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Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow-derived mesenchymal stem cells (SB623): a phase 1/2a study.
CONCLUSIONSIn this completed 2-year phase 1/2a study, implantation of SB623 cells in patients with stable chronic stroke was safe and was accompanied by improvements in clinical outcomes.Clinical trial registration no.: NCT01287936 (clinicaltrials.gov). PMID: 30497166 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 1, 2018 Category: Neurosurgery Tags: J Neurosurg Source Type: research

Short- and long-term outcomes of moyamoya patients post-revascularization
CONCLUSIONS: In this large, single-center surgical series, most of the adult and pediatric patients had direct revascularization, with a 4.2% per-bypass-procedure (6.8% per patient) 30-day major stroke risk and a 0.6% per-patient-year long-term stroke risk. The authors identified various risk factors that are highly correlated with postoperative morbidity (age, mMRI score, and HDR score) and are involved in ongoing work to develop the predictive modeling for future patient selection and treatment.PMID:36272120 | DOI:10.3171/2022.8.JNS22336
Source: Journal of Neurosurgery - October 22, 2022 Category: Neurosurgery Authors: Mario Teo Kumar Abhinav Teresa E Bell-Stephens Venkatesh S Madhugiri Eric S Sussman Tej Deepak Azad Rohaid Ali Rogelio Esparza Michael Zhang Gary K Steinberg Source Type: research

Timing and nature of in-house postoperative events following uncomplicated elective endovascular aneurysm treatment.
Conclusions The large majority of significant postprocedural events after uncomplicated endovascular aneurysm intervention occur within the first 4 hours; these events become less frequent with increasing time. Transfer to a floor bed after 4-12 hours for further observation is reasonable to consider in some patients. PMID: 25170666 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 29, 2014 Category: Neurosurgery Authors: Arias EJ, Patel B, Cross DT, Moran CJ, Dacey RG, Zipfel GJ, Derdeyn CP Tags: J Neurosurg Source Type: research

Pure arterial malformations.
CONCLUSIONS Pure arterial malformations are rare lesions that are often detected incidentally and probably have a benign natural history. These lesions can affect any of the intracranial arteries and are likely best managed conservatively. PMID: 28960150 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - September 29, 2017 Category: Neurosurgery Authors: Brinjikji W, Cloft HJ, Flemming KD, Comelli S, Lanzino G Tags: J Neurosurg Source Type: research

Lumbar drain trial outcomes of normal pressure hydrocephalus: a single-center experience of 254 patients.
CONCLUSIONSThe LD trial is generally safe and well tolerated. The best predictors of passing the LD trial include a negative history of stroke and having disproportionate subarachnoid spaces. PMID: 30611143 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 4, 2019 Category: Neurosurgery Authors: El Ahmadieh TY, Wu EM, Kafka B, Caruso JP, Neeley OJ, Plitt A, Aoun SG, Olson DM, Ruchinskas RA, Cullum CM, Barnett S, Welch BG, Batjer HH, White JA Tags: J Neurosurg Source Type: research

Strategy and effect of repeat bypass surgery for anterior/posterior circulation in refractory moyamoya disease.
CONCLUSIONSRepeat bypass surgery was feasible and effective to reduce further incidence of headache attack, transient ischemic attack, and ischemic/hemorrhagic stroke in moyamoya disease patients. Through precise radiological analysis, surgical procedures should be planned to yield maximal therapeutic effects. PMID: 31151103 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - May 30, 2019 Category: Neurosurgery Authors: Uchino H, Kashiwazaki D, Akioka N, Koh M, Kuwayama N, Houkin K, Kuroda S Tags: J Neurosurg Source Type: research

Cerebrovascular complications and granuloma formation after wrapping or coating of intracranial aneurysms with cotton gauze and human fibrin adhesives: results from a single-center patient series over a 5-year period.
Conclusions These data should add to the awareness of significant cerebrovascular complications following wrapping or coating of IAs with cotton gauze and human fibrin adhesives and indicate that major ischemic strokes need to be included in the risk/benefit considerations during decision making for such treatment strategies. Patients who receive IA wrapping should be monitored and followed up closely for arterial narrowing and granuloma formation. PMID: 23930856 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 9, 2013 Category: Neurosurgery Authors: Beitzke M, Leber KA, Deutschmann H, Gattringer T, Poltrum B, Fazekas F Tags: J Neurosurg Source Type: research

Dissecting pseudoaneurysms: predictors of symptom occurrence, enlargement, clinical outcome, and treatment.
CONCLUSIONS Dissecting pseudoaneurysms have a benign course and most will not cause symptoms or enlarge on follow-up. Medical treatment can be a sufficient, initial treatment for dissecting pseudoaneurysms. PMID: 26824374 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 29, 2016 Category: Neurosurgery Authors: Daou B, Hammer C, Chalouhi N, Starke RM, Jabbour P, Rosenwasser RH, Tjoumakaris S Tags: J Neurosurg Source Type: research

The demography of idiopathic normal pressure hydrocephalus: data on 3000 consecutive, surgically treated patients and a systematic review of the literature
CONCLUSIONS: Most iNPH patients undergo surgery in their 70s. Those aged < 60 years show slightly different symptomatology and probably present with a specific disease entity, indicating that the lower age limit for iNPH should be 60 years. iNPH patients have severe impairment preceded by a long diagnostic delay. Even though the included study designs differed, the systematic review showed that the disorder has a very low treatment incidence. The importance of diagnosing and treating iNPH is further emphasized by the fact that iNPH may account for a considerable part of all cases of dementia.PMID:35395629 | DOI:10.3171/2022.2.JNS212063
Source: Journal of Neurosurgery - April 8, 2022 Category: Neurosurgery Authors: Nina Sundstr öm Fredrik Lundin Lisa Arvidsson Mats Tullberg Carsten Wikkels ø Source Type: research

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