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Basilar artery curvature is associated with migraine with aura in the Northern Manhattan Study
We examined the relationship between basilar artery (BA) curvature and MA in a population-based cohort of stroke-free participants.
Source: Journal of the Neurological Sciences - November 26, 2021 Category: Neurology Authors: Dixon Yang, Cen Zhang, Setareh S. Omran, Brett Cucchiara, Tatjana Rundek, Clinton B. Wright, Ralph L. Sacco, Mitchell S.V. Elkind, Jose Gutierrez Source Type: research

Genetic and NONGENETIC factors associated with CADASIL: A retrospective cohort study
Objective: To explore the role of cardiovascular risk factors and the different NOTCH-3 mutations to explain the variability observed in the clinical presentation of CADASIL.Methods: This was a retrospective cohort study of 331 individuals, 90 were carriers of four mutations in the NOTCH3 gene. These four mutations are the ones identified in our region from the genetic evaluation of probands. Cox proportional hazards models were fitted to estimate the effect of genetic and cardiovascular factors on the onset of migraine, first stroke, and dementia.
Source: Journal of the Neurological Sciences - October 12, 2020 Category: Neurology Authors: Carolina Ospina, Joseph F. Arboleda-Velasquez, Daniel Camilo Aguirre-Acevedo, Yesica Zuluaga-Casta ño, Lina Velilla, Gloria P. Garcia, Yakeel T. Quiroz, M.D. Francisco Lopera Source Type: research

Cerebral vascular reactivity and the migraine-stroke relationship: A narrative review
Migraine, and especially migraine with aura, is associated with an increased risk of stroke and vascular events; however, the reasons for this association are unclear. Several studies evaluated cerebral autoregulation and vasomotor reactivity in patients with migraine compared with non-migraineurs, with conflicting results. Our narrative review aimed at summarizing their results to find the most reliable evidence in the field. Studies which used visual stimuli to evoke vascular responses consistently showed an increased vascular reactivity in migraineurs compared with non-migraineurs, while studies which used systemic stim...
Source: Journal of the Neurological Sciences - May 4, 2020 Category: Neurology Authors: Raffaele Ornello, Ilaria Frattale, Valeria Caponnetto, Francesca Pistoia, Simona Sacco Tags: Review Article Source Type: research

Pathogenicity of the variant m.13376  T  >  C in ND5 remains unproven
With interest we read the article by Sasaki et al. about a 14  years old Japanese female with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome being attributed to the variant m.13376 T > C in ND5 [1]. The variant had been transmitted via the maternal line as the mother carried the same variant with high heteroplasmy rate but manifested differentially with only short stature and headache [1] The study has a number of shortcomings.
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research

Pathogenicity of the variant m.13376  T  >  C in ND5 remains unproven
With interest we read the article by Sasaki et al. about a 14  years old Japanese female with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome being attributed to the variant m.13376 T > C in ND5 [1]. The variant had been transmitted via the maternal line as the mother carried the same variant with high heteroplasmy rate but manifested differentially with only short stature and headache [1] The study has a number of shortcomings.
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research

Is there a timing for sensitivity to acute cerebral ischemia in migraine patients?
Migraine may be a factor of increased cerebral sensitivity to ischemia. Previous studies were conducted within 6 to 72 after stroke onset. We aimed to determine if an accelerated infarct growth exists in migraine patients within the first 4.5  h.
Source: Journal of the Neurological Sciences - October 12, 2019 Category: Neurology Authors: Isabelle Francillard, Lou Grangeon, Agathe Cornillot, Estelle Houivet, Ozlem Ozkul-Wermester, Aude Triquenot-Bagan, Benjamin Hebant, David Maltete, Emmanuel Gerardin, Evelyne Guegan-Massardier Source Type: research

Gadolinium enhancement in perforating arteries in a patient with varicella zoster virus vasculopathy: A case report
A 35-year-old man was admitted to our hospital because of right hemiparesis. His initial National Institutes of Health Stroke Scale score was 8. He had a 1-week history of fever and headache that had occurred approximately 1  month prior to admission. Diffusion-weighted imaging on admission showed hyperintensities in the left putamen and corona radiata (Supplementary Fig. 1). There were no atherosclerotic changes or findings suggesting intracranial arterial dissection or carotid artery disease on magnetic resonance (M R) angiography.
Source: Journal of the Neurological Sciences - June 13, 2019 Category: Neurology Authors: Yoshitaka Yamaguchi, Kozue Morioka, Hikaru Nagasawa, Manabu Wada Tags: Letter to the Editor Source Type: research

Mitochondrial metabolic stroke: Phenotype and genetics of stroke-like episodes
Stroke-like episodes (SLEs) are the hallmark of mitochondrial encephalopathy with lactic acidosis and stroke-like episode (MELAS) syndrome but rarely occur also in other specific or nonspecific mitochondrial disorders. Pathophysiologically, SLLs are most likely due to a regional disruption of the blood-brain barrier triggered by the underlying metabolic defect, epileptic activity, drugs, or other factors. SLEs manifest clinically with a plethora of cerebral manifestations, which not only include features typically seen in ischemic stroke, but also headache, epilepsy, ataxia, visual impairment, vomiting, and psychiatric abnormalities.
Source: Journal of the Neurological Sciences - March 22, 2019 Category: Neurology Authors: Josef Finsterer Tags: Review Article Source Type: research

Cerebrovascular reactivity in subjects with migraine: Age paradox?
Migraine, and especially migraine with aura, is a recognized risk factor for stroke [1]; however, the mechanisms underlying the association between migraine and stroke are unclear. Notably, previous studies found that the contribution of migraine to the risk of stroke is more significant in younger women compared with the older ones [2,3] and in women with active migraine compared with those with past history of migraine [4], suggesting the presence of a migraine-specific factor increasing the risk of stroke.
Source: Journal of the Neurological Sciences - January 25, 2019 Category: Neurology Authors: Raffaele Ornello, Cindy Tiseo, Francesca Pistoia, Simona Sacco Tags: Editorial Source Type: research

Paradoxical association between age and cerebrovascular reactivity in migraine: A cross-sectional study
Previous studies reported an increased risk of ischemic stroke in younger migraineurs. We aimed to investigate the association between age and cerebrovascular reactivity (CVR) to vasodilatory stimuli in cerebral arteries in patients with migraine and normal controls.
Source: Journal of the Neurological Sciences - January 24, 2019 Category: Neurology Authors: Mi Ji Lee, Soohyun Cho, Sook-Young Woo, Chin-Sang Chung Source Type: research

SMART syndrome with cerebral angiographic abnormalities - A case report
Black et al. first used the terminology ‘stroke-like migraine attacks after radiation therapy (SMART) syndrome’ and proposed diagnostic criteria in 2006 [1]. Proposed diagnostic criteria are remote history of cerebral radiotherapy, prolonged but reversible signs and symptoms referable to a unilateral cortical region and nearly reversi ble diffuse gyral and leptomeningeal enhancement within the symptomatic area [2]. However, these criteria do not include angiographic features. To the best of our knowledge, our case is the first report to show vascular change by means of digital subtraction angiography.
Source: Journal of the Neurological Sciences - August 22, 2017 Category: Neurology Authors: Ji-Hyung Park, Moo-seok Park, Gyeong-Moon Kim Tags: Letter to the Editor Source Type: research

Spinal cord and cranial Bing-Neel Syndrome complicated by cerebral ischemia: A case report
Waldenström's macroglobulinemia (WM) is a B-cell malignancy characterized by lymphoplasmacytic lymphoma (LPL) within the bone marrow and an IgM monoclonal gammopathy in the blood. Symptoms may include weakness or fatigue, anorexia and weight loss, bleeding from the gums and nose, headache, blurred vision, peripheral neuropathy, and even stroke from hyperviscosity. The direct infiltration of the central nervous system (CNS), either as a diffuse leptomeningeal form or tumoral form is an exceedingly rare complication of WM, recognized as Bing-Neel Syndrome (BNS) [1].
Source: Journal of the Neurological Sciences - April 24, 2016 Category: Neurology Authors: Alejandro Vargas, Karan S. Dixit, John G. Quigley, Fernando D. Testai Tags: Letter to the Editor Source Type: research

Cerebral hemorrhages in CADASIL: Report of four cases and a brief review
Conclusions: Hemorrhagic stroke can occur in CADASIL similarly to sporadic cerebral small vessel diseases; this finding expands the phenotype of the disease. A diagnosis of CADASIL should probably be considered also in patients with ICH. These data bear potential implications in terms of need of better control of risk factors, particularly hypertension, and raise relevant questions about the use of antiplatelets as prevention measures in CADASIL patients.
Source: Journal of the Neurological Sciences - May 2, 2013 Category: Neurology Authors: Valentina Rinnoci, Serena Nannucci, Raffaella Valenti, Ida Donnini, Silvia Bianchi, Francesca Pescini, Maria Teresa Dotti, Antonio Federico, Domenico Inzitari, Leonardo Pantoni Tags: Original Articles Source Type: research

Use of DWI-only MR protocol for screening stroke mimics
Abstract: Purpose: Patients presenting with focal neurological symptoms may suffer from stroke or stroke mimics. Diffusion weighted MRI (DWI) is highly sensitive for identifying acute ischemia. Therefore, we aimed to explore whether a DWI-only protocol would help differentiate stroke from stroke mimics.Methods: We identified all patients with possible but not definite stroke that underwent DWI-only MRI between 6/2010 and 8/2011. Patients with a positive DWI lesion were compared to those with negative DWI findings on demographics, risk factor profile, final discharge diagnoses, and outcome.Results: A total of 124 patients w...
Source: Journal of the Neurological Sciences - March 15, 2013 Category: Neurology Authors: Roni Eichel, Tamir Ben Hur, John M. Gomori, Jose E. Cohen, Ronen R. Leker Tags: Original Articles Source Type: research