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Source: Journal of Stroke and Cerebrovascular Diseases
Drug: Insulin
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Total 19 results found since Jan 2013.
Associations of Serum C-Peptide Level with Body Fat Distribution and Ever Stroke in Nondiabetic Subjects
Conclusion: The serum C-peptide level is strongly associated with the ever stroke in nondiabetic subjects and significantly associated with total and regional body fat distribution.
Source: Journal of Stroke and Cerebrovascular Diseases - October 17, 2013 Category: Neurology Authors: Ying Li, Lu Meng, Yue Li, Yasuto Sato Tags: Original Articles Source Type: research
Changes in Serum Growth Factors in Stroke Rehabilitation Patients and Their Relation to Hemiparesis Improvement
Predicting recovery from hemiparesis after stroke is important for rehabilitation. A few recent studies reported that the levels of some growth factors shortly after stroke were positively correlated with the clinical outcomes during the chronic phase. The aim of this study was to examine the relationships between the serum levels of growth factors (vascular endothelial growth factor [VEGF], insulin-like growth factor-I [IGF-I], and hepatocyte growth factor [HGF]) and improvement in hemiparesis in stroke patients who received rehabilitation in a postacute rehabilitation hospital. Subjects were 32 stroke patients (cerebral ...
Source: Journal of Stroke and Cerebrovascular Diseases - April 25, 2014 Category: Neurology Authors: Hideto Okazaki, Hidehiko Beppu, Kenmei Mizutani, Sayaka Okamoto, Shigeru Sonoda Tags: Original Articles Source Type: research
Post-stroke cognitive impairment and the risk of stroke recurrence and death in patients with insulin resistance
Post-stroke cognitive impairment (PSCI) is associated with etiology, severity, and functional outcome of stroke. The risks of recurrent stroke and death in patients with PSCI and insulin resistance (IR) is unknown. The goal of this study was to determine whether global and domain-specific cognitive impairment after stroke in patients with IR was associated with recurrent stroke and death.
Source: Journal of Stroke and Cerebrovascular Diseases - August 27, 2022 Category: Neurology Authors: Kat Schmidt, Melinda C. Power, Adam Ciarleglio, Zurab Nadareishvili, IRIS Study Group Source Type: research
Decrease in Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-1 Ratio in the First Week of Stroke Is Related to Positive Outcomes
High insulin-like growth factor-1 (IGF-1), measured once during acute stroke, is associated with greater survival rates and lower stroke severity. However, information is lacking regarding how IGF-1 availability, determined by IGF-1's ratio to insulin-like growth factor binding protein-3 (IGFBP-3), relates to recovery and how the response of IGF-1 during the first week of stroke relates to outcomes. The purpose of this study was to determine the following: (1) the relationship between percent change in IGF-1 and IGF-1 ratio during the first week of stroke and stroke outcomes; and (2) the difference in percent change in IGF...
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2016 Category: Neurology Authors: Anna E. Mattlage, Michael A. Rippee, Janice Sandt, Sandra A. Billinger Source Type: research
Resistive Training Improves Insulin Sensitivity after Stroke
This study determined the effects of unilateral resistive training (RT) of both the paretic and nonparetic legs on insulin sensitivity in stroke survivors.Methods: We studied 10 participants (mean age 65 ± 2 years; mean body mass index 27 ± 4 kg/m2) with hemiparetic gait after remote (>6 months) ischemic stroke. All subjects underwent 1-repetition maximum (1-RM) strength testing, 9 had an oral glucose tolerance test (OGTT), and 7 completed a 2-hour hyperglycemic clamp (with glucose elevation targeted at 98 mg/dL above baseline fasting level) before and after 12 weeks (3×/week) of progressive, high repetition, high-i...
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2013 Category: Neurology Authors: Frederick M. Ivey, Alice S. Ryan Tags: Original Articles Source Type: research
Longitudinal Relationship Between Intramuscular Fat in the Quadriceps and Gait Independence in Convalescent Stroke Patients
In stroke patients, secondary changes in the skeletal muscles, including decreased muscle mass and increased intramuscular fat, have been examined after stroke onset.1 These changes are greater on the paretic side than on the non-paretic side.2,3 In chronic stroke survivors, these secondary changes in skeletal muscles are associated with decreased muscle strength,4 gait independence,5 and aerobic exercise capacity.6 Furthermore, Ryan et al.2 have reported that increased intramuscular fat in stroke patients is associated with decreased insulin sensitivity.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2020 Category: Neurology Authors: Taisei Ishimoto, Yusuke Taniguchi, Naoki Akazawa Source Type: research
Microembolic Signals is Associated With Insulin Resistance Among Acute Ischemic Stroke Patients
This study aims to investigate the clinical correlation between intracranial MES and IR in AIS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Xuyou Zhou, Dongmei Zhang, Yong Zhou, Fang Wang, Xiangyang Zhu Source Type: research
Effect of Low-Intensity Ergometer Aerobic Training on Glucose Tolerance in Severely Impaired Nondiabetic Stroke Patients
Objective: To investigate whether low-intensity ergometer aerobic training has beneficial effect on glucose tolerance in nondiabetic patients with severely impaired stroke.Methods: Fifty-four severely impaired stroke survivors were recruited and randomly assigned to the experimental group and control group. They have no diabetes history with fasting plasma glucose less than 7 mmol/L. Both groups participated in a 6-week rehabilitation training program with low-intensity ergometer aerobic training added only in the experimental group 3 times per week. Primary outcome variables were fasting glucose, fasting insulin, 2-hour ...
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2013 Category: Neurology Authors: Zun Wang, Lei Wang, Hongjuan Fan, Xiao Lu, Tong Wang Tags: Original Articles Source Type: research
Neurovascular Protection by Telmisartan via Reducing Neuroinflammation in Stroke-Resistant Spontaneously Hypertensive Rat Brain after Ischemic Stroke
We examined the effects of telmisartan on neurovascular unit (N-acetylglucosamine oligomer [NAGO], collagen IV, and glial fibrillary acidic protein [GFAP]) and neuroinflammation (matrix metalloproteinase-9 [MMP-9] and inflammasome) in brain of stroke-resistant spontaneously hypertensive rat (SHR-SR). At 12 weeks of age, SHR-SR received transient middle cerebral artery occlusion (tMCAO) for 90 minutes and were divided into the following 3 groups, that is, vehicle group, low-dose telmisartan group (.3 mg/kg/d), and high-dose telmisartan group (3 mg/kg/d, postoral).
Source: Journal of Stroke and Cerebrovascular Diseases - December 19, 2014 Category: Neurology Authors: Syoichiro Kono, Tomoko Kurata, Kota Sato, Yoshio Omote, Nozomi Hishikawa, Toru Yamashita, Kentaro Deguchi, Koji Abe Source Type: research
Long-term Amelioration of Telmisartan on Metabolic Syndrome-related Molecules in Stroke-resistant Spontaneously Hypertensive Rat after Transient Middle Cerebral Artery Occlusion
We examined the effects of telmisartan on metabolic syndrome-related molecules such as insulin receptor (IR), peroxisome proliferator-activated receptor gamma (PPAR-γ), and angiotensin 2 type 1 receptor (AT1R) in stroke-resistant spontaneously hypertensive rat (SHR-SR) after transient middle cerebral artery occlusion (tMCAO), by administering telmisartan at either 0 (vehicle), .3 mg/kg/day (low dose), or 3 mg/kg/day (high dose), postoperatively, from 3 months of age and performed immunohistologic analysis at 6, 12, and 18 months of age.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2014 Category: Neurology Authors: Kentaro Deguchi, Tomoko Kurata, Yusuke Fukui, Wentao Liu, Zhai Yun, Yoshio Omote, Kota Sato, Syoichiro Kono, Nozomi Hishikawa, Toru Yamashita, Koji Abe Source Type: research
A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack
We sought to develop an instrument to screen for insulin resistance in nondiabetic patients with recent ischemic stroke or transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2016 Category: Neurology Authors: Jin Xu, Catherine M. Viscoli, Gary A. Ford, Mark Gorman, Walter N. Kernan, IRIS Trial Investigators Source Type: research
Resistive Training and Molecular Regulators of Vascular-Metabolic Risk in Chronic Stroke
Peroxisome proliferator-activated receptor (PPAR)- γ coactivator (PGC-1α) gene and Sirtuin-1 (SIRT-1) respond to physiological stimuli and regulate insulin resistance. Inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and the soluble forms of intracellular adhesion molecule (sICAM-1) and vas cular CAM-1 (sVCAM-1) are associated with increased risk of diabetes and coronary heart disease. Resistive training (RT) reduces hyperinsulinemia and improves insulin action in chronic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2016 Category: Neurology Authors: Alice S. Ryan, Guoyan Li, Charlene Hafer-Macko, Frederick M. Ivey Source Type: research
Insulin Resistance is Significantly Related with Worse Clinical Outcomes in Non-Diabetic Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
to investigate the relationship between insulin resistance (IR) and clinical outcomes in non-diabetic ischemic stroke patients treated with intravenous thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2020 Category: Neurology Authors: Xiaoli Yang, Chen Li, Jing Li, Duanlu Hou, Yufan Luo, Shufan Zhang, Zhi Jin, Liwei Shen, Ping Zhong, Danhong Wu Source Type: research
