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VZV reactivation: A comorbid connection?
Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus. Primary infection usually results in varicella (chickenpox), after which the virus becomes latent in ganglionic neurons along the entire neuraxis. As the VZV-specific cell-mediated immunity to VZV declines with age and immunosuppression, VZV can reactivate, resulting in zoster (shingles). Furthermore, zoster is often complicated by multiple neurological and ocular disorders. Among the most serious is VZV vasculopathy where the productive virus infection of cerebral arteries leads to stroke. The diverse manifestations, laboratory features, pathogenesis and trea...
Source: Journal of the Neurological Sciences - February 18, 2014 Category: Neurology Authors: Shilpa Buch Tags: Editorials Source Type: research