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Nonlinear relationship between pulse pressure and risk of cognitive impairment: A 4-year community-based cohort study in Xi'an, China
It has been known that pulse pressure (PP) is a risk factor for cardiovascular disease and stroke, however, the relationship between PP and cognitive impairment is unclear.
Source: Journal of the Neurological Sciences - March 10, 2023 Category: Neurology Authors: Rong Zhou, Yanyu Wang, Ling Gao, Liangjun Dang, Suhang Shang, Ningwei Hu, Wei Peng, Yi Zhao, Shan Wei, Ye Yuan, Fan Gao, Jin Wang, Qiumin Qu Source Type: research

Covert COVID-19 complications: Continuing the use of evidence-based drugs to minimize potentially lethal indirect effects of the pandemic in stroke patients
Stroke and cardiovascular diseases are the world's biggest killers, globally accounting for over 15 million deaths each year (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). Since the Coronavirus Disease 2019 (COVID-19) outbreak in Wuhan, China and its rapid spread to other countries, as of April 272,020, there were about 3 million cases with over 190,000 deaths worldwide. However, actual situation might be even more dire, since such statistics likely do not fully display the entire impact of COVID-19, especially with regard to its influence on patients with a history of stroke who need to tak...
Source: Journal of the Neurological Sciences - May 5, 2020 Category: Neurology Authors: Meng Lee, Chi-Hsin Sally Chen, Bruce Ovbiagele Tags: Letter to the Editor Source Type: research

Predictors of malignant cerebral edema in cerebral artery infarction: A meta-analysis
Malignant cerebral edema (MCE) is a life-threatening complication of acute cerebral stroke. To date, the focus has been on symptomatic treatment, rather than on prevention. Therefore, to identify high-risk patients and explore potential therapeutic approaches, we investigated the possible predictors of MCE. Specifically, we performed a meta-analysis to identify the potential predictors of MCE in patients with acute cerebral infarction. We searched the MEDLINE, Embase, Cochrane, China National Knowledge Infrastructure, Wanfang Data, and VIP databases from their inception to July 2018 for cohort and case control studies on t...
Source: Journal of the Neurological Sciences - December 2, 2019 Category: Neurology Authors: Jinfeng Miao, Xiaoyan Song, Wenzhe Sun, Xiuli Qiu, Yan Lan, Zhou Zhu Tags: Review Article Source Type: research

Heteroplasmy and phenotype spectrum of the mitochondrial tRNALeu (UUR) gene m.3243A > G mutation in seven Han Chinese families
The m.3243A  > G mutation in the mitochondrial tRNALeu (UUR) gene is associated with a variety of phenotypic heterogeneity. The clinical spectrum and phenotypic-genotypic correlations in the Chinese patients are poorly understood. In the present study, we reported the clinical and genetic characterization, as w ell as haplogroups of seven Han Chinese families carrying the m.3243A > G mutation. Of the 39 matrilineal individuals, five suffered from mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), two had life-threatening mitochondrial myopathy (LTMM), and one patient had neuropathy,...
Source: Journal of the Neurological Sciences - November 5, 2019 Category: Neurology Authors: Gailing Liu, Xiya Shen, Yongan Sun, Qing Lv, Yuanyuan Li, Ailian Du Source Type: research

Factors associated with stigma in community-dwelling stroke survivors in China: A cross-sectional study
Although stigma is considered to be present in stroke patients, the factors that influence its level are ambiguous. The aim of this study was to investigate whether certain demographic, clinical, and psychosocial characteristics are related to higher levels of stigma among stroke patients in China.
Source: Journal of the Neurological Sciences - September 11, 2019 Category: Neurology Authors: CuiYu Deng, Qi Lu, Lili Yang, Rui Wu, Yi Liu, LiYa Li, Shixiang Cheng, Siqi Wei, Yulu Wang, Yaqi Huang, Li Fu, Yue Zhao Source Type: research

Response to letter of “hemoglobin level as a predictor of clinical outcome in patients with ischemic stroke” by Tomoyuki Kawada
We are grateful to Tomoyuki Kawada for the interest in our article —“Hemoglobin level and three-month clinical outcomes among ischemic stroke patients with elevated systolic blood pressure” [1]. It makes sense to involve peer scientists in the extensive discussions on our findings. The aim of our study was to investigate the association between hemoglobin and prognosis of ischemic stroke among patients from the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke).
Source: Journal of the Neurological Sciences - February 26, 2019 Category: Neurology Authors: Daoxia Guo, Yonghong Zhang Tags: Letter to the Editor Source Type: research

Effects of mechanical thrombectomy for acute stroke patients with etiology of large artery atherosclerosis
Atherosclerosis is more prevalent in Asian population. This distinct etiology of stroke might disadvantage Asian patients when applying.mechanical thrombectomy (MT). The purpose of this research was to evaluate the efficacy and safety of MT in a cohort of Chinese patients with acute ischemic stroke.due to large artery atherosclerosis (LAA).
Source: Journal of the Neurological Sciences - October 19, 2018 Category: Neurology Authors: Bo Sun, Zhonghua Shi, Jie Pu, Shiquan Yang, Huaiming Wang, Dong Yang, Yonggang Hao, Min Lin, Wei Ke, Wenhua Liu, Fuqiang Guo, Yongjie Bai, Shuai Zhang, Zibao Li, Shun Li, Meng Zuo, Gelin Xu, Wenjie Zi, Xinfeng Liu Source Type: research

Hyperglycemia predicts unfavorable outcomes in acute ischemic stroke patients treated with intravenous thrombolysis among a Chinese population: A prospective cohort study
In this study, we investigated whether an elevated admission serum glucose level in the 3-h time window of intravenous thrombolysis for acute ischemic stroke determined poor functional outcomes among Chinese population.
Source: Journal of the Neurological Sciences - March 16, 2018 Category: Neurology Authors: Sheng-Feng Lin, A-Ching Chao, Han-Hwa Hu, Ruey-Tay Lin, Chih-Hung Chen, Lung Chan, Huey-Juan Lin, Yu Sun, Yung-Yang Lin, Po-Lin Chen, Shinn-Kuang Lin, Ming-Hui Sun, Cheng-Yu Wei, Yu-Te Lin, Jiunn-Tay Lee, Chi-Huey Bai, Taiwan Thrombolytic Therapy for Acut Source Type: research

Characteristics of the ischemic stroke patients whose seizures occur at stroke presentation at a single institution in Eastern China
We compared clinical characteristics and outcomes of the early-onset seizure post-stroke patients who had seizures occurring at stroke presentation (SSP) with other patients without SSP at a single institution in Eastern China.
Source: Journal of the Neurological Sciences - February 4, 2018 Category: Neurology Authors: Jian-Hua Cheng, Zheng Zhang, Qiang Ye, Zu-sen Ye, Nian-ge Xia Source Type: research

Survival analysis of a cohort of Chinese patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) based on clinical features
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a common mitochondrial syndrome. The aim of this study was to conduct a survival analysis based on the clinical features of a Chinese MELAS patient cohort.
Source: Journal of the Neurological Sciences - December 28, 2017 Category: Neurology Authors: Zhe Zhang, Danhua Zhao, Xiao Zhang, Hui Xiong, Xinhua Bao, Yun Yuan, Zhaoxia Wang Source Type: research

Discrepant relationships between admission blood pressure and mortality in different stroke subtypes
The relationship between blood pressure(BP) and clinical outcome in patients with acute stroke is still controversial. The present study aimed to elucidate the impact of admission blood pressure on mortality in patients with acute stroke of different subtypes. Data were from ChinaQUEST (QUality Evaluation of Stroke Care and Treatment), a multicenter, prospective hospital registry study in 37 cities across China. A total of 6427 patients were admitted within 24h of onset and after following up for 12months, 5501 were included in the final analysis.
Source: Journal of the Neurological Sciences - September 22, 2017 Category: Neurology Authors: Yuanyuan Liu, Yide Yang, Haiqiang Jin, Chenghe Fan, Pu Lv, Wei Sun, Qing Peng, Mingming Zhao, David K. Jin, Jiguang Wang, Lawrence K.S. Wong, Craig S. Anderson, Lemin Zheng, Yining Huang, ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) Invest Source Type: research

Association of SAA gene polymorphism with ischemic stroke in northern Chinese Han population
Serum amyloid A protein (SAA) is known as an inflammatory factor and an apolipoprotein that can replace apolipoprotein A-I/II components as the major apolipoprotein of high-density lipoprotein (HDL), which is related to atherosclerosis. The present study is aimed to evaluate whether the SAA gene polymorphism is involved in ischemic stroke in northern Chinese Han population.
Source: Journal of the Neurological Sciences - July 9, 2017 Category: Neurology Authors: Jie Zhao, Xiangyu Piao, Yue Wu, Ping Xu, Zhiyi He Source Type: research