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Dynamic Changes in Brain Iron Metabolism in Neonatal Rats after Hypoxia-Ischemia
The pathogenesis of hypoxic-ischemic white matter injury (WMI) in premature infants is still unclear, and the imbalance of cerebral iron metabolism may play an important role. Our study set out to investigate the changes in iron distribution, iron content and malondialdehyde (MDA) in disparate brain regions (parietal cortex, corpus callosum, hippocampus) within 84 days after hypoxia-ischemia (HI) in neonatal rats and to clarify the role of iron metabolism in WMI.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2022 Category: Neurology Authors: Ding-Wang Hu, Geng Zhang, Ling Lin, Xuan-Jing Yu, Feng Wang, Qing Lin Source Type: research

Therapeutic Effects of Iron Chelation in Atorvastatin-Induced Intracranial Hemorrhage of Zebrafish Larvae
Intracranial hemorrhage (ICH) acutely and severely damages brain function.1,2 The prognosis of ICH is poor due to the drastic and rapid progression of its pathology, and the lack of effective treatments presents a significant unmet clinical need. Therefore, novel therapeutic agents for ICH have the potential to significantly improve clinical outcomes. The collagenase-induced rodent ICH model is the most commonly used experimental ICH model.3 However, detailed live imaging of hematoma development in rodent models is inherently limited, as rodents are opaque.
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2020 Category: Neurology Authors: Shinsuke Nakamura, Yuichi Saito, Takumi Gouda, Takahiko Imai, Masamitsu Shimazawa, Yuhei Nishimura, Hideaki Hara Source Type: research

Brainstem iron overload and injury in a rat model of brainstem hemorrhage
Brainstem hemorrhage (BSH) is the most devastating subtype of intracerebral hemorrhage (ICH) with the highest mortality ranging from 56 % to 61.2 %. However, there is no effective medical or surgical therapy to improve its outcomes in clinic to date due to lack of understanding of its injury mechanisms. Herein, we explored the brainstem iron overload and injury in a rat model of BSH.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Xi Guo, Lu Ma, Hao Li, Xin Qi, Yang Wei, Zhongxin Duan, Jiake Xu, Chengwei Wang, Chao You, Meng Tian Source Type: research

Cerebral Venous Thrombosis after Red Blood Cell Transfusion for the Treatment of Iron Deficiency Anemia
A 57-year-old male presented with generalized seizure who received red blood cell (RBC) transfusion for the treatment of iron deficiency anemia (IDA). Neuroradiological findings revealed cerebral venous thrombosis (CVT) on the left frontal vein. He received anticoagulants, anticonvulsants, and iron supplements. He discharged without any neurological deficit. It should be noted that RBC transfusion might increase the risk of CVT in patients with IDA.
Source: Journal of Stroke and Cerebrovascular Diseases - August 20, 2019 Category: Neurology Authors: Taku Inada, Nobutake Sadamasa, Ryota Motoie, Norikazu Yamana, Waro Taki Tags: Case Report Source Type: research

Edaravone Reduces Iron-Mediated Hydrocephalus and Behavioral Disorder in Rat by Activating the Nrf2/HO-1 Pathway
Our previous studies have demonstrated that hemorrhage-derived iron has a key role in causing brain injury after intraventricular hemorrhage (IVH). Based on this finding, we hypothesized that edaravone, a free-radical scavenger, has the potential to alleviate hydrocephalus and neurological deficits post-IVH by suppressing iron-induced oxidative stress. Thus, this study aimed to investigate the efficacy of edaravone for rats with FeCl3 injection, as well as to explore the related molecular mechanism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 8, 2018 Category: Neurology Authors: Jianbo Zhang, Xia Shi, Zhi Chen, Junjun Geng, Yuelong Wang, Hua Feng, Gang Zhu, Qianwei Chen Source Type: research

Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients
The purpose of this study is to assess the validity and feasibility of macrophage imaging using an ultrasmall superparamagnetic iron oxide nanoparticle, ferumoxytol, in the cerebral aneurysmal wall in an animal model and in humans.
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2017 Category: Neurology Authors: Tomohiro Aoki, Makoto Saito, Hirokazu Koseki, Keiichi Tsuji, Atsushi Tsuji, Kiyoshi Murata, Hidetoshi Kasuya, Akio Morita, Shuh Narumiya, Kazuhiko Nozaki, MR Macrophage Imaging Study Investigators Source Type: research