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Stroke and stroke prevention in sickle cell anemia in developed and selected developing countries
This comprehensive review provides an insight into the pathophysiology, epidemiology, evaluation, and treatment of sickle cell anemia (SCA)-related stroke in developed and developing countries. Vascular injury, hypercoagulability and vaso-occlusion play a role in the pathophysiology of stroke in SCA. Transcranial Doppler ultrasound (TCD) has lowered the incidence of ischemic stroke from 11% to 1% as TCD identifies children who are at risk for stroke, providing opportunities for interventions to reduce this risk.
Source: Journal of the Neurological Sciences - May 26, 2021 Category: Neurology Authors: Pallab Bhattacharya, Deepaneeta Sarmah, Kunjan R. Dave, Avirag Goswami, Mitsuyoshi Watanabe, Xin Wang, Kiran Kalia, Nikolaus Plesnila, Dileep R. Yavagal, Ofelia Alvarez Tags: Review Article Source Type: research

Acute ischemic stroke diagnosis using brain tissue pulsations
This study is the first to explore the clinical potential of measuring BTPs using ultrasound in acute ischemic stroke patients.BTPs were measured in 24 healthy volunteers (aged 52 –82 years) and 14 acute ischemic stroke patients (aged 51–86 years) using a novel Transcranial Tissue Doppler (TCTD) method. Measurements were quick to perform and were well tolerated by all subjects.
Source: Journal of the Neurological Sciences - October 2, 2020 Category: Neurology Authors: Jonathan Ince, Caroline Banahan, Sara Venturini, Meshal Alharbi, Poppy Turner, Mitsuhiro Oura, Kirk W. Beach, Thompson G. Robinson, Amit K. Mistri, Andrea Lecchini-Visintini, Jatinder S. Minhas, Emma M.L. Chung Source Type: research

Can transcranial Doppler ultrasound be used for screening cerebral small vessel diseases in the community?
Elderly persons harbouring severe white matter hyperintensity (WMH), a radiological manifestation of cerebral small vessel disease (SVD), have an increased risk of dementia, stroke and poor functional outcomes. A simple screening tool will enhance their recruitment into preventive trials for SVD. We explored the clinical utility of the pulsatility index (PI) of the middle cerebral artery (MCA), obtained from transcranial Doppler ultrasound (TCD), in identifying severe WMH among community elderly persons with vascular risk factors.
Source: Journal of the Neurological Sciences - August 28, 2019 Category: Neurology Authors: Candy Kang, Adrian Wong, Jianhui Fu, Xu Qun, Wenyan Liu, Zhaolu Wang, Shi Lin, Pauline Kwan, Eugene Lo, Lisa W.C. Au, Ho Ko, Alexander Y.L. Lau, Thomas W.H. Leung, Jill Abrigo, Winnie C.W. Chu, Vincent C.T. Mok, Bonnie Y.K. Lam Source Type: research

Can botulinum toxin type A injection technique influence the clinical outcome of patients with post-stroke upper limb spasticity? A randomized controlled trial comparing manual needle placement and ultrasound-guided injection techniques
Botulinum toxin type A is a first-line treatment for post-stroke focal spasticity, and the accuracy in delivering the toxin to the target muscles may influence the treatment outcome. Our aim was to compare the reduction of spasticity and the related finger position at rest improvement in post-stroke patients treated with botulinum toxin type A in upper limb muscles using ultrasound guidance and manual needle placement.
Source: Journal of the Neurological Sciences - September 18, 2014 Category: Neurology Authors: Andrea Santamato, Maria Francesca Micello, Francesco Panza, Francesca Fortunato, Alessio Baricich, Carlo Cisari, Alberto Pilotto, Giancarlo Logroscino, Pietro Fiore, Maurizio Ranieri Source Type: research