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Source: Stroke
Drug: Activase

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Total 49 results found since Jan 2013.

Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke Basic Sciences
Conclusions— Our data demonstrate that DMT is an early phenomenon initiated before recanalization. We further show that alteplase-dependent maintenance of downstream perfusion during MCAO improves acute ischemic stroke outcome through a fibrinogen-dependent platelet aggregation reduction. Our results indicate that early targeting of DMT represents a therapeutic strategy to improve the benefit of large artery recanalization in acute ischemic stroke.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Desilles, J.-P., Loyau, S., Syvannarath, V., Gonzalez-Valcarcel, J., Cantier, M., Louedec, L., Lapergue, B., Amarenco, P., Ajzenberg, N., Jandrot-Perrus, M., Michel, J.-B., Ho-Tin-Noe, B., Mazighi, M. Tags: Fibrinolysis, Fibrinogen/fibrin, Acute Cerebral Infarction, Brain Circulation and Metabolism, Thrombolysis Basic Sciences Source Type: research

Low-Versus Standard-Dose Alteplase for Ischemic Strokes Within 4.5 Hours: A Comparative Effectiveness and Safety Study Clinical Sciences
Conclusions— The low-dose alteplase strategy was comparable to the standard-dose treatment in terms of the effectiveness and safety.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Kim, B. J., Han, M.-K., Park, T. H., Park, S.-S., Lee, K. B., Lee, B.-C., Yu, K.-H., Oh, M. S., Cha, J. K., Kim, D.-H., Lee, J., Lee, S. J., Ko, Y., Park, J.-M., Kang, K., Cho, Y.-J., Hong, K.-S., Kim, J.-T., Choi, J. C., Kim, D.-E., Shin, D.-I., Kim, W.- Tags: Thrombolysis Clinical Sciences Source Type: research

Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke Clinical Sciences
Conclusions— In women with acute ischemic stroke treated with alteplase, the administration of UA reduced infarct growth in selected patients and was better than placebo to reach excellent outcome. Clinical Trial Registration— URL: https://clinicaltrials.gov. Unique identifier: NCT00860366.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Llull, L., Laredo, C., Renu, A., Perez, B., Vila, E., Obach, V., Urra, X., Planas, A., Amaro, S., Chamorro, A. Tags: Cerebrovascular disease/stroke, Acute Cerebral Infarction, Emergency treatment of Stroke, Neuroprotectors, Oxidant stress Clinical Sciences Source Type: research

Effect of Intravenous Recombinant Tissue-Type Plasminogen Activator in Patients With Mild Stroke in the Third International Stroke Trial-3: Post Hoc Analysis Brief Reports
Conclusions— This post hoc analysis in a highly selected sample of IST-3 supports the rationale of A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS) trial—a randomized, phase IIIb study to evaluate IV r-tPA in mild ischemic stroke.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Khatri, P., Tayama, D., Cohen, G., Lindley, R. I., Wardlaw, J. M., Yeatts, S. D., Broderick, J. P., Sandercock, P., on behalf of the PRISMS and IST-3 Collaborative Groups Tags: Thrombolysis Brief Reports Source Type: research

Twenty-Year History of the Evolution of Stroke Thrombolysis With Intravenous Alteplase to Reduce Long-Term Disability Topical Reviews
Source: Stroke - July 27, 2015 Category: Neurology Authors: Campbell, B. C. V., Meretoja, A., Donnan, G. A., Davis, S. M. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Thrombolysis Topical Reviews Source Type: research

Acute Reperfusion Therapy and Stroke Care in Asia After Successful Endovascular Trials Understanding and Applying the Endovascular Trials
The current status of and prospects for acute stroke care in Asia in the situation where both intravenous thrombolysis and endovascular therapies have been recognized as established strategies for acute stroke are reviewed. Of 15 million people annually having stroke worldwide, 9 million are Asians. The burdens of both ischemic and hemorrhagic strokes are severe in Asia. The unique features of stroke in Asia include susceptibility to intracranial atherosclerosis, high prevalence of intracerebral hemorrhage, effects of dietary and lifestyle habits, and several disorders with genetic causes. These features affect acute strok...
Source: Stroke - May 22, 2015 Category: Neurology Authors: Toyoda, K., Koga, M., Hayakawa, M., Yamagami, H. Tags: Emergency treatment of Stroke, Anticoagulants, Thrombolysis, Angioplasty and Stenting Understanding and Applying the Endovascular Trials Source Type: research

Reperfusion of Very Low Cerebral Blood Volume Lesion Predicts Parenchymal Hematoma After Endovascular Therapy Clinical Sciences
Conclusions— These results suggest that VLCBV can be used for risk stratification of patients scheduled to undergo endovascular therapy in trials and routine clinical practice.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Mishra, N. K., Christensen, S., Wouters, A., Campbell, B. C. V., Straka, M., Mlynash, M., Kemp, S., Cereda, C. W., Bammer, R., Marks, M. P., Albers, G. W., Lansberg, M. G., for the DEFUSE 2 Investigators Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging, Intracerebral Hemorrhage, Angioplasty and Stenting Clinical Sciences Source Type: research

Alteplase for Acute Ischemic Stroke: Outcomes by Clinically Important Subgroups in the Third International Stroke Trial Clinical Sciences
Conclusions— Among the types of patient in the Third International Stroke Trial, this secondary analysis did not identify any subgroups for whom treatment should be avoided. Given the limitations of the analysis, we found no clear evidence to avoid treatment in patients with prior ischemic stroke, diabetes mellitus, or hypertension. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN25765518. http://www.controlled-trials.com/ISRCTN25765518.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Lindley, R. I., Wardlaw, J. M., Whiteley, W. N., Cohen, G., Blackwell, L., Murray, G. D., Sandercock, P. A. G., on behalf of the IST-3 Collaborative Group, Trial Steering Committee, Baigent, Chadwick, Tyrrell, Lowe, Dennis, Innes, Goodare, CT and MR readi Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Tenecteplase-Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke With Proven Occlusion Clinical Sciences
Conclusions— Administration of TNK–tissue-type plasminogen activator in minor stroke with intracranial occlusion is both feasible and safe. A larger randomized controlled trial is needed to prove that this treatment is efficacious. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01654445.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Coutts, S. B., Dubuc, V., Mandzia, J., Kenney, C., Demchuk, A. M., Smith, E. E., Subramaniam, S., Goyal, M., Patil, S., Menon, B. K., Barber, P. A., Dowlatshahi, D., Field, T., Asdaghi, N., Camden, M.-C., Hill, M. D., for the TEMPO-1 Investigators Tags: Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

Effect of Alteplase Within 6 Hours of Acute Ischemic Stroke on All-Cause Mortality (Third International Stroke Trial) Clinical Sciences
Conclusions— These exploratory analyses of the third International Stroke Trial (IST-3) trial support improving acute stroke patients’ access to earlier alteplase treatment, treatment of patients with poor prognosis, and further randomized controlled trials in minor stroke to replicate these findings. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN25765518.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Whiteley, W. N., Thompson, D., Murray, G., Cohen, G., Lindley, R. I., Wardlaw, J., Sandercock, P., on behalf of the IST-3 Collaborative Group Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Baseline National Institutes of Health Stroke Scale-Adjusted Time Window for Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Clinical Sciences
Conclusions— The impact of time-to-treatment on favorable outcome varies widely depending on baseline stroke severity. The window for favorable outcome was ≤120 min for moderate strokes. However, time-to-treatment seemed unrelated to functional outcome in mild and severe stroke.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Muchada, M., Rubiera, M., Rodriguez-Luna, D., Pagola, J., Flores, A., Kallas, J., Sanjuan, E., Meler, P., Alvarez-Sabin, J., Ribo, M., Molina, C. A. Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Remote Ischemic Perconditioning as an Adjunct Therapy to Thrombolysis in Patients With Acute Ischemic Stroke: A Randomized Trial Clinical Sciences
Conclusions— Although the overall results were neutral, a tissue survival analysis suggests that prehospital rPerC may have immediate neuroprotective effects. Future clinical trials should take such immediate effects, and their duration, into account. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00975962.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Hougaard, K. D., Hjort, N., Zeidler, D., Sorensen, L., Norgaard, A., Hansen, T. M., von Weitzel-Mudersbach, P., Simonsen, C. Z., Damgaard, D., Gottrup, H., Svendsen, K., Rasmussen, P. V., Ribe, L. R., Mikkelsen, I. K., Nagenthiraja, K., Cho, T.-H., Reding Tags: Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Neuroprotectors, Thrombolysis Clinical Sciences Source Type: research

Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke: Results From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register Clinical Sciences
Conclusions— Frequency of thrombolytic treatment seems to follow the same circadian pattern of stroke incidence, whereas its correspondence to a weekly pattern is less clear. Time of treatment is an independent predictor of outcome.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Lorenzano, S., Ahmed, N., Tatlisumak, T., Gomis, M., Davalos, A., Mikulik, R., Sevcik, P., Ollikainen, J., Wahlgren, N., Toni, D., for the SITS Investigators Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke?: Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register Clinical Sciences
Conclusions— Data from Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register suggest that intravenous thrombolysis may modify the observed survival and recovery advantage for men expected in the natural course of an ischemic stroke, with a possible larger beneficial treatment effect in women when compared with men.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Lorenzano, S., Ahmed, N., Falcou, A., Mikulik, R., Tatlisumak, T., Roffe, C., Wahlgren, N., Toni, D., on behalf of the SITS Investigators Tags: Clinical Sciences Source Type: research

Review, Historical Context, and Clarifications of the NINDS rt-PA Stroke Trials Exclusion Criteria: Part 1: Rapidly Improving Stroke Symptoms Clinical Sciences
Conclusions— A structured framework and quantitative approach toward defining RISS emerged through expert opinion and consensus. The term, RISS, should be reserved for those who improve to a mild deficit, specifically one which is perceived to be nondisabling. This is recommended to guide decision making on intravenous tPA eligibility going forward, including the design of future studies. An additional study of patients with rapid improvement to nonmild deficits is not justified because these patients should be treated.
Source: Stroke - August 26, 2013 Category: Neurology Authors: The Re-examining Acute Eligibility for Thrombolysis (TREAT) Task Force:, Levine, S. R., Khatri, P., Broderick, J. P., Grotta, J. C., Kasner, S. E., Kim, D., Meyer, B. C., Panagos, P., Romano, J., Scott, P., NINDS rt-PA Stroke Trial Investigators* Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research