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Importance of Considering Competing Risks in Time-to-Event Analyses: Application to Stroke Risk in a Retrospective Cohort Study of Elderly Patients With Atrial Fibrillation Original Articles
Conclusions: The incidence of death without stroke was 9-fold higher than that of stroke, leading to biased estimates of stroke risk with traditional time-to-event methods. Statistical methods that appropriately account for competing risks should be used to mitigate this bias.
Source: Circulation: Cardiovascular Quality and Outcomes - July 11, 2018 Category: Cardiology Authors: Abdel-Qadir, H., Fang, J., Lee, D. S., Tu, J. V., Amir, E., Austin, P. C., Anderson, G. M. Tags: Atrial Fibrillation, Epidemiology, Primary Prevention, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Abstract 175: Atrial Fibrillation in the USF Resident Clinics: Quality-Driven Medical Therapy Session Title: Poster Session AM
Patients with atrial fibrillation (afib) have a high rate of serious complications including stroke and decompensated heart failure. While patients with afib are five times more likely to suffer a stroke in their lifetime than the general population, this risk can be reduced by 64% with appropriate anticoagulation using warfarin or approved novel oral anticoagulants (NOACs). Reducing the morbidity and mortality from excess strokes is a common interest nationwide due to unsustainable healthcare costs, increasing human resource gaps in medicine, and payment reforms that hold physicians and healthcare organizations financiall...
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Sadic, E. Tags: Session Title: Poster Session AM Source Type: research

Abstract 204: Cardiovascular Mortality and Non-fatal Cardiovascular Events After Diagnosis of Acute Aortic Syndrome Session Title: Poster Session PM
Conclusions: AAS is associated with a higher overall mortality and an increased risk of any first time CV event, first time MI and HF that persists beyond the acute phase. These data highlight the risk of CV events among those with AAS and implicate the need for long-term cardiovascular management in these patients.
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Weiss, S., Sen, I., Huang, Y., Killian, J. M., Harmsen, W. S., Mandrekar, J., Chamberlain, A. M., Goodney, P. P., Roger, V. L., DeMartino, R. R. Tags: Session Title: Poster Session PM Source Type: research

Abstract 208: A Large, Retrospective Cohort Study Comparing Cardiovascular Outcomes With {beta}-blocker Combination Treatment in Patients With Hypertension Session Title: Poster Session PM
Conclusions: In adults receiving combination antihypertension therapy, NEB treatment was associated with a lower risk for CV-related hospitalization than either ATN or MET. Lower risk of hospitalization was supported by event rate data, as patients receiving NEB combined with other antihypertensives were hospitalized less frequently than patients receiving combination therapy with either ATN or MET.
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Punzi, H., Ali, S., Li, Q., Patel, M., Neutel, J. Tags: Session Title: Poster Session PM Source Type: research

Abstract 209: Education Level and Long-Term Outcomes After Acute Myocardial Infarction: The China PEACE Prospective AMI Study Session Title: Poster Session PM
Conclusions: In a national Chinese cohort of patients hospitalized with AMI, lower educational attainment was associated with a higher risk of adverse events in the year following discharge. This association highlights the need to explore mechanisms underlying this relationship, and to consider interventions for adults with lower levels of education.
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Huo, X., Khera, R., Zhang, L., Wang, Q., Herrin, J., Lu, Y., Nasir, K., Hu, S., Li, J., Li, X., Zheng, X., Masoudi, F. A., Spertus, J. A., Krumholz, H. M., Jiang, L. Tags: Session Title: Poster Session PM Source Type: research

Thirty-Year Mortality After Coronary Artery Bypass Graft Surgery: A Danish Nationwide Population-Based Cohort Study Original Articles
Conclusions— The isolated CABG cohort had a higher mortality rate than the general population comparison cohort, especially within 30 days of and 10 years after surgery.
Source: Circulation: Cardiovascular Quality and Outcomes - May 12, 2017 Category: Cardiology Authors: Adelborg, K., Horvath-Puho, E., Schmidt, M., Munch, T., Pedersen, L., Nielsen, P. H., Botker, H. E., Toft Sorensen, H. Tags: Cardiovascular Surgery, Mortality/Survival, Coronary Artery Disease Original Articles Source Type: research

Abstract 236: Coronary Artery Procedures in the Cardiac Catheterization Laboratory After Overnight Call: Are Patients at Higher Risk? Session Title: Poster Session II
Conclusion: There were greater procedural complications when performed post-call compared to no post-call; however, when adjusting for significant baseline variables, there was no significant difference seen between groups. Taking into consideration factors that contributed to procedural complications most likely will improve patient outcomes.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Boudoulas, K. D., Pederzolli, A., Nagaraja, H., Kahaly, O., Magorien, R., Mazzaferri, E. Tags: Session Title: Poster Session II Source Type: research

Abstract 239: A Field Synopsis of the Role of Race in Clinical Prediction Models for Cardiovascular Disease Session Title: Poster Session II
Conclusions: Race/ethnicity is rarely included in CVD-related CPMs, although racial and ethnic differences in outcome risk have been documented for many conditions, and several commonly used CPMs include race. Model development from cohorts including greater numbers of non-white patients may uncover additional or more consistent racial/ethnic effects.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Paulus, J. K., Wessler, B., Lundquist, C., Kent, D. M. Tags: Session Title: Poster Session II Source Type: research

Abstract 244: Revision of the Consent Form for Coronary Angiography Procedures Session Title: Poster Session II
Conclusion: In a representative assessment of coronary angiography and PCI outcomes, some major complications are higher that those reported in international literature. Significant access site bleeding was low, likely explained by the high prevalence of radial procedures. Future iterations of the patient information sheet and consent form may be improved by providing personalized risks.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Tavella, R., Halliday, L., Arstall, M., Worthley, M., Chew, D., Zeitz, C., Beltrame, J. F. Tags: Session Title: Poster Session II Source Type: research

Abstract 013: Using the Diabetes Collaborative Registry (DCR) to Estimate the Potential Real-world Impact of the Iris Trial on Improving Outcomes in Patients With Cerebrovascular Disease Session Title: Poster Session I
Conclusion: In a large US-based outpatient registry, we found that 12% of outpatients with prediabetes or diet-controlled T2D met the main eligibility criteria for IRIS, partly due to the narrow inclusion criteria of the trial but also likely reflective of a general paucity of screening for prediabetes and insulin resistance in this cohort. Pioglitazone was rarely used in these patients but could have a substantial impact on CV outcomes in these eligible patients. The population impact could be even greater if the CV benefit of pioglitazone can be demonstrated in patients with cerebrovascular disease and overt T2D or even ...
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Arnold, S. V., Inzucchi, S. E., Tang, F., McGuire, D. K., Mehta, S. N., Maddox, T. M., Goyal, A., Sperling, L. S., Einhorn, D., Wong, N. D., Kosiborod, M. Tags: Session Title: Poster Session I Source Type: research

Abstract 127: Differences in Care Patterns, Health Status, and Outcomes of Atrial Fibrillation in Patients With and Without Diabetes: Findings From the ORBIT-AF Registry Session Title: Poster Session I
Conclusions: Among patients with AF, diabetes was associated with worse AF symptoms and lower quality of life, as well an increased risk of death and hospitalizations, but not with the risk of thromboembolic or bleeding events.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Echouffo Tcheugui, J. B., Shrader, P., Thomas, L., Gersh, B. J., Kowey, P., Mahaffey, K. W., Singer, D. E., Hylek, E. M., Go, A. S., Peterson, E. D., Piccini, J. P., Fonarow, G. C. F. C. Tags: Session Title: Poster Session I Source Type: research

Abstract 137: Clinical Outcomes After Cardiac Stress Testing Among U.S. Patients Younger Than 65, 2006-2012 Session Title: Poster Session I
Conclusion: The percentage of commercially insured U.S. patients who had an AMI or revascularization event within 1 year of stress testing was small. In the lowest risk quintile, the a priori prevalence of coronary disease risk factors was low, and the rates of subsequent AMI and revascularization was extremely low, raising questions about the value of stress testing in this subgroup.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Kini, V., Dayoub, E., Marzec, L., Dickinson, M., Wynia, M., Masoudi, F., Ho, M., Groeneveld, P. Tags: Session Title: Poster Session I Source Type: research

Abstract 171: Improving Adherence to Antihypertensive Agents for Hypertensive Patient With Chronic Kidney Disease Session Title: Poster Session II
Conclusions: Good MA is associated with a greater controlled hypertension, better protection of heart and kidney and may decrease mortality than the poor MA.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Li, Y., Zeng, X., Zeng, X., Xie, J. Tags: Session Title: Poster Session II Source Type: research

Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis Original Article
Conclusions— Preeclampsia is associated with a 4-fold increase in future incident heart failure and a 2-fold increased risk in coronary heart disease, stroke, and death because of coronary heart or cardiovascular disease. Our study highlights the importance of lifelong monitoring of cardiovascular risk factors in women with a history of preeclampsia.
Source: Circulation: Cardiovascular Quality and Outcomes - February 21, 2017 Category: Cardiology Authors: Wu, P., Haththotuwa, R., Kwok, C. S., Babu, A., Kotronias, R. A., Rushton, C., Zaman, A., Fryer, A. A., Kadam, U., Chew-Graham, C. A., Mamas, M. A. Tags: Cardiovascular Disease, Pregnancy, Risk Factors, Women, Preeclampsia Original Article Source Type: research

Effects of Vascular and Nonvascular Adverse Events and of Extended-Release Niacin With Laropiprant on Health and Healthcare Costs Original Articles
Conclusions— In HPS2-THRIVE, the addition of extended-release niacin–laropiprant to statin-based therapy reduced quality of life–adjusted survival and increased hospital costs. Clinical Trial Registration— URL: http://clinicaltrials.gov. Unique identifier: NCT00461630.
Source: Circulation: Cardiovascular Quality and Outcomes - July 18, 2016 Category: Cardiology Authors: Kent, S., Haynes, R., Hopewell, J. C., Parish, S., Gray, A., Landray, M. J., Collins, R., Armitage, J., Mihaylova, B., on behalf of the HPS2-THRIVE Collaborative Group Tags: Cardiovascular Disease, Treatment, Cost-Effectiveness, Quality and Outcomes, Vascular Disease Original Articles Source Type: research

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