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Source: The Journal of Heart and Lung Transplantation

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Total 231 results found since Jan 2013.

Anticoagulation Reversal With 4-Factor Prothrombin Complex Concentrate in Left Ventricular Assist Device Patients With Acute Hemorrhagic Stroke
Anticoagulation reversal in patients with left ventricular assist devices (LVAD) after acute hemorrhagic stroke must occur rapidly to prevent hemorrhage expansion and limit neurologic sequelae, keeping in mind the risk of thrombotic complications. The purpose of this study was to report a case series of our initial experience using a recently FDA approved (April 2013) 4-factor prothrombin complex concentrate (4F-PCC) for INR normalization after acute hemorrhagic stroke in LVAD patients, and compare the results with traditional INR reversal agents.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: P. Chen, J. Falvey, L. Lowenstein, A. Miranpuri, W. Hallinan, T. Massey Source Type: research

Impact of a Modified Anti-Thrombotic Protocol on the Risk of Stroke and Thromboembolism in Children Supported With the Berlin Heart Excor Pediatric Ventricular Assist Device
Stroke is the most recognized complication associated with the Berlin Heart EXCOR® Pediatric ventricular assist device (VAD). We sought to determine whether a modified anti-thrombotic protocol, involving more intense platelet inhibition and less reliance on Thromboelastrography/ Platelet Mapping™ (TEG/PM), is associated with a lower incidence of stroke.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: C.A. Lancaster, C.S. Almond, S.A. Hollander, M.L. Stein, A. Lin, L. Doan, J. Murray, D.N. Rosenthal Source Type: research

Gender differences in the risk of stroke during support with continuous flow left ventricular assist device
There is increasing recognition that the risk of stroke after left ventricular assist device (LVAD) varies based on gender, with a higher risk in female patients. We reviewed our own data to determine gender differences in the risk of stroke.
Source: The Journal of Heart and Lung Transplantation - September 3, 2015 Category: Transplant Surgery Authors: Alanna A. Morris, Ann Pekarek, Kris Wittersheim, Robert T. Cole, Divya Gupta, Duc Nguyen, S. Raja Laskar, Javed Butler, Andrew Smith, J. David Vega Source Type: research

Gender differences in the risk of stroke during support with continuous-flow left ventricular assist device
There is increasing recognition that the risk of stroke after left ventricular assist device (LVAD) implantation varies based on gender, with a higher risk in female patients. We reviewed our own data to determine gender differences in the risk of stroke.
Source: The Journal of Heart and Lung Transplantation - September 3, 2015 Category: Transplant Surgery Authors: Alanna A. Morris, Ann Pekarek, Kris Wittersheim, Robert T. Cole, Divya Gupta, Duc Nguyen, S. Raja Laskar, Javed Butler, Andrew Smith, J. David Vega Tags: Original Clinical Science Source Type: research

Does Type of Mechanical Circulatory Support Influence Stroke Risk in the Perioperative Post Transplant Period?
This study was undertaken to assess if the type of circulatory support device used has an impact on stroke risk in this population.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: N. Nair, S. Yang, E. Gongora Source Type: research

(1205) Does Stroke in the Perioperative Post Cardiac Transplant Period Impact Survival?
This study addresses the effect of stroke on overall survival in this population.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: N. Nair, S. Yang, E. Gongora Source Type: research

Impact of a Modified Anti-Thrombotic Guideline On Stroke In Children Supported with A Pediatric Ventricular Assist Device
Stroke is the most feared complication associated with the Berlin Heart EXCOR ® Pediatric ventricular assist device (VAD), the most commonly used VAD in children, and affects one in three children. We sought to determine whether a modified anti-thrombotic guideline, involving more intense platelet inhibition and less reliance on platelet function testing, is associated with a lower incidence of stroke.
Source: The Journal of Heart and Lung Transplantation - May 20, 2017 Category: Transplant Surgery Authors: David N. Rosenthal, Chacy A. Lancaster, Doff B. McElhinney, Sharon Chen, MaryLyn Stein, Aileen Lin, Lan Doan, Jenna M. Murray, Mary Alice Gowan, Katsuhide Maeda, Olaf Reinhartz, Christopher S. Almond Source Type: research

Early stroke post –heart transplant is associated with decreased survival in children
In this study we aimed to characterize early MNEs (stroke, isolated seizures not from stroke and posterior reversible leukoencephalopathy [PRES] within 1 year after primary pediatric HTx) and evaluate their impact on 1-year post-HTx survival. We hypothesized that early an MNE after HTx is associated with decreased 1-year patient survival.
Source: The Journal of Heart and Lung Transplantation - January 8, 2018 Category: Transplant Surgery Authors: Cheryl Cammock, Swati Choudhry, Chesney M. Castleberry, Noor Al-Hammadi, Pirooz Eghtesady, Charles E. Canter, Kathleen E. Simpson Tags: Original Clinical Science Source Type: research

Stroke Patterns and Implications for Ventricular Functional Remodeling in Left Ventricular Assist Systems
Ischemic stroke-related complications (particularly in the right hemisphere) are frequently encountered with Left Ventricular Assist Systems (LVAS). The neuro-cardiac axis may influence ventricular remodeling. However it remains unknown if stroke patterns are related to ventricular remodeling after facilitated hemodynamic support with LVAS. We hypothesized that strokes occurring in the right hemisphere, within the insula region, may enhance left ventricular remodeling through unopposed activation of the left insular region.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: D.F. Snipelisky, P. Ivak, G. Stewart, M. Givertz, M. Pfeffer, J. Groarke, S. Singh, I. Netuka, M. Mehra Source Type: research

Clinical Profile of Patients with Late Stroke after Left Ventricular Assist Device Implantation
Despite advances in left ventricular assist device (LVAD) therapy, stroke remains a relatively frequent complication and is associated with significant morbidity and mortality. In the early postoperative period, stroke may be related to patient demographics, operative factors and comorbid conditions. Less is known about strokes that occur greater than six months after LVAD implantation. The aim of this study was to describe the clinical profile of patients with late strokes.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: J. Nnanabu, D. Rodgers, N. Sarswat, J. Raikhelkar, G. Kim, S. Kalantari, T. Ota, T. Song, C. Juricek, V. Jeevanandam, G. Sayer, N. Uriel Source Type: research

Increased Pump Speed is Associated with Reduced Rates of Stroke on HeartMate II LVAD Support
Higher pump speeds have recently been associated with reduced rates of pump thrombosis in the HeartMate II LVAD population. Whether pump speed is associated with stroke has not been well established. In this analysis we use a single center cohort to determine the association with discharge speed and all-cause stroke.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: J.N. Schultz, R. Cogswell, M. Prtizker, E. Missov, K. Liao, J. Misialek, R. John Source Type: research

Predictive Value of Mean Arterial Pressure Versus Systolic Blood Pressure and Visit-To-Visit Blood Pressure Variability for Stroke and Pump Thrombosis in HeartMate II Patients
Elevated blood pressure (BP) in pts on left ventricular assist device (LVAD) support is a risk factor for adverse events (AEs) such as stroke and pump thrombosis (PT). Current guidelines recommend a mean arterial pressure (MAP) ≤ 80mmHg. Above-median systolic BP (SBP) at discharge after HeartMate II (HMII) implant has been associated with an increased risk of stroke. We sought to 1) compare the predictive value of outpt MAP and SBP on AEs, 2) examine the association of visit-to-visit variability (VVV) of BP with AEs in H MII pts.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: A. Pinsino, F. Castagna, J.Z. Willey, A.M. Zuver, M.A. Flannery, B. Cagliostro, J.R. Cockroft, A.R. Garan, V.K. Topkara, H. Takayama, K. Takeda, Y. Naka, R.T. Demmer, P.C. Colombo, M. Yuzefpolskaya Source Type: research

Blood Pressure Control as a Risk Factor for Stroke in LVAD Patients- Single Center Experience
The ENDURANCE trial suggested an increased stroke (CVA) risk in Heartware HVAD compared to Heartmate 2 (HM2); a risk that could be mitigated with improved blood pressure control as demonstrated in the ENDURANCE 2 supplemental study. We hypothesized that better blood pressure control reduced the stroke risk in all LVAD supported patients.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: N.S. Clarke, R. Vela, J. Pruszynski, M. Drazner, L.C. Huffman, M. Peltz Source Type: research

Early stroke post –heart transplant is associated with decreased survival in children
In this study we aimed to characterize early MNEs (stroke, isolated seizures not from stroke and posterior reversible leukoencephalopathy [PRES] within 1 year after primary pediatric HTx) and evaluate their impact on 1-year post-HTx survival. We hypothesized that early an MNE after HTx is associated with decreased 1-year patient survival.
Source: The Journal of Heart and Lung Transplantation - January 8, 2018 Category: Transplant Surgery Authors: Cheryl Cammock, Swati Choudhry, Chesney M. Castleberry, Noor Al-Hammadi, Pirooz Eghtesady, Charles E. Canter, Kathleen E. Simpson Tags: Original Clinical Science Source Type: research

The Implication of HeartWare HVAD Inflow Cannula Angle on Stroke and Thrombus Rate
Stroke and ventricular assist device (VAD) pump thrombus are serious complications that have previously been thought to be related to surgical placement - namely VAD inflow cannula angle. Our aim with this study was to better elucidate the impact of post-operative HeartWare HVAD (left VAD) cannula inflow angle on stroke and thrombus rate within a single centre in Sydney, Australia.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S. Emmanuel, D. Aktuerk, A. Chowdhury, C. Hurwitz, L. Beiglari, P. Jansz, C. Hayward Tags: 1080 Source Type: research