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Abstract P421: The Effects of Dual Angiotensin Receptor and Neprilysin Inhibitor on Organoprotection in Experimental Model of Chronic Heart Failure Session Title: Renin-Angiotensin System
The cardiac effects of dual angiotensin receptor and neprilysin inhibitor (LCZ696) as a novel therapeutic approach for inhibition of renin-angiotensin system was assessed in volume overload-induced chronic heart failure (CHF) in hypertensive Ren2 transgenic rats (TGR) with aorto-caval fistula (ACF) and compared with valsartan (VAL). CHF model was induced by ACF in male TGR at 8 weeks of age. After 5 weeks of ACF induction, LCZ696 was administered in standard dosing at 68 mg/kg/day and VAL at 31 mg/kg/day for next 15 weeks to assess the effect on mortality. In second series, 12 weeks after ACF, the animals were anaesthetize...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Libor Kopkan, Lenka Hoskova, Voȷtech Melenovsky, Zuzana Huskova, Ludek Cervenka Tags: Poster Abstract Presentations Source Type: research

Roles of Caveolin-1 in Angiotensin II-Induced Hypertrophy and Inward Remodeling of Cerebral Pial Arterioles Vessel Remodeling
In conclusion, Cav-1 is essential in Ang II–mediated inward remodeling and hypertrophy in pial arterioles. Cav-1–induced MMP9 is exclusively involved in inward remodeling, not hypertrophy. Further studies are needed to determine the role of Akt in Ang II–mediated hypertrophy.
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: Umesalma, S., Houwen, F. K., Baumbach, G. L., Chan, S.-L. Tags: Hypertension, Vascular Disease Vessel Remodeling Source Type: research

Abstract P159: Effect of Pharmacological Kinin Receptor Activation on Brain Damage and Mortality in Experimental Cerebral Ischemia in Non-diabetic and Diabetic Mice Session Title: Cerebrovascular Disease and Stroke
Brain ischemia is a major complication of arterial diseases and has a poorer prognosis in diabetic patients. As activation of the kallikrein-kinin system has been shown to enhance cardiac and renal tolerance to ischemia we tested effect of kinin receptor activation by pharmacological agonists, selective B1R or B2R, in a mouse model of transient middle cerebral artery occlusion [C57bl6 male, 10 week-old, anaesthesia, occlusion 60 min (MCAO)]. Treatment with the B1R agonist NG29 (B1Rago) or the B2R agonist NG291 (B2Rago) was started at reperfusion using osmotic micropumps. Neurological deficit (ND) was evaluated at 1 and 2 d...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Desposito, D., Taveau, C., Zadigue, G., Adam, C., Bouby, N., Alhenc-Gelas, F., Roussel, R. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Epidermal Growth Factor Receptor Is Critical For Angiotensin II-Mediated Hypertrophy in Cerebral Arterioles Renin-Angiotensin System
We examined the molecular mechanism of Ang II–mediated cerebrovascular remodeling that involves the epidermal growth factor receptor (EGFR) pathway. Mutant EGFR mice (waved-2), their heterozygous control (wild-type [WT]), and C57BL/6J mice were infused with Ang II (1000 ng kg–1 min–1) or saline via osmotic minipumps for 28 days (n=8 per group). Eight of the Ang II–infused C57BL/6J mice were cotreated with AG1478 (12 mg/kg per day, IP), a specific EGFR tyrosine kinase inhibitor. Systolic arterial pressure was measured by a tail-cuff method. Pressure and diameter of cerebral arterioles were measured t...
Source: Hypertension - March 11, 2015 Category: Cardiology Authors: Chan, S.-L., Umesalma, S., Baumbach, G. L. Tags: Cerebrovascular disease/stroke, Hypertrophy, Other Vascular biology Renin-Angiotensin System Source Type: research

Abstract 567: Combined Treatment With Irbesartan and Vitamin D Retards Renal Injury in Salt-loaded Uni-nephrectomized Stroke-prone Spontaneously Hypertensive Rats Poster Session II
Vitamin D diminishes renin expression. In addition, we previously reported that vitamin D increased renal expression of klotho in rats with normal kidney function. In the present study, effects of vitamin D on renal injury was assessed in four groups of rats (n=6-8 for each group); uni-nephrectomized stroke-prone spontaneously hypertensive rats fed high salt (6%) diet as a control (C), those treated with irbesartan (100 mg/kg/day) (I), rats treated with calcitriol (30 ng/kg/day) (V), and rats treated with both irbesartan and calcitriol (I+V). Six weeks later, rats were killed with over-anesthesia, and harvested right kidne...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Takenaka, T., Inoue, T., Ohno, Y., Miyazaki, T., Nishiyama, A., Ishii, N., Suzuki, H. Tags: Poster Session II Source Type: research