• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Generating artificial sensations with spinal cord stimulation in primates and rodents
For patients who have lost sensory function due to a neurological injury such as spinal cord injury (SCI), stroke, or amputation, spinal cord stimulation (SCS) may provide a mechanism for restoring somatic sensations via an intuitive, non-visual pathway. Inspired by this vision, here we trained rhesus monkeys and rats to detect and discriminate patterns of epidural SCS. Thereafter, we constructed psychometric curves describing the relationship between different SCS parameters and the animal's ability to detect SCS and/or changes in its characteristics.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 17, 2021 Category: Neurology Authors: Amol P. Yadav, Shuangyan Li, Max O. Krucoff, Mikhail A. Lebedev, Muhammad M. Abd-El-Barr, Miguel A.L. Nicolelis Source Type: research

Deep brain stimulation of midbrain locomotor circuits in the freely moving pig
Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been studied as a therapeutic target in rodent models of stroke, parkinsonism, and spinal cord injury. Clinical DBS trials have targeted the closely related pedunculopontine nucleus in patients with Parkinson ’s disease as a therapy for gait dysfunction, with mixed reported outcomes. Recent studies suggest that optimizing the MLR target could improve its effectiveness.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 27, 2021 Category: Neurology Authors: Stephano J. Chang, Andrea J. Santamaria, Francisco J. Sanchez, Luz M. Villamil, Pedro Pinheiro Saraiva, Francisco Benavides, Yohjans Nunez-Gomez, Juan P. Solano, Ioan Opris, James D. Guest, Brian R. Noga Source Type: research

Use of human invasive SEEG and non-invasive EEG recordingsin vivo towards tDCS dose individualization
Transcranial direct current stimulation (tDCS) is a type of non-invasive neuromodulatory rehabilitative therapy that has been the focus of many recent studies in a variety of disease conditions, e.g., stroke, spinal cord injury (SCI), depression, etc. However, one hurdle for success is the variability in behavioral outcomes across different subjects. One reason for such inter-individual variability is differences in tDCS-generated electric fields (EF) inside the brain of each subject and thus the resulting tDCS-modulated neural activity.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: P. Chhatbar, J. Halford, W. Vandergrift, Y. Zhang, W. Feng, M. George, S. Kautz Source Type: research