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Emergency decompressive surgery in patients with transtentorial brain herniation and pupillary abnormalities: the importance of improved pupillary response after osmotherapy and surgery
CONCLUSIONS: With aggressive medical and surgical management, patients with transtentorial brain herniation, including those with bilaterally fixed and dilated pupils, may have considerable rates of survival and functional recovery. Young age, less midline shift, and improved pupillary response following osmotic therapy or decompressive surgery are favorable prognosticators.PMID:37548576 | DOI:10.3171/2023.5.JNS23163
Source: Journal of Neurosurgery - August 7, 2023 Category: Neurosurgery Authors: Daniel W Griepp Aaron Miller Sahar Sorek Komal Naeem Stephanie Moawad David Klein Joseph A DeMattia Ralph Rahme Source Type: research

Optimizing maximum resection of glioblastoma: Raman spectroscopy versus 5-aminolevulinic acid
CONCLUSIONS: According to the study data, RS is capable of detecting tumor-infiltrated brain with higher sensitivity but lower specificity than the current standard of 5-ALA. With further technological and workflow advancements, RS in combination with protoporphyrin IX fluorescence may contribute to pathology-tailored glioma resection in the future.PMID:36681953 | DOI:10.3171/2022.11.JNS22693
Source: Journal of Neurosurgery - January 22, 2023 Category: Neurosurgery Authors: Johannes Herta Anna Cho Thomas Roetzer-Pejrimovsky Romana H öftberger Wolfgang Marik Gernot Kronreif Tanja Peilnsteiner Karl R össler Stefan Wolfsberger Source Type: research

The impact of high functional connectivity network hub resection on language task performance in adult low- and high-grade glioma.
CONCLUSIONS: Imaginary coherence measures of functional connectivity using MEG are able to identify HFC network sites within and around low- and high-grade gliomas. Removal of IES-negative HFC sites results in early transient postoperative decline in AN and SYN, which resolved by 3 months in all patients without stroke or early tumor progression. Measures of functional connectivity may therefore be a useful means of counseling patients about postoperative risk and assist with preoperative surgical planning. PMID: 32244221 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - April 2, 2020 Category: Neurosurgery Authors: Lee AT, Faltermeier C, Morshed RA, Young JS, Kakaizada S, Valdivia C, Findlay AM, Tarapore PE, Nagarajan SS, Hervey-Jumper SL, Berger MS Tags: J Neurosurg Source Type: research

BIO alleviates inflammation through inhibition of GSK-3 β in a rat model of intracerebral hemorrhage.
CONCLUSIONS: BIO posttreatment inhibited microglia activation, prevented inflammation and hippocampal cell death, and ameliorated functional and morphological outcomes in a rat ICH model through inactivation of GSK-3β. PMID: 31226691 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - June 20, 2019 Category: Neurosurgery Authors: Zhao S, Liu Z, Yu Z, Wu X, Li R, Tang X Tags: J Neurosurg Source Type: research

MicroRNA-195 protection against focal cerebral ischemia by targeting CX3CR1.
CONCLUSIONSTaken together, these findings suggest that miR-195 promotes neuronal cell survival against chronic cerebral ischemic damage by inhibiting CX3CR1-mediated neuroinflammation. This indicates that miR-195 may represent a novel target that regulates neuroinflammation and brain injury, thus offering a new treatment strategy for cerebral ischemic disorders. PMID: 30497184 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 1, 2018 Category: Neurosurgery Tags: J Neurosurg Source Type: research

Operative and consultative proportions of neurosurgical disease worldwide: estimation from the surgeon perspective.
CONCLUSIONS With a high level of confidence and strong concordance, neurosurgeons estimated that the vast majority of patients with central nervous system tumors, hydrocephalus, or neural tube defects mandate neurosurgical involvement. A significant proportion of other common neurological diseases, such as traumatic brain and spinal injury, vascular anomalies, and degenerative spine disease, demand the attention of a neurosurgeon-whether via operative intervention or expert counsel. These estimates facilitate measurement of the expected annual volume of neurosurgical disease globally. PMID: 29749918 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - May 11, 2018 Category: Neurosurgery Authors: Dewan MC, Rattani A, Baticulon RE, Faruque S, Johnson WD, Dempsey RJ, Haglund MM, Alkire BC, Park KB, Warf BC, Shrime MG Tags: J Neurosurg Source Type: research

Global neurosurgery: the current capacity and deficit in the provision of essential neurosurgical care. Executive Summary of the Global Neurosurgery Initiative at the Program in Global Surgery and Social Change.
CONCLUSIONS Each year, more than 5 million individuals suffering from treatable neurosurgical conditions will never undergo therapeutic surgical intervention. Populations in Africa and Southeast Asia, where the proportion of neurosurgeons to neurosurgical disease is critically low, are especially at risk. Increasing access to essential neurosurgical care in low- and middle-income countries via neurosurgical workforce expansion as part of surgical system strengthening is necessary to prevent severe disability and death for millions with neurological disease. PMID: 29701548 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - April 27, 2018 Category: Neurosurgery Authors: Dewan MC, Rattani A, Fieggen G, Arraez MA, Servadei F, Boop FA, Johnson WD, Warf BC, Park KB Tags: J Neurosurg Source Type: research

Upregulation of miR-216a exerts neuroprotective effects against ischemic injury through negatively regulating JAK2/STAT3-involved apoptosis and inflammatory pathways.
CONCLUSIONS These findings suggest that upregulation of miR-216a, which targets JAK2, could induce neuroprotection against ischemic injury in vitro and in vivo, which provides a potential therapeutic target for ischemic stroke. PMID: 29521586 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - March 9, 2018 Category: Neurosurgery Authors: Tian YS, Zhong D, Liu QQ, Zhao XL, Sun HX, Jin J, Wang HN, Li GZ Tags: J Neurosurg Source Type: research

Magnetic resonance susceptibility weighted imaging in neurosurgery: current applications and future perspectives.
Abstract Susceptibility weighted imaging (SWI) is a relatively new imaging technique. Its high sensitivity to hemorrhagic components and ability to depict microvasculature by means of susceptibility effects within the veins allow for the accurate detection, grading, and monitoring of brain tumors. This imaging modality can also detect changes in blood flow to monitor stroke recovery and reveal specific subtypes of vascular malformations. In addition, small punctate lesions can be demonstrated with SWI, suggesting diffuse axonal injury, and the location of these lesions can help predict neurological outcome in pati...
Source: Journal of Neurosurgery - July 24, 2015 Category: Neurosurgery Authors: Di Ieva A, Lam T, Alcaide-Leon P, Bharatha A, Montanera W, Cusimano MD Tags: J Neurosurg Source Type: research

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