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Unequal Access to Treatment With Intravenous Alteplase for Women With Acute Ischemic Stroke Brief Reports
Conclusions— Fewer women present themselves within 4 hours from stroke onset than men and consequently less often receive thrombolytic treatment. This difference may be caused by the older age of women on average and consequently women more often living alone. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN20405426.
Source: Stroke - August 26, 2013 Category: Neurology Authors: de Ridder, I., Dirks, M., Niessen, L., Dippel, D., on behalf of the PRACTISE Investigators Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Thrombolysis Brief Reports Source Type: research

Results of Membrane-activated Chelator Stroke Intervention Randomized Trial of DP-b99 in Acute Ischemic Stroke Major Clinical Trials
Conclusions— Despite encouraging preclinical and phase II trial data, DP-b99 shows no evidence of efficacy in treating human ischemic stroke.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Lees, K. R., Bornstein, N., Diener, H.-C., Gorelick, P. B., Rosenberg, G., Shuaib, A., for the MACSI Investigators* Tags: Neuroprotectors Major Clinical Trials Source Type: research

Thrombolysis in Stroke Despite Contraindications or Warnings? Clinical Sciences
Conclusions— This comprehensive retrospective analysis of various contraindications and warnings provides reassurance about benefits and risks of intravenous alteplase treatment in common clinical situations.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Frank, B., Grotta, J. C., Alexandrov, A. V., Bluhmki, E., Lyden, P., Meretoja, A., Mishra, N. K., Shuaib, A., Wahlgren, N. G., Weimar, C., Lees, K. R., for the VISTA Collaborators Tags: Thrombolysis Clinical Sciences Source Type: research

Impact of Early Blood Pressure Variability on Stroke Outcomes After Thrombolysis: The SAMURAI rt-PA Registry Brief Reports
Conclusions— Early systolic BP variability was positively associated with symptomatic intracerebral hemorrhage and death after intravenous thrombolysis.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Endo, K., Kario, K., Koga, M., Nakagawara, J., Shiokawa, Y., Yamagami, H., Furui, E., Kimura, K., Hasegawa, Y., Okada, Y., Okuda, S., Namekawa, M., Miyagi, T., Osaki, M., Minematsu, K., Toyoda, K. Tags: Acute Cerebral Infarction, Thrombolysis Brief Reports Source Type: research

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