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Source: Journal of the Neurological Sciences
Drug: Dexamethasone
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Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats
Abstract: Isoflavone calycosin is a typical phytoestrogen extracted from Chinese medical herb Radix Astragali. It has been reported that estrogens could provide neuroprotective effects, and dietary intake of phytoestrogens could reduce stroke injury in cerebral ischemia/reperfusion (I/R) animal models. In the present study, we investigate the molecular mechanisms underlying the neuroprotective effects of calycosin on middle cerebral artery occlusion (MCAO) rats. Focal cerebral ischemia was induced in male rats by MCAO, neurological deficits and brain edema was evaluated after 24h of reperfusion. The results shown calycosin...
Source: Journal of the Neurological Sciences - February 18, 2014 Category: Neurology Authors: Yong Wang, Xianhong Dong, Zhengzhao Li, Wenbo Wang, Jing Tian, Jian Chen Tags: Original Articles Source Type: research
