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Parietomotor connectivity in the contralesional hemisphere after stroke: a paired-pulse TMS study
Stroke is the main cause of acquired disability in adults. Upper limb paresis is one of the most frequent symptoms after stroke; the recovery of upper limb function is often problematic but constitutes a key factor in personal autonomy. Spatial neglect (defined as a failure to acknowledge or explore stimuli towards the contralesional side) (Heilman et al. 2000) is another challenging consequence of stroke, since it slows recovery and impairs activities of daily living (Di Monaco et al. 2011). In fact, spatial neglect is a frequent consequence of lesions in the right hemisphere - especially those affecting the inferior pari...
Source: Clinical Neurophysiology - February 27, 2017 Category: Neuroscience Authors: Etienne Allart, Arnaud Delval, Alexandre Caux-Dedeystere, Julien Labreuche, Romain Viard, Renaud Lopes, Herv é Devanne Source Type: research

P 165 Incidence, clinical characteristics and longterm course of headache in patients with stroke (DMKG multicenter study)
Post stroke headache is a symptom which is generally not further differentiated. According to previous European and American studies, it is a common phenomenon. Nevertheless, other symptoms of stroke, such as palsy or aphasia, are dominating clinical assessments. However, the symptom “headache” can be an essential part of the clinical picture as in subarachnoid bleeding or cerebral venous thrombosis and it is unclear which risk factors modulate the symptoms and the occurrence of headache in stroke.
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: S. Dietrich, A. D üring, D. Rothkirch, F. Filippopulos, O. Eren, T. Dresler, T. Buchwald, A. Straube, S. Zierz, G. Goßrau, T. Kraya Tags: Poster Source Type: research

P28. The functional role of the anterior intraparietal sulcus for recovery of hand function in chronic stroke patients – A combined fMRI-TMS study
After stroke, neuroimaging studies frequently show increased activation of contralesional regions such as the primary motor cortex (M1) and the anterior intraparietal sulcus (aIPS) during movements of the impaired hand (Rehme et al., 2012). There is evidence that these areas may adopt either supportive or disturbing implications for motor control, depending on multiple factors, such as age, stroke severity, and lesion location (Di Pino et al., 2014). Importantly, previous research has mainly focused on investigating this question in the contralesional M1, while other areas involved in motor control, such as the aIPS have o...
Source: Clinical Neurophysiology - July 10, 2018 Category: Neuroscience Authors: F. Lange, L. Hensel, C. Tscherpel, C. Grefkes Source Type: research

34. Modulation of cortical activity by botulinum toxin type a in patients with post-stroke arm spasticity
Conclusion: Study of 2 age-matched groups with mild and severe weakness demonstrated different effect of BoNT-lowered spasticity on motor system engagement. Group A during movement imagery at maximum BoNT effect manifested deactivation of visual and default mode system, perhaps a change from visual to kinesthetic imagery, with cerebellum participating. Group B during movement also manifested motor pattern normalization, especially reduced activation extent.Supported by IGA MZ CR NT13575.
Source: Clinical Neurophysiology - April 7, 2014 Category: Neuroscience Authors: P. Hluštík, T. Veverka, P. Hok, Z. Tüdös, P. Otruba, A. Krobot, P. Kaňovský Tags: Society Proceedings Source Type: research

Perception of lower extremity loading in stroke
We read with great interest the article entitled “Perception of lower extremity loads in stroke survivors” by Chu et al. (2014). There is a dearth of studies regarding perception of loading in stroke population. We applaud the authors for the contemporary thoughts on the method of measuring lower extremity dynamic load perception. We take this opportunity to share few scientific facts related to the scope of this article.
Source: Clinical Neurophysiology - October 25, 2014 Category: Neuroscience Authors: Senthil N.S. Kumar, Leonard H Joseph, Ahmad Pharmy Jalil Tags: Letter to the Editor Source Type: research

P109. Parietofrontal motor pathways and their association with motor function after stroke
A stroke results in widespread alterations of motor-related brain activity and interregional interactions in the sensorimotor network. Numerous studies have investigated the functional relevance of the primary motor cortices (M1) and predominantly frontal and prefrontal secondary motor areas. Only few studies focused on the functional role of the ventral premotor cortex (PMv) and the posterior parietal cortex (PPC) after stroke. Corticocortical interactions between M1, PMv and posterior parietal motor areas, such as the anterior (aIPS) and caudal intraparietal sulcus (cIPS) are relevant for skilled voluntary hand function.
Source: Clinical Neurophysiology - July 5, 2015 Category: Neuroscience Authors: P. Koch, R. Schulz, M. Zimerman, M. Wessel, M. Bönstrup, G. Thomalla, B. Cheng, C. Gerloff, F.C. Hummel Source Type: research

P108. The effect of task effort on recovery-related brain activity following motor stroke assessed with FMRI and EEG
Spontaneous recovery of motor deficits after stroke evolve at a rather unpredictable fashion regarding the time and extend of skill reacquisition (Langhorne et al., Lancet, 2011). Previous longitudinal studies investigating brain activity during recovery from hand motor deficits point to an early overactivation of the motor network with a decrease back to near normal patterns later after stroke (Rehme et al., Neuroimage, 2012). Since patients regain force and skill during recovery, changes in neural activation over time could be explained by a decreased relative task effort over time.
Source: Clinical Neurophysiology - July 5, 2015 Category: Neuroscience Authors: M. Bönstrup, R. Schulz, B. Cheng, J. Feldheim, G. Thomalla, F. Hummel, C. Gerloff Source Type: research

ID 290 – Differences in sleep microstate curves among healthy sleepers and patients after stroke
Sleep deprivation, whether from disorder or lifestyle, poses a significant risk in daytime performance. Ischemic stroke resulting in cerebral lesions is a well-known acute disorder that leaves affected patients strongly vulnerable to sleep disturbances that often lead to the above-mentioned impairments. The aim of this study is to identify objective sleep patterns being potential sources of disturbed sleep in stroke patients.
Source: Clinical Neurophysiology - February 11, 2016 Category: Neuroscience Authors: Z. Rošt‘áková, R. Rosipal Source Type: research

ID 430 – The value of the P300 event related potential in the ischemic stroke
So far, only little is known about the impact of stroke on Event Related Potentials. The aim of this prospective study was to follow-up P300 latencies and choice reaction time in stroke patients and evaluate their changes over a prospective 1-year follow-up period.
Source: Clinical Neurophysiology - February 11, 2016 Category: Neuroscience Authors: M. Dejanovic, V. Ivetic, V. Nestorovic, Z. Milanovic, M. Miric Source Type: research

Reply to “The usefulness of diffusion tensor tractography for estimating the state of corticobulbar tract in stroke patients”
Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging technique used to demonstrate the structural integrity of white matter tracts. DTI has a unique advantage in visualizing the neural fiber tracts in the proximity of cerebral infarction by use of constructing three-dimensional images of white matter fiber tracts (Mori and van Zijl, 2002). A diffusion tensor tractography (DTT) study by Dr Jang investigated the injury of the corticobulbar tract (CBT) in stroke patients with dysarthria, and suggested that the evaluation of the CBT using DTT provides important information in stroke patients with bulbar sym...
Source: Clinical Neurophysiology - May 3, 2016 Category: Neuroscience Authors: Juan Du, Fang Yang, Xinfeng Liu Tags: Letter to the Editor Source Type: research

The usefulness of diffusion tensor tractography for estimating the state of corticobulbar tract in stroke patients
The development of diffusion tensor tractography (DTT), which is derived from diffusion tensor imaging data, has enabled the reconstruction and estimation of the corticobulbar tract (CBT) in the live human brain (Mori et al., 1999). As a result, injury of the CBT following stroke could be estimated three dimensionally using DTT (Kwon et al., 2016). Several studies using DTT have reported on the detailed anatomical location of the CBT in the subcortical white matter, and this knowledge has enabled clinicians to presume injury of the CBT in stroke patients without DTT for the CBT (Pan et al., 2012; Yim et al., 2013).
Source: Clinical Neurophysiology - May 3, 2016 Category: Neuroscience Authors: Sung Ho Jang, So Min Shin Tags: Letter to the Editor Source Type: research

EP 5. Decrement of the effect of neuromuscular electrical stimulation over time in chronic stroke patients
Neuromuscular electrical stimulation (NMES) has been applied as one rehabilitative treatment option in stroke patients (Quandt and Hummel, 2014) and a meta-analysis recently showed its positive effects on motor recovery (Stein et al., 2015). One major challenge in stroke patients, especially severely impaired, is the opening of the hand due to extensor weakness accompanied by flexor spasticity. Here, NMES could provide assistance and substitute lost function. Studies in healthy controls have shown, however, that the rapid onset of muscle fatigue is a critical limitation for practical use.
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: F. Quandt, J. Feldheim, J.C. Loitz, D. Wolff, M. Rohm, R. Rupp, W.H. Krautschneider, F.C. Hummel Source Type: research

EPV 19. Dissociable regions for recognition and execution of conceptual and spatio-temporal action characteristics in acute stroke patients
The ability to recognize and respond to actions performed by others is fundamental for a wide range of activities involving social interactions. However, despite an enormous number of functional imaging studies, a precise delineation of the brain regions crucial for distinct aspects of action recognition has remained elusive. Moreover, the degree of overlap between regions involved in active action performance is controversial.To elucidate these issues, 98 acute stroke patients (68 male, age meanSD, 6513 years) were examined in the acute period after stroke (meanSD 4.42 days after symptom onset).
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: M. Martin, A. Dressing, L. Beume, T. Bormann, I. Mader, M. Rijntjes, C.P. Kaller, C. Weiller Source Type: research

Need for updating safety recommendations on repetitive transcranial magnetic stimulation in stroke patients
A paper entitled “Inhibition versus facilitation of contralesional motor cortices in stroke: Deriving a model to tailor brain stimulation” was published by Sankarasubramanian et al. in Clinical Neurophysiology in March 2017 (Sankarasubramanian et al., 2017). That article reported the results of a study that aime d at investigating whether facilitation of contralesional dorsal premotor cortex by repetitive transcranial magnetic stimulation (rTMS) permitted to improve upper-limb function in severely affected post-stroke patients.
Source: Clinical Neurophysiology - June 2, 2017 Category: Neuroscience Authors: Bertrand Glize, Dominique Guehl, M élanie Cogné Tags: Letter to the Editor Source Type: research

O204 Simultaneous bi-hemispheric repetitive transcranial magnetic stimulation for upper limb motor recovery in chronic stroke: A double blind placebo controlled study
repetitive transcranial magnetic stimulation (rTMS) is a promising intervention for the treatment of post-stroke motor deficits. Since the crucial role of non-primary motor cortices and contralesional brain areas is emerging for motor recovery in chronic stroke; we assessed safety and efficacy of bilateral rTMS over the motor areas associated to physical training (PT) on upper extremity (UE) motor function.
Source: Clinical Neurophysiology - August 17, 2017 Category: Neuroscience Authors: Raffaella Chieffo, Giuseppe Scopelliti, Mario Fichera, Giovanni Di Maggio, Roberto Santangelo, Simone Guerrieri, Elise Houdayer, Abraham Zangen, Giancarlo Comi, Letizia Leocani Source Type: research

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