• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Acute leukoencephalopathy due to pyrimethamine. An insight into methotrexate neurotoxicity?
Abstract: A unique case of pyrimethamine-related stroke-like leukoencephalopathy is described. The imputability of the drug is discussed as well as the similarities with the well-known methotrexate neurotoxicity. Owing to the same mode of action of both drugs by inhibition of the enzyme dihydrofolate reductase, this case is highly suggestive of the pathogenetic role of methylation pathway blockade on myelin synthesis resulting in delayed demyelination. This complication could be avoided by a concurrent folinic acid supplementation.
Source: Journal of the Neurological Sciences - October 24, 2013 Category: Neurology Authors: Thomas de Broucker, Delphine Leclercq, Sergio Jarquin, Carole Henry Tags: Original Articles Source Type: research

Diagnostic and therapeutic aspects of Hashimoto's encephalopathy
Conclusions: We present a cohort of patients in whom CNS dysfunction was associated with elevated antithyroid antibodies and reversal of disease followed immunomodulatory therapies.
Source: Journal of the Neurological Sciences - June 7, 2013 Category: Neurology Authors: Inan Olmez, Harold Moses, Subramaniam Sriram, Howard Kirshner, Andre H. Lagrange, Siddharama Pawate Tags: Original Articles Source Type: research