiology, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Source Type: research

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