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Early Clopidogrel Versus Prasugrel Use Among Contemporary STEMI and NSTEMI Patients in the US: Insights From the National Cardiovascular Data Registry Coronary Heart Disease
Conclusions With prasugrel as an antiplatelet treatment option, contemporary practice shows low uptake of prasugrel and delays in P2Y12 antagonist initiation among NSTEMI patients. We also note concerning evidence of inappropriate use of prasugrel, and inadequate targeting of this more potent therapy to maximize the benefit/risk ratio.
Source: JAHA:Journal of the American Heart Association - April 14, 2014 Category: Cardiology Authors: Sherwood, M. W., Wiviott, S. D., Peng, S. A., Roe, M. T., DeLemos, J., Peterson, E. D., Wang, T. Y. Tags: Coronary Heart Disease Source Type: research

Long-term Cardiovascular Outcomes in Patients With Chronic Kidney Disease Undergoing Coronary Artery Bypass Graft Surgery for Acute Coronary Syndromes Cardiovascular Surgery
Conclusions Severe, but not moderate, renal dysfunction was independently associated with an increased risk of long-term cardiovascular events and death in patients undergoing CABG for acute coronary syndromes.
Source: JAHA:Journal of the American Heart Association - March 4, 2014 Category: Cardiology Authors: Holzmann, M., Jernberg, T., Szummer, K., Sartipy, U. Tags: Cardiovascular Surgery Source Type: research

New-Onset Atrial Fibrillation is Associated With Cardiovascular Events Leading to Death in a First Time Myocardial Infarction Population of 89 703 Patients With Long-Term Follow-Up: A Nationwide Study Coronary Heart Disease
Conclusions New-onset AF after first-time MI is associated with increased mortality, which is largely explained by more cardiovascular deaths. Focus on the prognostic impact of post-infarct AF is warranted.
Source: JAHA:Journal of the American Heart Association - January 21, 2014 Category: Cardiology Authors: Bang, C. N., Gislason, G. H., Greve, A. M., Bang, C. A., Lilja, A., Torp-Pedersen, C., Andersen, P. K., Kober, L., Devereux, R. B., Wachtell, K. Tags: Coronary Heart Disease Source Type: research

Perceived Stress Is Associated With Incident Coronary Heart Disease and All-Cause Mortality in Low- but Not High-Income Participants in the Reasons for Geographic And Racial Differences in Stroke Study Coronary Heart Disease
Conclusions High stress was associated with greater risks of CHD and death for individuals with low but not high income.
Source: JAHA:Journal of the American Heart Association - December 19, 2013 Category: Cardiology Authors: Redmond, N., Richman, J., Gamboa, C. M., Albert, M. A., Sims, M., Durant, R. W., Glasser, S. P., Safford, M. M. Tags: Coronary Heart Disease Source Type: research

Circulating and Dietary Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Incidence of CVD in the Multi-Ethnic Study of Atherosclerosis Epidemiology
Conclusions Both dietary and circulating eicosapentaenoic acid and docosahexaenoic acid, but not alpha-linolenic acid or n-6 PUFA, were inversely associated with CVD incidence. These findings suggest that increased consumption of n-3 PUFA from seafood may prevent CVD development in a multiethnic population.
Source: JAHA:Journal of the American Heart Association - December 18, 2013 Category: Cardiology Authors: de Oliveira Otto, M. C., Wu, J. H. Y., Baylin, A., Vaidya, D., Rich, S. S., Tsai, M. Y., Jacobs, D. R., Mozaffarian, D. Tags: Epidemiology Source Type: research

Association of Ideal Cardiovascular Health Metrics and Retinal Microvascular Findings: The Atherosclerosis Risk in Communities Study Epidemiology
Conclusions Few adults had ideal cardiovascular health. Those with the best level of health were less likely to have retinopathy signs, wide retinal venules, and narrow retinal arterioles, which are associated with increased stroke and coronary heart disease risk.
Source: JAHA:Journal of the American Heart Association - November 19, 2013 Category: Cardiology Authors: Ogagarue, E. R., Lutsey, P. L., Klein, R., Klein, B. E., Folsom, A. R. Tags: Epidemiology Source Type: research

Hostility, Health Behaviors, and Risk of Recurrent Events in Patients With Stable Coronary Heart Disease: Findings From the Heart and Soul Study Epidemiology
Conclusions Hostility was a significant predictor of secondary events in this sample of outpatients with baseline stable CHD. Much of this association was moderated by poor health behaviors, specifically physical inactivity and smoking.
Source: JAHA:Journal of the American Heart Association - September 30, 2013 Category: Cardiology Authors: Wong, J. M., Na, B., Regan, M. C., Whooley, M. A. Tags: Epidemiology Source Type: research

Clopidogrel Use Is Associated With an Increased Prevalence of Cerebral Microbleeds in a Stroke-Free Population: The Rotterdam Study Stroke
Conclusions In stroke-free individuals, clopidogrel use was associated with a higher prevalence and higher number of CMBs. Whether this association is causal requires confirmation in prospective studies, especially given the small number of participants taking clopidogrel and the possibility of residual confounding in this study.
Source: JAHA:Journal of the American Heart Association - September 26, 2013 Category: Cardiology Authors: Darweesh, S. K. L., Leening, M. J. G., Akoudad, S., Loth, D. W., Hofman, A., Arfan Ikram, M., Vernooij, M. W., Stricker, B. H. Tags: Stroke Source Type: research

Simple Integer Risk Score to Determine Prognosis of Patients With Hypertension and Chronic Stable Coronary Artery Disease Coronary Heart Disease
Conclusion Readily available clinical variables can rapidly stratify patients with hypertension and chronic stable CAD into useful risk categories.
Source: JAHA:Journal of the American Heart Association - August 15, 2013 Category: Cardiology Authors: Bavry, A. A., Kumbhani, D. J., Gong, Y., Handberg, E. M., Cooper-DeHoff, R. M., Pepine, C. J. Tags: Coronary Heart Disease Source Type: research

Effectiveness of Percutaneous Coronary Intervention With Drug-Eluting Stents Compared With Bypass Surgery in Diabetics With Multivessel Coronary Disease: Comprehensive Systematic Review and Meta-analysis of Randomized Clinical Data Coronary Heart Disease
Conclusions These data demonstrate that CABG in diabetic patients with MVD at low to intermediate surgical risk (defined as EUROSCORE <5) is superior to MVD PCI with DES. CABG decreased overall death, nonfatal myocardial infarction, and repeat revascularization at the expense of an increase in stroke risk.
Source: JAHA:Journal of the American Heart Association - August 7, 2013 Category: Cardiology Authors: Hakeem, A., Garg, N., Bhatti, S., Rajpurohit, N., Ahmed, Z., Uretsky, B. F. Tags: Coronary Heart Disease Source Type: research

The Value of Carotid Artery Plaque and Intima-Media Thickness for Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis Epidemiology
Conclusion Ultrasound-derived plaque metrics independently predict cardiovascular events in our cohort and improve risk prediction for CHD events when added to Framingham risk factors.
Source: JAHA:Journal of the American Heart Association - April 8, 2013 Category: Cardiology Authors: Polak, J. F., Szklo, M., Kronmal, R. A., Burke, G. L., Shea, S., Zavodni, A. E. H., O'Leary, D. H. Tags: Epidemiology Source Type: research

Diminished Antioxidant Activity of High-Density Lipoprotein-Associated Proteins in Chronic Kidney Disease Coronary Heart Disease
Conclusions In patients with CKD, decreased serum arylesterase activity, a measure of diminished antioxidant properties of PON-1, predicts higher risk of incident long-term adverse cardiovascular events (heart attack, stroke, or death) in multivariable models adjusting for established clinical and biochemical risk factors.
Source: JAHA:Journal of the American Heart Association - April 4, 2013 Category: Cardiology Authors: Kennedy, D. J., Wilson Tang, W. H., Fan, Y., Wu, Y., Mann, S., Pepoy, M., Hazen, S. L. Tags: Coronary Heart Disease Source Type: research

Sex-Specific Differences in the Predictive Value of Cholesterol Homeostasis Markers and 10-Year Cardiovascular Disease Event Rate in Framingham Offspring Study Participants Coronary Heart Disease
Conclusions These data suggest significant sex differences in the 10-year prognostic value of cholesterol synthesis markers and HCHD, specifically coronary death and incidence of myocardial infarction. Clinical Trial Registration URL:http://ClinicalTrials.gov. Unique identifier: NCT00074464.
Source: JAHA:Journal of the American Heart Association - February 19, 2013 Category: Cardiology Authors: Matthan, N. R., Zhu, L., Pencina, M., D'Agostino, R. B., Schaefer, E. J., Lichtenstein, A. H. Tags: Coronary Heart Disease Source Type: research

Associations of Plasma Phospholipid and Dietary Alpha Linolenic Acid With Incident Atrial Fibrillation in Older Adults: The Cardiovascular Health Study Arrhythmia and Electrophysiology
Conclusions Results from this prospective cohort study of older adults indicate no association of plasma phospholipid or dietary ALA and incident AF.
Source: JAHA:Journal of the American Heart Association - January 31, 2013 Category: Cardiology Authors: Fretts, A. M., Mozaffarian, D., Siscovick, D. S., Heckbert, S. R., McKnight, B., King, I. B., Rimm, E. B., Psaty, B. M., Sacks, F. M., Song, X., Spiegelman, D., Lemaitre, R. N. Tags: Arrhythmia and Electrophysiology Source Type: research

Dynamic TIMI Risk Score for STEMI Coronary Heart Disease
Conclusions This score is a prospectively derived, validated means of estimating 1-year mortality of STEMI at hospital discharge and can serve as a clinically useful tool. By incorporating events during the index hospitalization, it can better define risk and help to guide treatment decisions.
Source: JAHA:Journal of the American Heart Association - January 29, 2013 Category: Cardiology Authors: Amin, S. T., Morrow, D. A., Braunwald, E., Sloan, S., Contant, C., Murphy, S., Antman, E. M. Tags: Coronary Heart Disease Source Type: research

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