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Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch
Approved food and drug administration (FDA) medications to treat Psychostimulant Use Disorder (PUD) are needed. Both acute and chronic neurological deficits related to the neurophysiological effects of these powerfully addictive drugs can cause stroke and alterations in mood and cognition.
Source: Journal of the Neurological Sciences - November 27, 2020 Category: Neurology Authors: Kenneth Blum, Jean Lud Cadet, Mark S. Gold Tags: Review Article Source Type: research

Isolated persistent acute global amnesia after acute abuse of 3,4-methylenedioxy-methamphetamine (MDMA)
Acute global amnesia can occur, due to bilateral hippocampus dysfunction. Causes include the idiopathic syndrome of transient global amnesia, bilateral posterior circulation stroke,. toxic anoxia due to carbon monoxyde poisoning and substance abuse probably combining hypoxia and direct hippocampal neurotoxicity.
Source: Journal of the Neurological Sciences - January 4, 2018 Category: Neurology Authors: Fabien Hauw, Elodie Meppiel, Olivier Steichen, Pierre-Louis Conan, Jean Capron, Thomas de Broucker Tags: Letter to the Editor Source Type: research

Impaired arterial smooth muscle cell vasodilatory function in methamphetamine users
This study was designed to evaluate arterial function and structure in methamphetamine users ultrasonographically.Methods: In a cross-sectional study, 20 methamphetamine users and 21 controls, aged between 20 and 40years, were enrolled. Common carotid artery intima-media thickness (CCA-IMT) marker of early atherogenesis, flow-mediated dilatation (FMD) determinants of endothelium –dependent vasodilation, and nitroglycerine-mediated dilatation (NMD) independent marker of vasodilation were measured in two groups.
Source: Journal of the Neurological Sciences - September 16, 2016 Category: Neurology Authors: Ghaemeh Nabaei, Shahram Oveis Gharan, Askar Ghorbani, Farzad Fatehi Source Type: research