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Source: The Journal of Heart and Lung Transplantation
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Total 231 results found since Jan 2013.
Blood Pressure Management Ameliorates the Severity of Neurological Events
The ENDURANCE Supplemental trial was designed to assess the effectiveness of an enhanced blood pressure (BP) management protocol in reducing the occurrence of neurological events in patients ineligible for cardiac transplantation receiving the Medtronic HeartWareTM HVADTM System. The trial demonstrated that enhanced BP management significantly reduced the mean arterial pressure (MAP) and the incidence of hemorrhagic strokes compared to the original ENDURANCE trial. This subsequent analysis sought to understand the effects of BP management on stroke severity and recovery.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: J.J. Teuteberg, J.G. Rogers, C.A. Milano, M.S. Kiernan, G.S. Couper, S.W. Boyce, C. Mahr, N.A. Mokadam, T.A. Vassiliades, F.D. Pagani Source Type: research
First-in-Man Use of the MVAD Axial-Flow Pump: Long Term Outcome
The use of durable continuous-flow mechanical assist devices provides selected heart failure patients with both symptomatic and functional benefits; however, they are not without potential complications. Infection, thrombosis, stroke and GI bleeding are amongst the most commonly reported problems of left ventricular assist device (LVAD) therapy.1 –3 In addition, LVAD peripherals can be bulky and heavy for the patient to carry, causing joint stress, discomfort and reduced quality of life. Device miniaturization is one design trend that has enabled device implantation in patients with a broader range of body sizes, and whe...
Source: The Journal of Heart and Lung Transplantation - April 24, 2018 Category: Transplant Surgery Authors: Marian Urban, Anfrew Woods, Nicola Robinson-Smith, Guy MacGowan, Chandrika Roysam, Stephan Schueler Source Type: research
Strategy for surgical correction and mitigation of outflow graft twist with a centrifugal-flow left ventricular assist system
A fully magnetically levitated centrifugal-flow left ventricular assist system (LVAS) has been introduced, with demonstration of improved hemocompatibility and reduced rates of pump malfunction, and stroke.1 –4 This LVAS, the HeartMate 3 (Abbott, Abbott Park, IL) pump, has been observed to have isolated cases of an outflow graft twist occurring in follow-up periods, later in the course of support.1,5 The mechanism for this development is incompletely understood. It may, however, be related to the prox imal outflow graft metallic swivel joint that allows relatively free rotation of this graft once implanted (Figure 1), wh...
Source: The Journal of Heart and Lung Transplantation - March 22, 2018 Category: Transplant Surgery Authors: Evgenij V. Potapov, Ivan Netuka, Friedrich Kaufmann, Volkmar Falk, Mandeep R. Mehra Tags: Research Correspondence Source Type: research
First-in-man use of the MVAD axial-flow pump: Long-term outcome
The use of durable continuous-flow mechanical assist devices provides selected heart failure patients with both symptomatic and functional benefits; however, they are not without potential complications. Infection, thrombosis, stroke, and gastrointesinal bleeding are among the most commonly reported problems of left ventricular assist device (LVAD) therapy.1 –3 In addition, LVAD peripherals can be bulky and heavy for the patient to carry, causing joint stress, discomfort, and reduced quality of life.
Source: The Journal of Heart and Lung Transplantation - April 24, 2018 Category: Transplant Surgery Authors: Marian Urban, Anfrew Woods, Nicola Robinson-Smith, Guy MacGowan, Chandrika Roysam, Stephan Schueler Tags: Case Anecdotes, Comments and Opinions Source Type: research
A Tale of the Twist in the Outflow Graft: An Analysis from the MOMENTUM 3 Trial
Heralded as a significant step forward in the evolution of left ventricular assist systems (LVAS), the HeartMate 3 device (Abbott, Abbott Park, Il, USA) has demonstrated improved outcomes by averting de-novo intra-pump thrombosis leading to pump related malfunction, and in reducing the incidence of stroke events when compared with the axial flow HeartMate II LVAS.1,2,3,4 Moreover, the HeartMate 3 LVAS experience has reduced the vexing incidence of hemocompatibility related adverse outcomes.5,6,7 On the heels of these advances, intriguing reports began to surface of a twist within the outflow graft that caused disruption in...
Source: The Journal of Heart and Lung Transplantation - August 24, 2018 Category: Transplant Surgery Authors: Mandeep R. Mehra, Christopher Salerno, Yoshifumi Naka, Nir Uriel, Joseph C. Cleveland, Douglas Horstmanshof, Daniel J. Goldstein, for the MOMENTUM 3 Investigators Tags: Editorial Source Type: research
Prognostic implications of serial outpatient blood pressure measurements in patients with a left ventricular assist device
Elevated blood pressure (BP) has been linked to adverse events during left ventricular assist device support. We aimed to investigate the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients.
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Alberto Pinsino, Francesco Castagna, Amelia M Zuver, Eugene A Royzman, Mojdeh Nasiri, Eric J St öhr, Barbara Cagliostro, Barry McDonnell, John R Cockcroft, A Reshad Garan, Veli K Topkara, P Christian Schulze, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Tags: Original Clinical Science Source Type: research
Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device
In this study we investigated the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients.
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Alberto Pinsino, Francesco Castagna, Amelia M. Zuver, Eugene A. Royzman, Mojdeh Nasiri, Eric J. St öhr, Barbara Cagliostro, Barry McDonnell, John R. Cockcroft, A. Reshad Garan, Veli K. Topkara, P. Christian Schulze, Koji Takeda, Hiroo Takayama, Yoshifumi Tags: ORIGINAL CLINICAL SCIENCE Source Type: research
Concentrated Factor Administration and Subsequent Stroke Rates on HeartMate II LVAD Support
Limited data exists regarding concentrated factor administration during continuous flow left ventricular assist device (CF-LVAD) implantation and subsequent neurologic events. While the hemocompatability profile of CF pumps are presently changing, this is the largest concentrated factor experience reported in a CF-LVAD population to date.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: J. Schultz, A. Shaffer, J. Misialek, H. Shah, R. John, C. Martin, T. Thenappan, T. Alexy, F. Kamdar, R. Cogswell Tags: 399 Source Type: research
Use of Pulmonary Arterial Catheters for Management of Acute Decompensated Heart Failure and Peri-Operative Monitoring in Children
Pulmonary arterial catheters (PAC) provide real-time hemodynamic data that has been used to tailor ICU therapies, aid in surgical decision making in adults with ADHF and in predicting right-heart failure (RHF) in adults undergoing LVAD evaluation. Approximately 1/3 of patients develop RVF after LVAD insertion. Patients who required rescue RVAD have increased mortality when compared to planned BiVAD implantation. Right ventricular stroke work index (RVSWI) has been demonstrated to predict RHF in adults.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P. Esteso, E.D. Blume, C. VanderPluym, F. Fynn-Thompson, K.P. Daly Tags: 1179 Source Type: research
Cardiac CT Provides Complementary Parameters of Right Ventricle Function in LVAD Patients
Patients receiving LVADs are at risk for post-operative right ventricular (RV) failure. Cardiac CT angiography (CTA) provides 3D isotropic spatial resolution and blood pool-myocardial delineation and can be used to assess ventricular volumes. We sought to evaluate whether right heart catheterization (RHC) and echocardiographic (echo) parameters of RV structure and function correlate with CT-derived parameters - specifically, RV ejection fraction RVEF, RV stroke volume index RVSVI, RV to LV end diastolic ratio RV-LVEDR, and RV end diastolic volume index RVEDVI.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: A. Scott, P.J. Kim, H. Tran, M. Brambatti, Y. Ignatyeva, S. Rosenberg, S. Kligerman, A. Hsiao, V. Pretorius, E. Adler, F. Contijoch Tags: 1160 Source Type: research
Novel Oral Anticoagulants in Patients with Continuous Flow Left Ventricular Assist Devices
The gold standard for anticoagulation in patients with continuous flow left ventricular assist device (CF-LVADs) is warfarin. However, many patients fail warfarin therapy due to thromboembolic and bleeding events. Warfarin requires regular monitoring and dosage adjustments, and is associated with significant patient time outside recommended therapeutic INR range. Novel oral anticoagulation (NOAC) has been shown to be non-inferior compared to warfarin in stroke prevention with less intracranial hemorrhage in patients with atrial fibrillation.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: V. Parikh, U. Parikh, A.M. Ramirez, H. Lamba, J. George, S. Fedson, F. Cheema, A. Civitello, A. Nair, A. Shafii, G. Loor, T. Rosengart, O. Frazier, J. Morgan, R. Delgado Tags: 1072 Source Type: research
Comorbidities and Biomarkers Vary between United States and Japanese LVAD Patients
Left ventricular assist device (LVAD) outcomes differ between Japan and US. While GI bleeding is common in US and rare in Japan, stroke and driveline infections are more common in Japan than US. The aim of this study was to explore whether inflammatory and angiogenesis biomarkers can explain these differences.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: T. Imamura, A. Nguyen, D. Nitta, T. Fujino, L. Holzhauser, D. Rodgers, S. Kalantari, B. Smith, J. Raikhelkar, N. Narang, B. Chung, I. Ebong, C. Juricek, P. Combs, D. Onsager, T. Song, T. Ota, V. Jeevanandam, G. Kim, G. Sayer, M. Ono, N. Uriel Tags: 1065 Source Type: research
Intracranial Hemorrage in Patients with Continous Flow LVAD
In this study the incidence of ICH, outcome and associated risk factors were evaluated.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: E. Demir, S. Nalbantgil, P. Öztürk, E. Simsek, C. Engin, T. Yağdı, M. Özbaran Tags: 1064 Source Type: research
Positive Correlation between P Wave Analysis and Severity of Heart Failure with Preserved and Reduced Ejection Fraction
Two separate studies by Morris et al. in 1964 and then He at al in 2017 were able to show a direct relationship between P wave analysis and valvular heart disease and ischemic stroke, respectively. We hope to continue this progress by establishing a relationship between P wave morphology, duration, PR interval, and P wave terminal force with the severity of Heart Failure with Preserved Ejection Fraction in our patient population.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: H. Patel, B. Allen, S. Almhameed, C. Musser Tags: 956 Source Type: research
