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Prevalence and predictors of statin utilization among patient populations at high vascular risk in Ghana
Inadequate implementation of evidence-based preventive measures for individuals at high risk of cardiovascular disease (CVD) will only worsen the current epidemic of CVDs in sub-Saharan Africa. We assessed rates and predictors of statin utilization among two high CVD risk patient populations, people with type 2 diabetes mellitus (T2DM) and those with stroke, encountered across five hospitals in Ghana.
Source: Journal of the Neurological Sciences - April 14, 2020 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele Source Type: research

Profile and determinants of vascular cognitive impairment in African stroke survivors: The CogFAST Nigeria Study
Sub-Saharan Africa faces a potential epidemic of non-communicable diseases including stroke and dementia but little is known about the burden of stroke-related cognitive dysfunction. We assessed the baseline profile and factors associated with vascular cognitive impairment (VCI) in stroke survivors participating in the Cognitive Function After STroke (CogFAST) Nigeria Study.
Source: Journal of the Neurological Sciences - September 1, 2014 Category: Neurology Authors: Rufus O. Akinyemi, Louise Allan, Mayowa O. Owolabi, Joshua O. Akinyemi, Godwin Ogbole, Akinlolu Ajani, Michael Firbank, Adesola Ogunniyi, Raj N. Kalaria Source Type: research

NR4A1 enhances neural survival following oxygen and glucose deprivation: An in vitro study
Abstract: A worldwide epidemic of stroke is exacting a huge level of patient suffering and social cost. The ischemia damage to neural cells and the associated permanent neural function loss are central to the pathophysiology of stroke.In the current study, we were endeavored to identify NR4A1, an orphan nuclear receptor as a novel protector for neural cells in an in vitro neural ischemia model. Our results showed that oxygen and glucose deprivation (OGD) dramatically induced primary culture neural cell apoptosis and NR4A1 expression at both protein and mRNA level. Furthermore, hyperexpression or knock-down of NR4A1 signifi...
Source: Journal of the Neurological Sciences - May 9, 2013 Category: Neurology Authors: Guodong Xiao, Tao Sun, Cheng Songming, Yongjun Cao Tags: Original Articles Source Type: research